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Jingjing Qi, Hongxiang Sun, Yao Zhang, Zhengting Wang, Zhenzhen Xun, Ziyi Li, Xinyu Ding, Rujuan Bao, Liwen Hong, Wenqing Jia and 11 more
Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables the discovery of potential therapeutic targets. Here, we profile 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidate the potential origin and regulation of tumor-enriched cell types in CRC. We demonstrate that the tumor-specific FAP + fibroblasts and SPP1 + macrophages were positively correlated in 14 independent CRC cohorts containing 2550 samples and validate their close localization by immuno-fluorescent staining and spatial transcriptomics. This interaction might be regulated by chemerin, TGF-β, and interleukin-1, which would stimulate the formation of immune-excluded desmoplasic structure and limit the T cell infiltration. Furthermore, we find patients with high FAP or SPP1 expression achieved less therapeutic benefit from an anti-PD-L1 therapy cohort. Our results provide a potential therapeutic strategy by disrupting FAP + fibroblasts and SPP1 + macrophages interaction to improve immunotherapy.
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Qi, J., Sun, H., Zhang, Y., Wang, Z., Xun, Z., Li, Z., Ding, X., Bao, R., Hong, L., Jia, W., Fang, F., Liu, H., Chen, L., Zhong, J., Zou, D., Liu, L., Han, L., Ginhoux, F., Liu, Y., … Su, B. (2022). Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nature Communications, 13(1), 1742. https://doi.org/10.1038/s41467-022-29366-6
Qi, Jingjing, et al. "Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer." Nature Communications, vol. 13, no. 1, 2022, pp. 1742, https://doi.org/10.1038/s41467-022-29366-6.
Qi, Jingjing, Hongxiang Sun, Yao Zhang, Zhengting Wang, Zhenzhen Xun, Ziyi Li, Xinyu Ding, et al. "Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer." Nature Communications 13, no. 1 (2022): 1742. https://doi.org/10.1038/s41467-022-29366-6.
Qi J., Sun H., Zhang Y. [и др.] Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer // Nature Communications. — 2022. — Vol. 13, № 1. — P. 1742. — URL: https://doi.org/10.1038/s41467-022-29366-6
@article{qi2022singlecell,
title = {{Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer}},
author = {Jingjing Qi and Hongxiang Sun and Yao Zhang and Zhengting Wang and Zhenzhen Xun and Ziyi Li and Xinyu Ding and Rujuan Bao and Liwen Hong and Wenqing Jia and Fei Fang and Hongzhi Liu and Lei Chen and Jie Zhong and Duowu Zou and Lianxin Liu and Leng Han and Florent Ginhoux and Yingbin Liu and Youqiong Ye and Bing Su},
journal = {Nature Communications},
year = {2022},
volume = {13},
number = {1},
pages = {1742},
doi = {10.1038/s41467-022-29366-6},
url = {https://doi.org/10.1038/s41467-022-29366-6}
}TY - JOUR AU - Qi, Jingjing AU - Sun, Hongxiang AU - Zhang, Yao AU - Wang, Zhengting AU - Xun, Zhenzhen AU - Li, Ziyi AU - Ding, Xinyu AU - Bao, Rujuan AU - Hong, Liwen AU - Jia, Wenqing AU - Fang, Fei AU - Liu, Hongzhi AU - Chen, Lei AU - Zhong, Jie AU - Zou, Duowu AU - Liu, Lianxin AU - Han, Leng AU - Ginhoux, Florent AU - Liu, Yingbin AU - Ye, Youqiong AU - Su, Bing TI - Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer JO - Nature Communications VL - 13 IS - 1 SP - 1742 PY - 2022 DA - 2022/04/01 DO - 10.1038/s41467-022-29366-6 UR - https://doi.org/10.1038/s41467-022-29366-6 ER -
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