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Pengchao Zhao, Xianfeng Xia, Xiayi Xu, Kevin Kai Chung Leung, Aliza Rai, Yingrui Deng, Boguang Yang, Huasheng Lai, Xin Peng, Peng Shi and 3 more
A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable of prolonged retention in the gastrointestinal tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled coacervate demonstrates significant pH- and salt-independent structural stability and forms a physically adhesive coating on a large surface area of intestinal tract with an extended residence time of more than 2 days to mediate the sustained release of preloaded water-soluble small molecule drugs in vivo. The orally administered drug-laden nanoparticle-assembled coacervate significantly mitigates the symptoms of inflammatory bowel disease, restores the diversity of gut microbiota, reduces systemic drug exposure, and improves the therapeutic efficacy in a rat acute colitis model compared with the oral administration of the same amount of drug in solution form. We suggest that the nanoparticle-assembled coacervate provides a promising drug delivery platform for management and treatment of numerous gastrointestinal diseases where controlled drug release with extended residence time is desired.
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Zhao, P., Xia, X., Xu, X., Leung, K. K. C., Rai, A., Deng, Y., Yang, B., Lai, H., Peng, X., Shi, P., Zhang, H., Chiu, P. W. Y., & Bian, L. (2021). Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy. Nature Communications, 12(1), 7162. https://doi.org/10.1038/s41467-021-27463-6
Zhao, Pengchao, et al. "Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy." Nature Communications, vol. 12, no. 1, 2021, pp. 7162, https://doi.org/10.1038/s41467-021-27463-6.
Zhao, Pengchao, Xianfeng Xia, Xiayi Xu, Kevin Kai Chung Leung, Aliza Rai, Yingrui Deng, Boguang Yang, et al. "Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy." Nature Communications 12, no. 1 (2021): 7162. https://doi.org/10.1038/s41467-021-27463-6.
Zhao P., Xia X., Xu X. [и др.] Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy // Nature Communications. — 2021. — Vol. 12, № 1. — P. 7162. — URL: https://doi.org/10.1038/s41467-021-27463-6
@article{zhao2021nanoparticleassembled,
title = {{Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy}},
author = {Pengchao Zhao and Xianfeng Xia and Xiayi Xu and Kevin Kai Chung Leung and Aliza Rai and Yingrui Deng and Boguang Yang and Huasheng Lai and Xin Peng and Peng Shi and Honglu Zhang and Philip Wai Yan Chiu and Liming Bian},
journal = {Nature Communications},
year = {2021},
volume = {12},
number = {1},
pages = {7162},
doi = {10.1038/s41467-021-27463-6},
url = {https://doi.org/10.1038/s41467-021-27463-6}
}TY - JOUR AU - Zhao, Pengchao AU - Xia, Xianfeng AU - Xu, Xiayi AU - Leung, Kevin Kai Chung AU - Rai, Aliza AU - Deng, Yingrui AU - Yang, Boguang AU - Lai, Huasheng AU - Peng, Xin AU - Shi, Peng AU - Zhang, Honglu AU - Chiu, Philip Wai Yan AU - Bian, Liming TI - Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy JO - Nature Communications VL - 12 IS - 1 SP - 7162 PY - 2021 DA - 2021/12/09 DO - 10.1038/s41467-021-27463-6 UR - https://doi.org/10.1038/s41467-021-27463-6 ER -
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