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Baihao Zhang, Alexis Vogelzang, Michio Miyajima, Yuki Sugiura, Yibo Wu, Kenji Chamoto, Rei Nakano, Ryusuke Hatae, Rosemary J. Menzies, Kazuhiro Sonomura and 20 more
Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu 1–3 . Here we identify the metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages that secrete interleukin-10 and inhibit CD8 + T cell killer function. In mice, B cell deficiency or B cell-specific inactivation of the GABA-generating enzyme GAD67 enhances anti-tumour responses. Our study reveals that, in addition to cytokines and membrane proteins, small metabolites derived from B-lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses.
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Zhang, B., Vogelzang, A., Miyajima, M., Sugiura, Y., Wu, Y., Chamoto, K., Nakano, R., Hatae, R., Menzies, R. J., Sonomura, K., Hojo, N., Ogawa, T., Kobayashi, W., Tsutsui, Y., Yamamoto, S., Maruya, M., Narushima, S., Suzuki, K., Sugiya, H., … Fagarasan, S. (2021). B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity. Nature, 599(7885), 471–476. https://doi.org/10.1038/s41586-021-04082-1
Zhang, Baihao, et al. "B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity." Nature, vol. 599, no. 7885, 2021, pp. 471–476, https://doi.org/10.1038/s41586-021-04082-1.
Zhang, Baihao, Alexis Vogelzang, Michio Miyajima, Yuki Sugiura, Yibo Wu, Kenji Chamoto, Rei Nakano, et al. "B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity." Nature 599, no. 7885 (2021): 471–476. https://doi.org/10.1038/s41586-021-04082-1.
Zhang B., Vogelzang A., Miyajima M. [и др.] B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity // Nature. — 2021. — Vol. 599, № 7885. — P. 471–476. — URL: https://doi.org/10.1038/s41586-021-04082-1
@article{zhang2021cellderived,
title = {{B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity}},
author = {Baihao Zhang and Alexis Vogelzang and Michio Miyajima and Yuki Sugiura and Yibo Wu and Kenji Chamoto and Rei Nakano and Ryusuke Hatae and Rosemary J. Menzies and Kazuhiro Sonomura and Nozomi Hojo and Taisaku Ogawa and Wakana Kobayashi and Yumi Tsutsui and Sachiko Yamamoto and Mikako Maruya and Seiko Narushima and Keiichiro Suzuki and Hiroshi Sugiya and Kosaku Murakami and Motomu Hashimoto and Hideki Ueno and Takashi Kobayashi and Katsuhiro Ito and T Hirano and Katsuyuki Shiroguchi and Fumihiko Matsuda and Makoto Suematsu and Tasuku Honjo and Sidonia Fagarasan},
journal = {Nature},
year = {2021},
volume = {599},
number = {7885},
pages = {471--476},
doi = {10.1038/s41586-021-04082-1},
url = {https://doi.org/10.1038/s41586-021-04082-1}
}TY - JOUR AU - Zhang, Baihao AU - Vogelzang, Alexis AU - Miyajima, Michio AU - Sugiura, Yuki AU - Wu, Yibo AU - Chamoto, Kenji AU - Nakano, Rei AU - Hatae, Ryusuke AU - Menzies, Rosemary J. AU - Sonomura, Kazuhiro AU - Hojo, Nozomi AU - Ogawa, Taisaku AU - Kobayashi, Wakana AU - Tsutsui, Yumi AU - Yamamoto, Sachiko AU - Maruya, Mikako AU - Narushima, Seiko AU - Suzuki, Keiichiro AU - Sugiya, Hiroshi AU - Murakami, Kosaku AU - Hashimoto, Motomu AU - Ueno, Hideki AU - Kobayashi, Takashi AU - Ito, Katsuhiro AU - Hirano, T AU - Shiroguchi, Katsuyuki AU - Matsuda, Fumihiko AU - Suematsu, Makoto AU - Honjo, Tasuku AU - Fagarasan, Sidonia TI - B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity JO - Nature VL - 599 IS - 7885 SP - 471 EP - 476 PY - 2021 DA - 2021/11/03 DO - 10.1038/s41586-021-04082-1 UR - https://doi.org/10.1038/s41586-021-04082-1 ER -
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