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William Hill, Emilia L. Lim, Clare E. Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng‐Che Kuan, Fabio Marongiu, Edward James Evans, David Allan Moore and 316 more
A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development1. Here we propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known to be associated with lung cancer risk, promotes lung cancer by acting on cells that harbour pre-existing oncogenic mutations in healthy lung tissue. Focusing on EGFR-driven lung cancer, which is more common in never-smokers or light smokers, we found a significant association between PM2.5 levels and the incidence of lung cancer for 32,957 EGFR-driven lung cancer cases in four within-country cohorts. Functional mouse models revealed that air pollutants cause an influx of macrophages into the lung and release of interleukin-1β. This process results in a progenitor-like cell state within EGFR mutant lung alveolar type II epithelial cells that fuels tumorigenesis. Ultradeep mutational profiling of histologically normal lung tissue from 295 individuals across 3 clinical cohorts revealed oncogenic EGFR and KRAS driver mutations in 18% and 53% of healthy tissue samples, respectively. These findings collectively support a tumour-promoting role for PM2.5 air pollutants and provide impetus for public health policy initiatives to address air pollution to reduce disease burden. Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer
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Hill, W., Lim, E. L., Weeden, C. E., Lee, C., Augustine, M., Chen, K., Kuan, F., Marongiu, F., Evans, E. J., Moore, D. A., Rodrigues, F. S., Pich, O., Bakker, B., Cha, H., Myers, R. L., Maldegem, F. V., Boumelha, J., Veeriah, S., Rowan, A., … Swanton, C. (2023). Lung adenocarcinoma promotion by air pollutants. Nature, 616(7955), 159–167. https://doi.org/10.1038/s41586-023-05874-3
Hill, William, et al. "Lung adenocarcinoma promotion by air pollutants." Nature, vol. 616, no. 7955, 2023, pp. 159–167, https://doi.org/10.1038/s41586-023-05874-3.
Hill, William, Emilia L. Lim, Clare E. Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng‐Che Kuan, et al. "Lung adenocarcinoma promotion by air pollutants." Nature 616, no. 7955 (2023): 159–167. https://doi.org/10.1038/s41586-023-05874-3.
Hill W., Lim E. L., Weeden C. E. [и др.] Lung adenocarcinoma promotion by air pollutants // Nature. — 2023. — Vol. 616, № 7955. — P. 159–167. — URL: https://doi.org/10.1038/s41586-023-05874-3
@article{hill2023lung,
title = {{Lung adenocarcinoma promotion by air pollutants}},
author = {William Hill and Emilia L. Lim and Clare E. Weeden and Claudia Lee and Marcellus Augustine and Kezhong Chen and Feng‐Che Kuan and Fabio Marongiu and Edward James Evans and David Allan Moore and Felipe Silva Rodrigues and Oriol Pich and Björn Bakker and Hongui Cha and Renelle L. Myers and Febe van Maldegem and Jesse Boumelha and Selvaraju Veeriah and Andrew Rowan and Cristina Naceur‐Lombardelli and Takahiro Karasaki and Monica Sivakumar and Swapnanil De and Deborah R. Caswell and Ai Nagano and James R. Black and Carlos Martínez‐Ruiz and Min Hyung Ryu and Ryan D. Huff and Shijia Li and Marie-Julie Favé and Alastair J. Magness and Alejandro Suárez‐Bonnet and Simon Lawrence Priestnall and Margreet Lüchtenborg and Katrina Lavelle and Joanna Pethick and Steven Hardy and Fiona E. McRonald and Meng‐Hung Lin and Clara I. Troccoli and Moumita Ghosh and York E. Miller and Daniel T. Merrick and Robert L. Keith and Maise Al Bakir and Chris Bailey and Mark S. Hill and Lao H. Saal and Yilun Chen and Anthony M. George and Christopher Abbosh and Nnennaya Kanu and Se‐Hoon Lee and Nicholas McGranahan and Christine D. Berg and Peter David Sasieni and Richard S. Houlston and Clare Turnbull and Stephen C. Lam and Philip Awadalla and Eva Camilla Gronroos and Julian Downward and Tyler Jacks and Chris Carlsten and Ilaria Malanchi and Allan K. Hackshaw and Kevin Litchfield and Jason Francis Lester and Amrita Bajaj and Apostolos Nakas and Azmina Sodha-Ramdeen and Keng Ang and Mohamad Tufail and Mohammed Fiyaz Chowdhry and Molly Scotland and Rebecca Boyles and Sridhar Rathinam and Claire Wilson and Domenic Marrone and Sean Dulloo and Dean Anthony Fennell and Gurdeep Matharu and Jacqui Shaw and Joan Riley and Lindsay Primrose and Ekaterini Boleti and Heather Cheyne and Mohammed Khalil and Shirley Richardson and Tracey Cruickshank and Gillian Price and Keith M. Kerr and Sarah Benafif and Kayleigh Gilbert and Babu V Naidu and Akshay Jatin Patel and Aya Osman and Christer Lacson and Gerald Langman and Helen Shackleford and Madava G. Djearaman and Salma Bibi Kadiri and Gary Middleton and Angela Leek and Jack Davies Hodgkinson and Nicola Totten and Ángeles Montero and Elaine Smith and Eustace J. Fontaine and Felice Granato and Helen M. Doran and Juliette Novasio and Kendadai Rammohan and Leena Joseph and Paul William Bishop and Rajesh D. Shah and Stuart Moss and Vijay Joshi and Philip A.J. Crosbie and Fábio Gomes and Kate Brown and Mathew Carter and Anshuman Chaturvedi and Lynsey J.C. Priest and Pedro Oliveira and Colin R. Lindsay and Fiona Helen Blackhall and Matthew Krebs and Yvonne Summers and Alexandra Clipson and Jonathan D. Tugwood and Alastair R. W. Kerr and Dominic G. Rothwell and Elaine Kilgour and Caroline Dive and Hugo J.W.L. Aerts and Roland F. Schwarz and Tom L. Kaufmann and Gareth A. Wilson and Rachel Rosenthal and Peter Van Loo and Nicolai J. Birkbak and Zoltán Szállási and Judit Kisistók and Mateo Sokač and Roberto Salgado and Miklós Dióssy and Jonas Demeulemeester and Abigail Bunkum and Aengus Stewart and Alexander M. Frankell and Angeliki Karamani and Antonia Toncheva and Ariana Huebner and Benny Chain and Brittany B. Campbell and Carla Castignani and Clare Puttick and Corentin Richard and Crispin T. Hiley and David R. Pearce and Despoina Karagianni and Dhruva Biswas and Dina Levi and Elena Hoxha and Elizabeth Larose Cadieux and Emma Colliver and Emma L. Nye and Felipe Gálvez‐Cancino and Foteini Athanasopoulou and Francisco Gimeno-Valiente and George Kassiotis and Georgia Stavrou and Gerasimos Mastrokalos and Hao-Ran Zhai and Helen L. Lowe and Ignacio Garcia Matos and Jacki Goldman and James L. Reading and Javier Herrero and Jayant K. Rane and Jérôme Nicod and Jie Min Lam and John Anthony Hartley and Karl S. Peggs and Katey S.S. Enfield and Kayalvizhi Selvaraju and Kerstin Thol and Kevin W. Ng and Krijn Kristian Dijkstra and Kristiana Grigoriadis and Krupa Thakkar and Leah Ensell and Mansi Shah and Marcos Vásquez and Maria Litovchenko and Mariana Werner Sunderland and Michelle Dietzen and Michelle M. Leung and Mickael Escudero and Mihaela Angelova and Miljana Tanić and Olga Chervova and Olivia Lucas and Othman Al‐Sawaf and Paulina Prymas and Philip S. Hobson and Piotr Pawlik and Richard Kevin Stone and Robert B. Bentham and Robert E. Hynds and Roberto Vendramin and Sadegh Saghafinia and Saioa López and Samuel Gamble and Seng Kuong Anakin Ung and Sergio A. Quezada and Sharon P. Vanloo and Simone Zaccaria and Sonya Hessey and Sophia Ward and Stefan Boeing and Stephan Beck and Supreet Kaur Bola and Tamara Denner and Teresa Marafioti and Thanos P. Mourikis and Thomas B.K. Watkins and Victoria J. Spanswick and Vittorio Barbè and Wei-Ting Lu and Wing Kin Liu and Yin Wu and Yutaka Naito and Zoe Ramsden and Catarina Veiga and Gary J. Royle and Charles‐Antoine Collins‐Fekete and Francesco Fraioli and Paul Ashford and Tristan Clark and Martin David Forster and Siow Ming Lee and Elaine Borg and Mary Falzon and Dionysis Papadatos-Pastos and James Matthew Wilson and Tanya Ahmad and Alexander James Procter and Asia Ahmed and Magali N. Taylor and Arjun Nair and David R. Lawrence and Davide Patrini and Neal Navani and Ricky M. Thakrar and Sam M. Janes and Emilie Martinoni Hoogenboom and Fleur Monk and James W. Holding and Junaid Choudhary and Kunal P Bhakhri and Marco Scarci and Martin P. Hayward and Nikolaos Panagiotopoulos and Pat Gorman and Reena Khiroya and Robert C. M. Stephens and Yien Ning Sophia Wong and Steve Bandula and Abigail Sharp and Sean D. Smith and Nicole H. Gower and Harjot Kaur Dhanda and Kitty Chan and Camilla Pilotti and Rachel Leslie and Anca Grapa and Hanyun Zhang and Khalid AbdulJabbar and Xiaoxi Pan and Yinyin Yuan and David Chuter and Mairead MacKenzie and Serena Chee and Aiman Alzetani and Judith Cave and Lydia Scarlett and Jennifer M. J. Richards and Papawadee Ingram and Silvia Austin and Eric Kian Saik Lim and Paulo De Sousa and Simon J. Jordan and Alexandra J. Rice and Hilgardt Raubenheimer and Harshil Bhayani and Lyn R. Ambrose and Anand Devaraj and Hema Chavan and Sofina Begum and Silviu Buderi and Daniel Kaniu and Mpho Malima and Sarah Booth and Andrew Gordon Nicholson and Nadia J. Fernandes and Pratibha Shah and Chiara Proli and Madeleine Hewish and Sarah J. Danson and Michael J. Shackcloth and Lily Robinson and Peter Russell and Kevin G. Blyth and Craig Dick and John P. C. Le Quesne and Alan J. B. Kirk and Mo Asif and Rocco Bilancia and Nikos Kostoulas and Mathew Thomas and James V. DeGregori and Mariam Jamal‐Hanjani and Charles Swanton},
journal = {Nature},
year = {2023},
volume = {616},
number = {7955},
pages = {159--167},
doi = {10.1038/s41586-023-05874-3},
url = {https://doi.org/10.1038/s41586-023-05874-3}
}TY - JOUR AU - Hill, William AU - Lim, Emilia L. AU - Weeden, Clare E. AU - Lee, Claudia AU - Augustine, Marcellus AU - Chen, Kezhong AU - Kuan, Feng‐Che AU - Marongiu, Fabio AU - Evans, Edward James AU - Moore, David Allan AU - Rodrigues, Felipe Silva AU - Pich, Oriol AU - Bakker, Björn AU - Cha, Hongui AU - Myers, Renelle L. AU - Maldegem, Febe van AU - Boumelha, Jesse AU - Veeriah, Selvaraju AU - Rowan, Andrew AU - Naceur‐Lombardelli, Cristina AU - Karasaki, Takahiro AU - Sivakumar, Monica AU - De, Swapnanil AU - Caswell, Deborah R. AU - Nagano, Ai AU - Black, James R. AU - Martínez‐Ruiz, Carlos AU - Ryu, Min Hyung AU - Huff, Ryan D. AU - Li, Shijia AU - Favé, Marie-Julie AU - Magness, Alastair J. AU - Suárez‐Bonnet, Alejandro AU - Priestnall, Simon Lawrence AU - Lüchtenborg, Margreet AU - Lavelle, Katrina AU - Pethick, Joanna AU - Hardy, Steven AU - McRonald, Fiona E. AU - Lin, Meng‐Hung AU - Troccoli, Clara I. AU - Ghosh, Moumita AU - Miller, York E. AU - Merrick, Daniel T. AU - Keith, Robert L. AU - Bakir, Maise Al AU - Bailey, Chris AU - Hill, Mark S. AU - Saal, Lao H. AU - Chen, Yilun AU - George, Anthony M. AU - Abbosh, Christopher AU - Kanu, Nnennaya AU - Lee, Se‐Hoon AU - McGranahan, Nicholas AU - Berg, Christine D. AU - Sasieni, Peter David AU - Houlston, Richard S. AU - Turnbull, Clare AU - Lam, Stephen C. AU - Awadalla, Philip AU - Gronroos, Eva Camilla AU - Downward, Julian AU - Jacks, Tyler AU - Carlsten, Chris AU - Malanchi, Ilaria AU - Hackshaw, Allan K. AU - Litchfield, Kevin AU - Lester, Jason Francis AU - Bajaj, Amrita AU - Nakas, Apostolos AU - Sodha-Ramdeen, Azmina AU - Ang, Keng AU - Tufail, Mohamad AU - Chowdhry, Mohammed Fiyaz AU - Scotland, Molly AU - Boyles, Rebecca AU - Rathinam, Sridhar AU - Wilson, Claire AU - Marrone, Domenic AU - Dulloo, Sean AU - Fennell, Dean Anthony AU - Matharu, Gurdeep AU - Shaw, Jacqui AU - Riley, Joan AU - Primrose, Lindsay AU - Boleti, Ekaterini AU - Cheyne, Heather AU - Khalil, Mohammed AU - Richardson, Shirley AU - Cruickshank, Tracey AU - Price, Gillian AU - Kerr, Keith M. AU - Benafif, Sarah AU - Gilbert, Kayleigh AU - Naidu, Babu V AU - Patel, Akshay Jatin AU - Osman, Aya AU - Lacson, Christer AU - Langman, Gerald AU - Shackleford, Helen AU - Djearaman, Madava G. AU - Kadiri, Salma Bibi AU - Middleton, Gary AU - Leek, Angela AU - Hodgkinson, Jack Davies AU - Totten, Nicola AU - Montero, Ángeles AU - Smith, Elaine AU - Fontaine, Eustace J. AU - Granato, Felice AU - Doran, Helen M. AU - Novasio, Juliette AU - Rammohan, Kendadai AU - Joseph, Leena AU - Bishop, Paul William AU - Shah, Rajesh D. AU - Moss, Stuart AU - Joshi, Vijay AU - Crosbie, Philip A.J. AU - Gomes, Fábio AU - Brown, Kate AU - Carter, Mathew AU - Chaturvedi, Anshuman AU - Priest, Lynsey J.C. AU - Oliveira, Pedro AU - Lindsay, Colin R. AU - Blackhall, Fiona Helen AU - Krebs, Matthew AU - Summers, Yvonne AU - Clipson, Alexandra AU - Tugwood, Jonathan D. AU - Kerr, Alastair R. W. AU - Rothwell, Dominic G. AU - Kilgour, Elaine AU - Dive, Caroline AU - Aerts, Hugo J.W.L. AU - Schwarz, Roland F. AU - Kaufmann, Tom L. AU - Wilson, Gareth A. AU - Rosenthal, Rachel AU - Loo, Peter Van AU - Birkbak, Nicolai J. AU - Szállási, Zoltán AU - Kisistók, Judit AU - Sokač, Mateo AU - Salgado, Roberto AU - Dióssy, Miklós AU - Demeulemeester, Jonas AU - Bunkum, Abigail AU - Stewart, Aengus AU - Frankell, Alexander M. AU - Karamani, Angeliki AU - Toncheva, Antonia AU - Huebner, Ariana AU - Chain, Benny AU - Campbell, Brittany B. AU - Castignani, Carla AU - Puttick, Clare AU - Richard, Corentin AU - Hiley, Crispin T. AU - Pearce, David R. AU - Karagianni, Despoina AU - Biswas, Dhruva AU - Levi, Dina AU - Hoxha, Elena AU - Cadieux, Elizabeth Larose AU - Colliver, Emma AU - Nye, Emma L. AU - Gálvez‐Cancino, Felipe AU - Athanasopoulou, Foteini AU - Gimeno-Valiente, Francisco AU - Kassiotis, George AU - Stavrou, Georgia AU - Mastrokalos, Gerasimos AU - Zhai, Hao-Ran AU - Lowe, Helen L. AU - Matos, Ignacio Garcia AU - Goldman, Jacki AU - Reading, James L. AU - Herrero, Javier AU - Rane, Jayant K. AU - Nicod, Jérôme AU - Lam, Jie Min AU - Hartley, John Anthony AU - Peggs, Karl S. AU - Enfield, Katey S.S. AU - Selvaraju, Kayalvizhi AU - Thol, Kerstin AU - Ng, Kevin W. AU - Dijkstra, Krijn Kristian AU - Grigoriadis, Kristiana AU - Thakkar, Krupa AU - Ensell, Leah AU - Shah, Mansi AU - Vásquez, Marcos AU - Litovchenko, Maria AU - Sunderland, Mariana Werner AU - Dietzen, Michelle AU - Leung, Michelle M. AU - Escudero, Mickael AU - Angelova, Mihaela AU - Tanić, Miljana AU - Chervova, Olga AU - Lucas, Olivia AU - Al‐Sawaf, Othman AU - Prymas, Paulina AU - Hobson, Philip S. AU - Pawlik, Piotr AU - Stone, Richard Kevin AU - Bentham, Robert B. AU - Hynds, Robert E. AU - Vendramin, Roberto AU - Saghafinia, Sadegh AU - López, Saioa AU - Gamble, Samuel AU - Ung, Seng Kuong Anakin AU - Quezada, Sergio A. AU - Vanloo, Sharon P. AU - Zaccaria, Simone AU - Hessey, Sonya AU - Ward, Sophia AU - Boeing, Stefan AU - Beck, Stephan AU - Bola, Supreet Kaur AU - Denner, Tamara AU - Marafioti, Teresa AU - Mourikis, Thanos P. AU - Watkins, Thomas B.K. AU - Spanswick, Victoria J. AU - Barbè, Vittorio AU - Lu, Wei-Ting AU - Liu, Wing Kin AU - Wu, Yin AU - Naito, Yutaka AU - Ramsden, Zoe AU - Veiga, Catarina AU - Royle, Gary J. AU - Collins‐Fekete, Charles‐Antoine AU - Fraioli, Francesco AU - Ashford, Paul AU - Clark, Tristan AU - Forster, Martin David AU - Lee, Siow Ming AU - Borg, Elaine AU - Falzon, Mary AU - Papadatos-Pastos, Dionysis AU - Wilson, James Matthew AU - Ahmad, Tanya AU - Procter, Alexander James AU - Ahmed, Asia AU - Taylor, Magali N. AU - Nair, Arjun AU - Lawrence, David R. AU - Patrini, Davide AU - Navani, Neal AU - Thakrar, Ricky M. AU - Janes, Sam M. AU - Hoogenboom, Emilie Martinoni AU - Monk, Fleur AU - Holding, James W. AU - Choudhary, Junaid AU - Bhakhri, Kunal P AU - Scarci, Marco AU - Hayward, Martin P. AU - Panagiotopoulos, Nikolaos AU - Gorman, Pat AU - Khiroya, Reena AU - Stephens, Robert C. M. AU - Wong, Yien Ning Sophia AU - Bandula, Steve AU - Sharp, Abigail AU - Smith, Sean D. AU - Gower, Nicole H. AU - Dhanda, Harjot Kaur AU - Chan, Kitty AU - Pilotti, Camilla AU - Leslie, Rachel AU - Grapa, Anca AU - Zhang, Hanyun AU - AbdulJabbar, Khalid AU - Pan, Xiaoxi AU - Yuan, Yinyin AU - Chuter, David AU - MacKenzie, Mairead AU - Chee, Serena AU - Alzetani, Aiman AU - Cave, Judith AU - Scarlett, Lydia AU - Richards, Jennifer M. J. AU - Ingram, Papawadee AU - Austin, Silvia AU - Lim, Eric Kian Saik AU - Sousa, Paulo De AU - Jordan, Simon J. AU - Rice, Alexandra J. AU - Raubenheimer, Hilgardt AU - Bhayani, Harshil AU - Ambrose, Lyn R. AU - Devaraj, Anand AU - Chavan, Hema AU - Begum, Sofina AU - Buderi, Silviu AU - Kaniu, Daniel AU - Malima, Mpho AU - Booth, Sarah AU - Nicholson, Andrew Gordon AU - Fernandes, Nadia J. AU - Shah, Pratibha AU - Proli, Chiara AU - Hewish, Madeleine AU - Danson, Sarah J. AU - Shackcloth, Michael J. AU - Robinson, Lily AU - Russell, Peter AU - Blyth, Kevin G. AU - Dick, Craig AU - Quesne, John P. C. Le AU - Kirk, Alan J. B. AU - Asif, Mo AU - Bilancia, Rocco AU - Kostoulas, Nikos AU - Thomas, Mathew AU - DeGregori, James V. AU - Jamal‐Hanjani, Mariam AU - Swanton, Charles TI - Lung adenocarcinoma promotion by air pollutants JO - Nature VL - 616 IS - 7955 SP - 159 EP - 167 PY - 2023 DA - 2023/04/05 DO - 10.1038/s41586-023-05874-3 UR - https://doi.org/10.1038/s41586-023-05874-3 ER -
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