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Niamh B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, Irene Molina-González, Katharine E. Askew, Stephen Mitchell and 18 more
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health 1 , it is unknown which macrophage populations are involved and which aspects they influence. Here we show that resident microglia are crucial for the maintenance of myelin health in adulthood in both mice and humans. We demonstrate that microglia are dispensable for developmental myelin ensheathment. However, they are required for subsequent regulation of myelin growth and associated cognitive function, and for preservation of myelin integrity by preventing its degeneration. We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte state with altered lipid metabolism. Moreover, this mechanism is regulated through disruption of the TGFβ1–TGFβR1 axis. Our findings highlight microglia as promising therapeutic targets for conditions in which myelin growth and integrity are dysregulated, such as in ageing and neurodegenerative disease 2,3 .
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McNamara, N. B., Munro, D. A. D., Bestard-Cuche, N., Uyeda, A., Bogie, J. F. J., Hoffmann, A., Holloway, R. K., Molina-González, I., Askew, K. E., Mitchell, S., Mungall, W., Dodds, M., Dittmayer, C., Moss, J., Rose, J. L., Szymkowiak, S., Amann, L., McColl, B. W., Prinz, M., … Miron, V. E. (2022). Microglia regulate central nervous system myelin growth and integrity. Nature, 613(7942), 120–129. https://doi.org/10.1038/s41586-022-05534-y
McNamara, Niamh B., et al. "Microglia regulate central nervous system myelin growth and integrity." Nature, vol. 613, no. 7942, 2022, pp. 120–129, https://doi.org/10.1038/s41586-022-05534-y.
McNamara, Niamh B., David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, et al. "Microglia regulate central nervous system myelin growth and integrity." Nature 613, no. 7942 (2022): 120–129. https://doi.org/10.1038/s41586-022-05534-y.
McNamara N. B., Munro D. A. D., Bestard-Cuche N. [и др.] Microglia regulate central nervous system myelin growth and integrity // Nature. — 2022. — Vol. 613, № 7942. — P. 120–129. — URL: https://doi.org/10.1038/s41586-022-05534-y
@article{mcnamara2022microglia,
title = {{Microglia regulate central nervous system myelin growth and integrity}},
author = {Niamh B. McNamara and David A. D. Munro and Nadine Bestard-Cuche and Akiko Uyeda and Jeroen F. J. Bogie and Alana Hoffmann and Rebecca K. Holloway and Irene Molina-González and Katharine E. Askew and Stephen Mitchell and William Mungall and Michael Dodds and Carsten Dittmayer and Jonathan Moss and Jamie L. Rose and Stefan Szymkowiak and Lukas Amann and Barry W. McColl and Marco Prinz and Tara L. Spires‐Jones and Werner Stenzel and Karen J. Horsburgh and Jerome J. A. Hendriks and Clare Pridans and Rieko Muramatsu and Anna Williams and Josef Priller and Véronique E. Miron},
journal = {Nature},
year = {2022},
volume = {613},
number = {7942},
pages = {120--129},
doi = {10.1038/s41586-022-05534-y},
url = {https://doi.org/10.1038/s41586-022-05534-y}
}TY - JOUR AU - McNamara, Niamh B. AU - Munro, David A. D. AU - Bestard-Cuche, Nadine AU - Uyeda, Akiko AU - Bogie, Jeroen F. J. AU - Hoffmann, Alana AU - Holloway, Rebecca K. AU - Molina-González, Irene AU - Askew, Katharine E. AU - Mitchell, Stephen AU - Mungall, William AU - Dodds, Michael AU - Dittmayer, Carsten AU - Moss, Jonathan AU - Rose, Jamie L. AU - Szymkowiak, Stefan AU - Amann, Lukas AU - McColl, Barry W. AU - Prinz, Marco AU - Spires‐Jones, Tara L. AU - Stenzel, Werner AU - Horsburgh, Karen J. AU - Hendriks, Jerome J. A. AU - Pridans, Clare AU - Muramatsu, Rieko AU - Williams, Anna AU - Priller, Josef AU - Miron, Véronique E. TI - Microglia regulate central nervous system myelin growth and integrity JO - Nature VL - 613 IS - 7942 SP - 120 EP - 129 PY - 2022 DA - 2022/12/14 DO - 10.1038/s41586-022-05534-y UR - https://doi.org/10.1038/s41586-022-05534-y ER -
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