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Keman Cheng, Ruifang Zhao, Yao Li, Yingqiu Qi, Yazhou Wang, Yinlong Zhang, Hao Qin, Yuting Qin, Long Chen, Chen Li and 9 more
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed. Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are qualified as immunoadjuvants. Here, we describe a versatile OMV-based vaccine platform to elicit a specific anti-tumor immune response via specifically presenting antigens onto OMV surface. We first display tumor antigens on the OMVs surface by fusing with ClyA protein, and then simplify the antigen display process by employing a Plug-and-Display system comprising the tag/catcher protein pairs. OMVs decorated with different protein catchers can simultaneously display multiple, distinct tumor antigens to elicit a synergistic antitumour immune response. In addition, the bioengineered OMVs loaded with different tumor antigens can abrogate lung melanoma metastasis and inhibit subcutaneous colorectal cancer growth. The ability of the bioengineered OMV-based platform to rapidly and simultaneously display antigens may facilitate the development of these agents for personalized tumour vaccines.
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Cheng, K., Zhao, R., Li, Y., Qi, Y., Wang, Y., Zhang, Y., Qin, H., Qin, Y., Chen, L., Li, C., Liang, J., Li, Y., Xu, J., Han, X., Anderson, G. J., Shi, J., Ren, L., Zhao, X., & Nie, G. (2021). Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology. Nature Communications, 12(1), 2041. https://doi.org/10.1038/s41467-021-22308-8
Cheng, Keman, et al. "Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology." Nature Communications, vol. 12, no. 1, 2021, pp. 2041, https://doi.org/10.1038/s41467-021-22308-8.
Cheng, Keman, Ruifang Zhao, Yao Li, Yingqiu Qi, Yazhou Wang, Yinlong Zhang, Hao Qin, et al. "Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology." Nature Communications 12, no. 1 (2021): 2041. https://doi.org/10.1038/s41467-021-22308-8.
Cheng K., Zhao R., Li Y. [и др.] Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology // Nature Communications. — 2021. — Vol. 12, № 1. — P. 2041. — URL: https://doi.org/10.1038/s41467-021-22308-8
@article{cheng2021bioengineered,
title = {{Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology}},
author = {Keman Cheng and Ruifang Zhao and Yao Li and Yingqiu Qi and Yazhou Wang and Yinlong Zhang and Hao Qin and Yuting Qin and Long Chen and Chen Li and Jie Liang and Yujing Li and Jiaqi Xu and Xuexiang Han and Gregory Jon Anderson and Jian Shi and Lei Ren and Xiao Zhao and Guangjun Nie},
journal = {Nature Communications},
year = {2021},
volume = {12},
number = {1},
pages = {2041},
doi = {10.1038/s41467-021-22308-8},
url = {https://doi.org/10.1038/s41467-021-22308-8}
}TY - JOUR AU - Cheng, Keman AU - Zhao, Ruifang AU - Li, Yao AU - Qi, Yingqiu AU - Wang, Yazhou AU - Zhang, Yinlong AU - Qin, Hao AU - Qin, Yuting AU - Chen, Long AU - Li, Chen AU - Liang, Jie AU - Li, Yujing AU - Xu, Jiaqi AU - Han, Xuexiang AU - Anderson, Gregory Jon AU - Shi, Jian AU - Ren, Lei AU - Zhao, Xiao AU - Nie, Guangjun TI - Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology JO - Nature Communications VL - 12 IS - 1 SP - 2041 PY - 2021 DA - 2021/04/06 DO - 10.1038/s41467-021-22308-8 UR - https://doi.org/10.1038/s41467-021-22308-8 ER -
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