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François Pognan, Mario Beilmann, Harrie C. M. Boonen, Andreas Czich, Gordon J. Dear, Philip G. Hewitt, Tomas Joachim Mow, Teija Oinonen, Adrian B. Roth, Thomas Steger‐Hartmann and 4 more
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates. In recent years, however, technological advances have increasingly enabled researchers to gain insights into toxicity mechanisms, supporting greater understanding of species relevance and translatability to humans, prediction of safety events, mitigation of side effects and development of safety biomarkers. Consequently, investigative (or mechanistic) toxicology has been gaining momentum and is now a key capability in the pharmaceutical industry. Here, we provide an overview of the current status of the field using case studies and discuss the potential impact of ongoing technological developments, based on a survey of investigative toxicologists from 14 European-based medium-sized to large pharmaceutical companies. Investigative toxicology tools and strategies are used in pharmaceutical companies to reduce safety-related attrition in drug development. This Perspective article summarizes the key goals of investigative toxicology, highlights current approaches and discusses selected emerging technologies that have the potential to improve the current safety-testing paradigm.
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Pognan, F., Beilmann, M., Boonen, H. C. M., Czich, A., Dear, G. J., Hewitt, P. G., Mow, T. J., Oinonen, T., Roth, A. B., Steger‐Hartmann, T., Valentin, J., Goethem, F. V., Weaver, R. J., & Newham, P. (2023). The evolving role of investigative toxicology in the pharmaceutical industry. Nature Reviews Drug Discovery, 22(4), 317–335. https://doi.org/10.1038/s41573-022-00633-x
Pognan, François, et al. "The evolving role of investigative toxicology in the pharmaceutical industry." Nature Reviews Drug Discovery, vol. 22, no. 4, 2023, pp. 317–335, https://doi.org/10.1038/s41573-022-00633-x.
Pognan, François, Mario Beilmann, Harrie C. M. Boonen, Andreas Czich, Gordon J. Dear, Philip G. Hewitt, Tomas Joachim Mow, et al. "The evolving role of investigative toxicology in the pharmaceutical industry." Nature Reviews Drug Discovery 22, no. 4 (2023): 317–335. https://doi.org/10.1038/s41573-022-00633-x.
Pognan F., Beilmann M., Boonen H. C. M. [и др.] The evolving role of investigative toxicology in the pharmaceutical industry // Nature Reviews Drug Discovery. — 2023. — Vol. 22, № 4. — P. 317–335. — URL: https://doi.org/10.1038/s41573-022-00633-x
@article{pognan2023evolving,
title = {{The evolving role of investigative toxicology in the pharmaceutical industry}},
author = {François Pognan and Mario Beilmann and Harrie C. M. Boonen and Andreas Czich and Gordon J. Dear and Philip G. Hewitt and Tomas Joachim Mow and Teija Oinonen and Adrian B. Roth and Thomas Steger‐Hartmann and Jean‐Pierre Valentin and Freddy Van Goethem and Richard John Weaver and Peter Newham},
journal = {Nature Reviews Drug Discovery},
year = {2023},
volume = {22},
number = {4},
pages = {317--335},
doi = {10.1038/s41573-022-00633-x},
url = {https://doi.org/10.1038/s41573-022-00633-x}
}TY - JOUR AU - Pognan, François AU - Beilmann, Mario AU - Boonen, Harrie C. M. AU - Czich, Andreas AU - Dear, Gordon J. AU - Hewitt, Philip G. AU - Mow, Tomas Joachim AU - Oinonen, Teija AU - Roth, Adrian B. AU - Steger‐Hartmann, Thomas AU - Valentin, Jean‐Pierre AU - Goethem, Freddy Van AU - Weaver, Richard John AU - Newham, Peter TI - The evolving role of investigative toxicology in the pharmaceutical industry JO - Nature Reviews Drug Discovery VL - 22 IS - 4 SP - 317 EP - 335 PY - 2023 DA - 2023/02/13 DO - 10.1038/s41573-022-00633-x UR - https://doi.org/10.1038/s41573-022-00633-x ER -
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