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Sven Dorkenwald, Arie Matsliah, Amy Robinson Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin and 283 more
Connections between neurons can be mapped by acquiring and analysing electron microscopic brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative 1–6 , but nevertheless inadequate for understanding brain function more globally. Here we present a neuronal wiring diagram of a whole brain containing 5 × 10 7 chemical synapses 7 between 139,255 neurons reconstructed from an adult female Drosophila melanogaster 8,9 . The resource also incorporates annotations of cell classes and types, nerves, hemilineages and predictions of neurotransmitter identities 10–12 . Data products are available for download, programmatic access and interactive browsing and have been made interoperable with other fly data resources. We derive a projectome—a map of projections between regions—from the connectome and report on tracing of synaptic pathways and the analysis of information flow from inputs (sensory and ascending neurons) to outputs (motor, endocrine and descending neurons) across both hemispheres and between the central brain and the optic lobes. Tracing from a subset of photoreceptors to descending motor pathways illustrates how structure can uncover putative circuit mechanisms underlying sensorimotor behaviours. The technologies and open ecosystem reported here set the stage for future large-scale connectome projects in other species.
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Dorkenwald, S., Matsliah, A., Sterling, A. R., Schlegel, P., Yu, S.-C., McKellar, C. E., Lin, A., Costa, M., Eichler, K., Yin, Y., Silversmith, W., Schneider-Mizell, C. M., Jordan, C. S., Brittain, D., Halageri, A., Kuehner, K., Ogedengbe, O., Morey, R., Gager, J., … Zandawala, M. (2024). Neuronal wiring diagram of an adult brain. Nature, 634(8032), 124–138. https://doi.org/10.1038/s41586-024-07558-y
Dorkenwald, Sven, et al. "Neuronal wiring diagram of an adult brain." Nature, vol. 634, no. 8032, 2024, pp. 124–138, https://doi.org/10.1038/s41586-024-07558-y.
Dorkenwald, Sven, Arie Matsliah, Amy Robinson Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, et al. "Neuronal wiring diagram of an adult brain." Nature 634, no. 8032 (2024): 124–138. https://doi.org/10.1038/s41586-024-07558-y.
Dorkenwald S., Matsliah A., Sterling A. R. [и др.] Neuronal wiring diagram of an adult brain // Nature. — 2024. — Vol. 634, № 8032. — P. 124–138. — URL: https://doi.org/10.1038/s41586-024-07558-y
@article{dorkenwald2024neuronal,
title = {{Neuronal wiring diagram of an adult brain}},
author = {Sven Dorkenwald and Arie Matsliah and Amy Robinson Sterling and Philipp Schlegel and Szi-chieh Yu and Claire E. McKellar and Albert Lin and Marta Costa and Katharina Eichler and Yijie Yin and William Silversmith and Casey M Schneider-Mizell and Chris S. Jordan and Derrick Brittain and Akhilesh Halageri and Kai Kuehner and Oluwaseun Ogedengbe and Ryan Morey and Jay Gager and Krzysztof Kruk and Eric Perlman and Runzhe Yang and David S. Deutsch and Doug Bland and Marissa Sorek and Ran Lu and Thomas Macrina and Kisuk Lee and J. Alexander Bae and Shang Mu and Barak Nehoran and Eric Mitchell and Sergiy Popovych and Jingpeng Wu and Zhen Jia and Manuel A Castro and Nico Kemnitz and Dodam Ih and Alexander Shakeel Bates and Nils Eckstein and Jan Funke and Forrest Collman and Davi D. Bock and Gregory S.X.E. Jefferis and H. Sebastian Seung and Mala Murthy and Zairene Lenizo and Austin T. Burke and Kyle Patrick Willie and Nikitas Serafetinidis and Nashra Hadjerol and Ryan Willie and Ben Silverman and John Anthony Ocho and Joshua Bañez and Rey Adrian Candilada and Anne Kristiansen and Nelsie Panes and Arti Yadav and Remer Tancontian and Shirleyjoy Serona and Jet Ivan Dolorosa and Kendrick Joules Vinson and Dustin Garner and Regine Salem and Ariel Dagohoy and Jaime Skelton and Mendell Lopez and Laia Serratosa Capdevila and Griffin Badalamente and Tom Stocks and Anjali Pandey and Darrel Jay Akiatan and James Hebditch and Celia David and Dharini Sapkal and Shaina Mae Monungolh and Varun Sane and Mark Lloyd Pielago and Miguel Albero and Jacquilyn Laude and Márcia dos Santos and Zeba Vohra and Kaiyu Wang and Allien Mae Gogo and Emil Kind and Alvin Josh Mandahay and Chereb Martinez and John David Asis and Chitra Nair and Dhwani Patel and Marchan Manaytay and Imaan F. M. Tamimi and Clyde Angelo Lim and Philip Lenard Ampo and Michelle Darapan Pantujan and Alexandre Javier and Daril Bautista and Rashmita Rana and Jansen Seguido and Bhargavi Parmar and John Clyde Saguimpa and Merlin Moore and Markus William Pleijzier and Mark Larson and Joseph Hsu and Itisha Joshi and Dhara Kakadiya and Amalia Braun and Cathy Pilapil and Marina Gkantia and Kaushik Parmar and Quinn Vanderbeck and Irene Salgarella and Christopher Dunne and Eva Munnelly and Chan Hyuk Kang and Lena Lörsch and Jinmook Lee and Lucia Kmecova and Gizem Sancer and Christa Baker and Jenna Joroff and Steven A. Calle-Schuler and Yashvi Patel and Olivia Sato and Siqi Fang and Janice Salocot and Farzaan Salman and Sebastian Molina-Obando and Paul Brooks and Mai Bui and Matthew Lichtenberger and Edward Tamboboy and Katie Molloy and Alexis E. Santana-Cruz and Anthony Hernandez and Seongbong Yu and Arzoo Diwan and Monika Patel and Travis R. Aiken and Sarah Morejohn and Sanna Koskela and Tansy Yang and Daniel Lehmann and Jonas Chojetzki and Sangeeta Sisodiya and Selden Koolman and Philip K. Shiu and Sky Cho and Annika Bast and Brian Reicher and Marlon Blanquart and Lucy Houghton and Hyungjun Choi and Maria Ioannidou and Matt Collie and Joanna Eckhardt and Benjamin Gorko and Li Guo and Zhihao Zheng and Alisa M. Poh and Marina Lin and István Taisz and Wes Murfin and Alvaro Sanz Diez and Nils Reinhard and Peter Gibb and Nidhi Patel and Sandeep Kumar and Minsik Yun and Megan Wang and Devon Jones and Lucas Encarnacion-Rivera and Annalena Oswald and Akanksha Jadia and Mert Erginkaya and Nik Drummond and Walter Leal Filho and Ibrahim Tastekin and Xin Zhong and Yuta Mabuchi and Fernando J. Figueroa Santiago and Urja Verma and Nick Byrne and Edda Kunze and Thomas Crahan and Ryan Margossian and Haein Kim and Iliyan Georgiev and Fabianna Szorenyi and Atsuko Adachi and Benjamin Bargeron and Tomke Stürner and Damian Demarest and Burak Gür and Andrea N. Becker and Robert Turnbull and Ashley Morren and Andrea Sandoval and Anthony Moreno-Sanchez and Diego A. Pacheco and Eleni Samara and Haley Croke and Alexander Thomson and Connor W. Laughland and Suchetana Bias Dutta and Paula Guiomar Alarcón de Antón and Binglin Huang and Patricia Pujols and Isabel Haber and Amanda González-Segarra and Daniel T. Choe and Veronika Lukyanova and Nino Mancini and Zequan Liu and Tatsuo Okubo and Miriam A Flynn and Gianna Vitelli and Meghan Laturney and Feng Li and Shuo Cao and Carolina Manyari-Diaz and Hyunsoo Yim and Anh Duc Le and Kate Maier and Seungyun Yu and Yeonju Nam and Daniel Bąba and Amanda Abusaif and Audrey Francis and Jesse Gayk and Sommer S. Huntress and Raquel Barajas and Mindy Kim and Xinyue Cui and Gabriella R Sterne and Anna Li and Keehyun Park and Georgia Dempsey and Alan Mathew and Jinseong Kim and Taewan Kim and Guan-ting Wu and Serene Dhawan and Margarida Brotas and Cheng-hao Zhang and Shanice Bailey and Alexander Del Toro and Runzhe Yang and Stephan Gerhard and Andrew S Champion and David J. Anderson and Rudy Behnia and Salil S. Bidaye and Alexander Borst and Eugenia Chiappe and Kenneth J. Colodner and Andrew M. Dacks and Barry J. Dickson and Denise Garcia and Stefanie Hampel and Volker Hartenstein and Bassem Hassan and Charlotte Helfrich-Forster and Wolf Huetteroth and Jinseop Kim and Sung Soo Kim and Young-Joon Kim and Jae Young Kwon and Wei-Chung Allen Lee and Gerit Arne Linneweber and Gaby Maimon and Richard Mann and Stéphane Noselli and Michael Pankratz and Lucia Prieto-Godino and Jenny Read and Michael B. Reiser and Katie von Reyn and Carlos Ribeiro and Kristin Scott and Andrew Michael Seeds and Mareike Selcho and Marion Silies and Julie H. Simpson and Scott Waddell and Mathias F. Wernet and Rachel I. Wilson and Fred W. Wolf and Zepeng Yao and Nilay Yapici and Meet Zandawala},
journal = {Nature},
year = {2024},
volume = {634},
number = {8032},
pages = {124--138},
doi = {10.1038/s41586-024-07558-y},
url = {https://doi.org/10.1038/s41586-024-07558-y}
}TY - JOUR AU - Dorkenwald, Sven AU - Matsliah, Arie AU - Sterling, Amy Robinson AU - Schlegel, Philipp AU - Yu, Szi-chieh AU - McKellar, Claire E. AU - Lin, Albert AU - Costa, Marta AU - Eichler, Katharina AU - Yin, Yijie AU - Silversmith, William AU - Schneider-Mizell, Casey M AU - Jordan, Chris S. AU - Brittain, Derrick AU - Halageri, Akhilesh AU - Kuehner, Kai AU - Ogedengbe, Oluwaseun AU - Morey, Ryan AU - Gager, Jay AU - Kruk, Krzysztof AU - Perlman, Eric AU - Yang, Runzhe AU - Deutsch, David S. AU - Bland, Doug AU - Sorek, Marissa AU - Lu, Ran AU - Macrina, Thomas AU - Lee, Kisuk AU - Bae, J. Alexander AU - Mu, Shang AU - Nehoran, Barak AU - Mitchell, Eric AU - Popovych, Sergiy AU - Wu, Jingpeng AU - Jia, Zhen AU - Castro, Manuel A AU - Kemnitz, Nico AU - Ih, Dodam AU - Bates, Alexander Shakeel AU - Eckstein, Nils AU - Funke, Jan AU - Collman, Forrest AU - Bock, Davi D. AU - Jefferis, Gregory S.X.E. AU - Seung, H. Sebastian AU - Murthy, Mala AU - Lenizo, Zairene AU - Burke, Austin T. AU - Willie, Kyle Patrick AU - Serafetinidis, Nikitas AU - Hadjerol, Nashra AU - Willie, Ryan AU - Silverman, Ben AU - Ocho, John Anthony AU - Bañez, Joshua AU - Candilada, Rey Adrian AU - Kristiansen, Anne AU - Panes, Nelsie AU - Yadav, Arti AU - Tancontian, Remer AU - Serona, Shirleyjoy AU - Dolorosa, Jet Ivan AU - Vinson, Kendrick Joules AU - Garner, Dustin AU - Salem, Regine AU - Dagohoy, Ariel AU - Skelton, Jaime AU - Lopez, Mendell AU - Capdevila, Laia Serratosa AU - Badalamente, Griffin AU - Stocks, Tom AU - Pandey, Anjali AU - Akiatan, Darrel Jay AU - Hebditch, James AU - David, Celia AU - Sapkal, Dharini AU - Monungolh, Shaina Mae AU - Sane, Varun AU - Pielago, Mark Lloyd AU - Albero, Miguel AU - Laude, Jacquilyn AU - Santos, Márcia dos AU - Vohra, Zeba AU - Wang, Kaiyu AU - Gogo, Allien Mae AU - Kind, Emil AU - Mandahay, Alvin Josh AU - Martinez, Chereb AU - Asis, John David AU - Nair, Chitra AU - Patel, Dhwani AU - Manaytay, Marchan AU - Tamimi, Imaan F. M. AU - Lim, Clyde Angelo AU - Ampo, Philip Lenard AU - Pantujan, Michelle Darapan AU - Javier, Alexandre AU - Bautista, Daril AU - Rana, Rashmita AU - Seguido, Jansen AU - Parmar, Bhargavi AU - Saguimpa, John Clyde AU - Moore, Merlin AU - Pleijzier, Markus William AU - Larson, Mark AU - Hsu, Joseph AU - Joshi, Itisha AU - Kakadiya, Dhara AU - Braun, Amalia AU - Pilapil, Cathy AU - Gkantia, Marina AU - Parmar, Kaushik AU - Vanderbeck, Quinn AU - Salgarella, Irene AU - Dunne, Christopher AU - Munnelly, Eva AU - Kang, Chan Hyuk AU - Lörsch, Lena AU - Lee, Jinmook AU - Kmecova, Lucia AU - Sancer, Gizem AU - Baker, Christa AU - Joroff, Jenna AU - Calle-Schuler, Steven A. AU - Patel, Yashvi AU - Sato, Olivia AU - Fang, Siqi AU - Salocot, Janice AU - Salman, Farzaan AU - Molina-Obando, Sebastian AU - Brooks, Paul AU - Bui, Mai AU - Lichtenberger, Matthew AU - Tamboboy, Edward AU - Molloy, Katie AU - Santana-Cruz, Alexis E. AU - Hernandez, Anthony AU - Yu, Seongbong AU - Diwan, Arzoo AU - Patel, Monika AU - Aiken, Travis R. AU - Morejohn, Sarah AU - Koskela, Sanna AU - Yang, Tansy AU - Lehmann, Daniel AU - Chojetzki, Jonas AU - Sisodiya, Sangeeta AU - Koolman, Selden AU - Shiu, Philip K. AU - Cho, Sky AU - Bast, Annika AU - Reicher, Brian AU - Blanquart, Marlon AU - Houghton, Lucy AU - Choi, Hyungjun AU - Ioannidou, Maria AU - Collie, Matt AU - Eckhardt, Joanna AU - Gorko, Benjamin AU - Guo, Li AU - Zheng, Zhihao AU - Poh, Alisa M. AU - Lin, Marina AU - Taisz, István AU - Murfin, Wes AU - Diez, Alvaro Sanz AU - Reinhard, Nils AU - Gibb, Peter AU - Patel, Nidhi AU - Kumar, Sandeep AU - Yun, Minsik AU - Wang, Megan AU - Jones, Devon AU - Encarnacion-Rivera, Lucas AU - Oswald, Annalena AU - Jadia, Akanksha AU - Erginkaya, Mert AU - Drummond, Nik AU - Filho, Walter Leal AU - Tastekin, Ibrahim AU - Zhong, Xin AU - Mabuchi, Yuta AU - Santiago, Fernando J. Figueroa AU - Verma, Urja AU - Byrne, Nick AU - Kunze, Edda AU - Crahan, Thomas AU - Margossian, Ryan AU - Kim, Haein AU - Georgiev, Iliyan AU - Szorenyi, Fabianna AU - Adachi, Atsuko AU - Bargeron, Benjamin AU - Stürner, Tomke AU - Demarest, Damian AU - Gür, Burak AU - Becker, Andrea N. AU - Turnbull, Robert AU - Morren, Ashley AU - Sandoval, Andrea AU - Moreno-Sanchez, Anthony AU - Pacheco, Diego A. AU - Samara, Eleni AU - Croke, Haley AU - Thomson, Alexander AU - Laughland, Connor W. AU - Dutta, Suchetana Bias AU - Antón, Paula Guiomar Alarcón de AU - Huang, Binglin AU - Pujols, Patricia AU - Haber, Isabel AU - González-Segarra, Amanda AU - Choe, Daniel T. AU - Lukyanova, Veronika AU - Mancini, Nino AU - Liu, Zequan AU - Okubo, Tatsuo AU - Flynn, Miriam A AU - Vitelli, Gianna AU - Laturney, Meghan AU - Li, Feng AU - Cao, Shuo AU - Manyari-Diaz, Carolina AU - Yim, Hyunsoo AU - Le, Anh Duc AU - Maier, Kate AU - Yu, Seungyun AU - Nam, Yeonju AU - Bąba, Daniel AU - Abusaif, Amanda AU - Francis, Audrey AU - Gayk, Jesse AU - Huntress, Sommer S. AU - Barajas, Raquel AU - Kim, Mindy AU - Cui, Xinyue AU - Sterne, Gabriella R AU - Li, Anna AU - Park, Keehyun AU - Dempsey, Georgia AU - Mathew, Alan AU - Kim, Jinseong AU - Kim, Taewan AU - Wu, Guan-ting AU - Dhawan, Serene AU - Brotas, Margarida AU - Zhang, Cheng-hao AU - Bailey, Shanice AU - Toro, Alexander Del AU - Yang, Runzhe AU - Gerhard, Stephan AU - Champion, Andrew S AU - Anderson, David J. AU - Behnia, Rudy AU - Bidaye, Salil S. AU - Borst, Alexander AU - Chiappe, Eugenia AU - Colodner, Kenneth J. AU - Dacks, Andrew M. AU - Dickson, Barry J. AU - Garcia, Denise AU - Hampel, Stefanie AU - Hartenstein, Volker AU - Hassan, Bassem AU - Helfrich-Forster, Charlotte AU - Huetteroth, Wolf AU - Kim, Jinseop AU - Kim, Sung Soo AU - Kim, Young-Joon AU - Kwon, Jae Young AU - Lee, Wei-Chung Allen AU - Linneweber, Gerit Arne AU - Maimon, Gaby AU - Mann, Richard AU - Noselli, Stéphane AU - Pankratz, Michael AU - Prieto-Godino, Lucia AU - Read, Jenny AU - Reiser, Michael B. AU - Reyn, Katie von AU - Ribeiro, Carlos AU - Scott, Kristin AU - Seeds, Andrew Michael AU - Selcho, Mareike AU - Silies, Marion AU - Simpson, Julie H. AU - Waddell, Scott AU - Wernet, Mathias F. AU - Wilson, Rachel I. AU - Wolf, Fred W. AU - Yao, Zepeng AU - Yapici, Nilay AU - Zandawala, Meet TI - Neuronal wiring diagram of an adult brain JO - Nature VL - 634 IS - 8032 SP - 124 EP - 138 PY - 2024 DA - 2024/10/02 DO - 10.1038/s41586-024-07558-y UR - https://doi.org/10.1038/s41586-024-07558-y ER -
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