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Zhenyan Zhang, Qi Zhang, Tingzhang Wang, Nuohan Xu, Tao Lu, Wenjie Hong, Josep Peñuelas, Michael Richard Gillings, Meixia Wang, Wenwen Gao, Haifeng Qian
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many genes can confer resistance, but evaluating the relative health risks of ARGs is complex. Factors such as the abundance, propensity for lateral transmission and ability of ARGs to be expressed in pathogens are all important. Here, an analysis at the metagenomic level from various habitats (6 types of habitats, 4572 samples) detects 2561 ARGs that collectively conferred resistance to 24 classes of antibiotics. We quantitatively evaluate the health risk to humans, defined as the risk that ARGs will confound the clinical treatment for pathogens, of these 2561 ARGs by integrating human accessibility, mobility, pathogenicity and clinical availability. Our results demonstrate that 23.78% of the ARGs pose a health risk, especially those which confer multidrug resistance. We also calculate the antibiotic resistance risks of all samples in four main habitats, and with machine learning, successfully map the antibiotic resistance threats in global marine habitats with over 75% accuracy. Our novel method for quantitatively surveilling the health risk of ARGs will help to manage one of the most important threats to human and animal health.
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Zhang, Z., Zhang, Q., Wang, T., Xu, N., Lu, T., Hong, W., Peñuelas, J., Gillings, M. R., Wang, M., Gao, W., & Qian, H. (2022). Assessment of global health risk of antibiotic resistance genes. Nature Communications, 13(1), 1553. https://doi.org/10.1038/s41467-022-29283-8
Zhang, Zhenyan, et al. "Assessment of global health risk of antibiotic resistance genes." Nature Communications, vol. 13, no. 1, 2022, pp. 1553, https://doi.org/10.1038/s41467-022-29283-8.
Zhang, Zhenyan, Qi Zhang, Tingzhang Wang, Nuohan Xu, Tao Lu, Wenjie Hong, Josep Peñuelas, et al. "Assessment of global health risk of antibiotic resistance genes." Nature Communications 13, no. 1 (2022): 1553. https://doi.org/10.1038/s41467-022-29283-8.
Zhang Z., Zhang Q., Wang T. [и др.] Assessment of global health risk of antibiotic resistance genes // Nature Communications. — 2022. — Vol. 13, № 1. — P. 1553. — URL: https://doi.org/10.1038/s41467-022-29283-8
@article{zhang2022assessment,
title = {{Assessment of global health risk of antibiotic resistance genes}},
author = {Zhenyan Zhang and Qi Zhang and Tingzhang Wang and Nuohan Xu and Tao Lu and Wenjie Hong and Josep Peñuelas and Michael Richard Gillings and Meixia Wang and Wenwen Gao and Haifeng Qian},
journal = {Nature Communications},
year = {2022},
volume = {13},
number = {1},
pages = {1553},
doi = {10.1038/s41467-022-29283-8},
url = {https://doi.org/10.1038/s41467-022-29283-8}
}TY - JOUR AU - Zhang, Zhenyan AU - Zhang, Qi AU - Wang, Tingzhang AU - Xu, Nuohan AU - Lu, Tao AU - Hong, Wenjie AU - Peñuelas, Josep AU - Gillings, Michael Richard AU - Wang, Meixia AU - Gao, Wenwen AU - Qian, Haifeng TI - Assessment of global health risk of antibiotic resistance genes JO - Nature Communications VL - 13 IS - 1 SP - 1553 PY - 2022 DA - 2022/03/23 DO - 10.1038/s41467-022-29283-8 UR - https://doi.org/10.1038/s41467-022-29283-8 ER -
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