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Shanshan Hu, Xibo Pei, Lunliang Duan, Zhou Zhu, Yanhua Liu, Junyu Chen, Tao Chen, Ping Ji, Qianbing Wan, Jian Wang
Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.
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Hu, S., Pei, X., Duan, L., Zhu, Z., Liu, Y., Chen, J., Chen, T., Ji, P., Wan, Q., & Wang, J. (2021). A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery. Nature Communications, 12(1), 1689. https://doi.org/10.1038/s41467-021-21989-5
Hu, Shanshan, et al. "A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery." Nature Communications, vol. 12, no. 1, 2021, pp. 1689, https://doi.org/10.1038/s41467-021-21989-5.
Hu, Shanshan, Xibo Pei, Lunliang Duan, Zhou Zhu, Yanhua Liu, Junyu Chen, Tao Chen, Ping Ji, Qianbing Wan, and Jian Wang. "A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery." Nature Communications 12, no. 1 (2021): 1689. https://doi.org/10.1038/s41467-021-21989-5.
Hu S., Pei X., Duan L. [и др.] A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery // Nature Communications. — 2021. — Vol. 12, № 1. — P. 1689. — URL: https://doi.org/10.1038/s41467-021-21989-5
@article{hu2021musselinspired,
title = {{A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery}},
author = {Shanshan Hu and Xibo Pei and Lunliang Duan and Zhou Zhu and Yanhua Liu and Junyu Chen and Tao Chen and Ping Ji and Qianbing Wan and Jian Wang},
journal = {Nature Communications},
year = {2021},
volume = {12},
number = {1},
pages = {1689},
doi = {10.1038/s41467-021-21989-5},
url = {https://doi.org/10.1038/s41467-021-21989-5}
}TY - JOUR AU - Hu, Shanshan AU - Pei, Xibo AU - Duan, Lunliang AU - Zhu, Zhou AU - Liu, Yanhua AU - Chen, Junyu AU - Chen, Tao AU - Ji, Ping AU - Wan, Qianbing AU - Wang, Jian TI - A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery JO - Nature Communications VL - 12 IS - 1 SP - 1689 PY - 2021 DA - 2021/03/16 DO - 10.1038/s41467-021-21989-5 UR - https://doi.org/10.1038/s41467-021-21989-5 ER -
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