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Wei Qiao, Karen H.M. Wong, Jie Shen, Wenhao Wang, Jun Wu, Jinhua Li, Zhengjie Lin, Zetao Chen, Zetao Chen, Jukka Pekka Matinlinna and 9 more
Despite the widespread observations on the osteogenic effects of magnesium ion (Mg 2+ ), the diverse roles of Mg 2+ during bone healing have not been systematically dissected. Here, we reveal a previously unknown, biphasic mode of action of Mg 2+ in bone repair. During the early inflammation phase, Mg 2+ contributes to an upregulated expression of transient receptor potential cation channel member 7 (TRPM7), and a TRPM7-dependent influx of Mg 2+ in the monocyte-macrophage lineage, resulting in the cleavage and nuclear accumulation of TRPM7-cleaved kinase fragments (M7CKs). This then triggers the phosphorylation of Histone H3 at serine 10, in a TRPM7-dependent manner at the promoters of inflammatory cytokines, leading to the formation of a pro-osteogenic immune microenvironment. In the later remodeling phase, however, the continued exposure of Mg 2+ not only lead to the over-activation of NF-κB signaling in macrophages and increased number of osteoclastic-like cells but also decelerates bone maturation through the suppression of hydroxyapatite precipitation. Thus, the negative effects of Mg 2+ on osteogenesis can override the initial pro-osteogenic benefits of Mg 2+ . Taken together, this study establishes a paradigm shift in the understanding of the diverse and multifaceted roles of Mg 2+ in bone healing.
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Qiao, W., Wong, K. H., Shen, J., Wang, W., Wu, J., Li, J., Lin, Z., Chen, Z., Chen, Z., Matinlinna, J. P., Zheng, Y., Wu, S., Liu, X., Lai, K. P., Chen, Z., Chen, Z., Lam, Y. W., Cheung, K., & Yeung, K. (2021). TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration. Nature Communications, 12(1), 2885. https://doi.org/10.1038/s41467-021-23005-2
Qiao, Wei, et al. "TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration." Nature Communications, vol. 12, no. 1, 2021, pp. 2885, https://doi.org/10.1038/s41467-021-23005-2.
Qiao, Wei, Karen H.M. Wong, Jie Shen, Wenhao Wang, Jun Wu, Jinhua Li, Zhengjie Lin, et al. "TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration." Nature Communications 12, no. 1 (2021): 2885. https://doi.org/10.1038/s41467-021-23005-2.
Qiao W., Wong K. H., Shen J. [и др.] TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration // Nature Communications. — 2021. — Vol. 12, № 1. — P. 2885. — URL: https://doi.org/10.1038/s41467-021-23005-2
@article{qiao2021trpm,
title = {{TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration}},
author = {Wei Qiao and Karen H.M. Wong and Jie Shen and Wenhao Wang and Jun Wu and Jinhua Li and Zhengjie Lin and Zetao Chen and Zetao Chen and Jukka Pekka Matinlinna and Yufeng Zheng and Shuilin Wu and Xuanyong Liu and Keng Po Lai and Zhuofan Chen and Zhuofan Chen and Yun Wah Lam and Kmc Cheung and Kwk Yeung},
journal = {Nature Communications},
year = {2021},
volume = {12},
number = {1},
pages = {2885},
doi = {10.1038/s41467-021-23005-2},
url = {https://doi.org/10.1038/s41467-021-23005-2}
}TY - JOUR AU - Qiao, Wei AU - Wong, Karen H.M. AU - Shen, Jie AU - Wang, Wenhao AU - Wu, Jun AU - Li, Jinhua AU - Lin, Zhengjie AU - Chen, Zetao AU - Chen, Zetao AU - Matinlinna, Jukka Pekka AU - Zheng, Yufeng AU - Wu, Shuilin AU - Liu, Xuanyong AU - Lai, Keng Po AU - Chen, Zhuofan AU - Chen, Zhuofan AU - Lam, Yun Wah AU - Cheung, Kmc AU - Yeung, Kwk TI - TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration JO - Nature Communications VL - 12 IS - 1 SP - 2885 PY - 2021 DA - 2021/05/17 DO - 10.1038/s41467-021-23005-2 UR - https://doi.org/10.1038/s41467-021-23005-2 ER -
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