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James Christopher S. Pang, Kevin M. Aquino, Marianne Oldehinkel, Peter A. Robinson, Ben Fulcher, Michael J Breakspear, Alex Fornito
The brain’s anatomy constrains its function, but precisely how remains unclear. Here, we show that human cortical and subcortical activity, measured with magnetic resonance imaging under spontaneous and diverse task-evoked conditions, can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry (i.e., its shape) rather than modes from complex inter-regional connectivity, as classically assumed. We then use these modes to show that task-evoked activations across >10,000 brain maps are not confined to focal areas, as widely believed, but instead excite brain-wide modes with wavelengths spanning >60 mm. Finally, we confirm theoretical predictions that the close link between geometry and function is explained by a dominant role for wave-like dynamics, showing that such dynamics can reproduce numerous canonical spatiotemporal properties of spontaneous and evoked recordings. Our findings challenge prevailing views of brain function and identify a previously under-appreciated role of brain geometry that is predicted by a unifying and physically principled approach.
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Pang, J. C. S., Aquino, K. M., Oldehinkel, M., Robinson, P. A., Fulcher, B., Breakspear, M. J., & Fornito, A. (2023). Geometric constraints on human brain function. Nature, 618(7965), 566–574. https://doi.org/10.1038/s41586-023-06098-1
Pang, James Christopher S., et al. "Geometric constraints on human brain function." Nature, vol. 618, no. 7965, 2023, pp. 566–574, https://doi.org/10.1038/s41586-023-06098-1.
Pang, James Christopher S., Kevin M. Aquino, Marianne Oldehinkel, Peter A. Robinson, Ben Fulcher, Michael J Breakspear, and Alex Fornito. "Geometric constraints on human brain function." Nature 618, no. 7965 (2023): 566–574. https://doi.org/10.1038/s41586-023-06098-1.
Pang J. C. S., Aquino K. M., Oldehinkel M. [и др.] Geometric constraints on human brain function // Nature. — 2023. — Vol. 618, № 7965. — P. 566–574. — URL: https://doi.org/10.1038/s41586-023-06098-1
@article{pang2023geometric,
title = {{Geometric constraints on human brain function}},
author = {James Christopher S. Pang and Kevin M. Aquino and Marianne Oldehinkel and Peter A. Robinson and Ben Fulcher and Michael J Breakspear and Alex Fornito},
journal = {Nature},
year = {2023},
volume = {618},
number = {7965},
pages = {566--574},
doi = {10.1038/s41586-023-06098-1},
url = {https://doi.org/10.1038/s41586-023-06098-1}
}TY - JOUR AU - Pang, James Christopher S. AU - Aquino, Kevin M. AU - Oldehinkel, Marianne AU - Robinson, Peter A. AU - Fulcher, Ben AU - Breakspear, Michael J AU - Fornito, Alex TI - Geometric constraints on human brain function JO - Nature VL - 618 IS - 7965 SP - 566 EP - 574 PY - 2023 DA - 2023/05/31 DO - 10.1038/s41586-023-06098-1 UR - https://doi.org/10.1038/s41586-023-06098-1 ER -
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