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Atanas G. Atanasov, Sergey B. Zotchev, Verena Maria Dirsch, the International Natural Product Sciences Taskforce, İlkay Erdoğan Orhan, Maciej Banach, Judith Maria Rollinger, Davide Barreca, Wolfram Weckwerth, Rudolf Bauer and 64 more
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments - including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances - are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
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Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Taskforce, T. I. N. P. S., Orhan, İ. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V. N., Bonn, G. K., Braidy, N., Bučar, F., Cifuentes, A., D’Onofrio, G., … Supuran, C. T. (2021). Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery, 20(3), 200–216. https://doi.org/10.1038/s41573-020-00114-z
Atanasov, Atanas G., et al. "Natural products in drug discovery: advances and opportunities." Nature Reviews Drug Discovery, vol. 20, no. 3, 2021, pp. 200–216, https://doi.org/10.1038/s41573-020-00114-z.
Atanasov, Atanas G., Sergey B. Zotchev, Verena Maria Dirsch, the International Natural Product Sciences Taskforce, İlkay Erdoğan Orhan, Maciej Banach, Judith Maria Rollinger, et al. "Natural products in drug discovery: advances and opportunities." Nature Reviews Drug Discovery 20, no. 3 (2021): 200–216. https://doi.org/10.1038/s41573-020-00114-z.
Atanasov A. G., Zotchev S. B., Dirsch V. M. [и др.] Natural products in drug discovery: advances and opportunities // Nature Reviews Drug Discovery. — 2021. — Vol. 20, № 3. — P. 200–216. — URL: https://doi.org/10.1038/s41573-020-00114-z
@article{atanasov2021natural,
title = {{Natural products in drug discovery: advances and opportunities}},
author = {Atanas G. Atanasov and Sergey B. Zotchev and Verena Maria Dirsch and the International Natural Product Sciences Taskforce and İlkay Erdoğan Orhan and Maciej Banach and Judith Maria Rollinger and Davide Barreca and Wolfram Weckwerth and Rudolf Bauer and Edward A. Bayer and Muhammed Majeed and Anupam Bishayee and Valery N. Bochkov and Günther K. Bonn and Nady Braidy and Franz Bučar and Alejandro Cifuentes and Grazia D’Onofrio and Michael J. Bodkin and Marc F. Diederich and Albena T. Dinkova‐Kostova and Thomas Efferth and Khalid El Bairi and Nicolas Arkells and Tai-Ping Fan and Bernd L. Fiebich and Michael Freissmuth and Milen I. Georgiev and Simon Gibbons and Keith M. Godfrey and Christian W. Gruber and Jag P. Heer and Lukas Alfons Huber and Elena Ibáñez and Anake Kijjoa and Anna Karolina Kiss and Aiping Lü and Francisco Antonio Macías and Mark J.S. Miller and Andrei Mocan and Rolf Müller and Ferdinando Nicoletti and George L. Perry and Valeria Pittalà and Luca Rastrelli and Michael Ristow and Gian Luigi Russo and Ana T. Sanches-Silva and Daniela Schuster and Helen Sheridan and Krystyna Skalicka‐Woźniak and Alexios‐Léandros Skaltsounis and Eduardo Sobarzo‐Sánchez and David S. Bredt and Hermann Stuppner and Antoni Sureda and Nikolay T. Tzvetkov and Rosa Anna Vacca and Bharat Bhushan Aggarwal and Maurizio Battino and Francesca Giampieri and Michaël Wink and Jean‐Luc Wolfender and Jianbo Xiao and Andy Wai Kan Yeung and Gérard Lizard and Michael A. Popp and Michael Heinrich and Ioana Berindan‐Neagoe and Marc Stadler and Maria Daglia and Robert Verpoorte and Claudiu Trandafir Supuran},
journal = {Nature Reviews Drug Discovery},
year = {2021},
volume = {20},
number = {3},
pages = {200--216},
doi = {10.1038/s41573-020-00114-z},
url = {https://doi.org/10.1038/s41573-020-00114-z}
}TY - JOUR AU - Atanasov, Atanas G. AU - Zotchev, Sergey B. AU - Dirsch, Verena Maria AU - Taskforce, the International Natural Product Sciences AU - Orhan, İlkay Erdoğan AU - Banach, Maciej AU - Rollinger, Judith Maria AU - Barreca, Davide AU - Weckwerth, Wolfram AU - Bauer, Rudolf AU - Bayer, Edward A. AU - Majeed, Muhammed AU - Bishayee, Anupam AU - Bochkov, Valery N. AU - Bonn, Günther K. AU - Braidy, Nady AU - Bučar, Franz AU - Cifuentes, Alejandro AU - D’Onofrio, Grazia AU - Bodkin, Michael J. AU - Diederich, Marc F. AU - Dinkova‐Kostova, Albena T. AU - Efferth, Thomas AU - Bairi, Khalid El AU - Arkells, Nicolas AU - Fan, Tai-Ping AU - Fiebich, Bernd L. AU - Freissmuth, Michael AU - Georgiev, Milen I. AU - Gibbons, Simon AU - Godfrey, Keith M. AU - Gruber, Christian W. AU - Heer, Jag P. AU - Huber, Lukas Alfons AU - Ibáñez, Elena AU - Kijjoa, Anake AU - Kiss, Anna Karolina AU - Lü, Aiping AU - Macías, Francisco Antonio AU - Miller, Mark J.S. AU - Mocan, Andrei AU - Müller, Rolf AU - Nicoletti, Ferdinando AU - Perry, George L. AU - Pittalà, Valeria AU - Rastrelli, Luca AU - Ristow, Michael AU - Russo, Gian Luigi AU - Sanches-Silva, Ana T. AU - Schuster, Daniela AU - Sheridan, Helen AU - Skalicka‐Woźniak, Krystyna AU - Skaltsounis, Alexios‐Léandros AU - Sobarzo‐Sánchez, Eduardo AU - Bredt, David S. AU - Stuppner, Hermann AU - Sureda, Antoni AU - Tzvetkov, Nikolay T. AU - Vacca, Rosa Anna AU - Aggarwal, Bharat Bhushan AU - Battino, Maurizio AU - Giampieri, Francesca AU - Wink, Michaël AU - Wolfender, Jean‐Luc AU - Xiao, Jianbo AU - Yeung, Andy Wai Kan AU - Lizard, Gérard AU - Popp, Michael A. AU - Heinrich, Michael AU - Berindan‐Neagoe, Ioana AU - Stadler, Marc AU - Daglia, Maria AU - Verpoorte, Robert AU - Supuran, Claudiu Trandafir TI - Natural products in drug discovery: advances and opportunities JO - Nature Reviews Drug Discovery VL - 20 IS - 3 SP - 200 EP - 216 PY - 2021 DA - 2021/01/28 DO - 10.1038/s41573-020-00114-z UR - https://doi.org/10.1038/s41573-020-00114-z ER -
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