One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Alexander Kurilshikov, Carolina Medina‐Gómez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayşe Demirkan, Caroline Ivanne Le Roy, Juan A. Raygoza Garay, Casey T. Finnicum, Xingrong Liu and 94 more
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10−8) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10−20), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10−10 < P < 5 × 10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis. Analysis of human genotypes and 16S microbiome data of 18,473 individuals from 25 cohorts through a genome-wide association study, a phenome-wide association study and Mendelian randomization identifies host genetic and microbial trait associations.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Kurilshikov, A., Medina‐Gómez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Roy, C. I. L., Garay, J. A. R., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Rühlemann, M. C., Turpin, W., Moon, J., Kim, H., Lüll, K., … Zhernakova, A. (2021). Large-scale association analyses identify host factors influencing human gut microbiome composition. Nature Genetics, 53(2), 156–165. https://doi.org/10.1038/s41588-020-00763-1
Kurilshikov, Alexander, et al. "Large-scale association analyses identify host factors influencing human gut microbiome composition." Nature Genetics, vol. 53, no. 2, 2021, pp. 156–165, https://doi.org/10.1038/s41588-020-00763-1.
Kurilshikov, Alexander, Carolina Medina‐Gómez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayşe Demirkan, Caroline Ivanne Le Roy, et al. "Large-scale association analyses identify host factors influencing human gut microbiome composition." Nature Genetics 53, no. 2 (2021): 156–165. https://doi.org/10.1038/s41588-020-00763-1.
Kurilshikov A., Medina‐Gómez C., Bacigalupe R. [и др.] Large-scale association analyses identify host factors influencing human gut microbiome composition // Nature Genetics. — 2021. — Vol. 53, № 2. — P. 156–165. — URL: https://doi.org/10.1038/s41588-020-00763-1
@article{kurilshikov2021largescale,
title = {{Large-scale association analyses identify host factors influencing human gut microbiome composition}},
author = {Alexander Kurilshikov and Carolina Medina‐Gómez and Rodrigo Bacigalupe and Djawad Radjabzadeh and Jun Wang and Ayşe Demirkan and Caroline Ivanne Le Roy and Juan A. Raygoza Garay and Casey T. Finnicum and Xingrong Liu and Daria V. Zhernakova and Marc Jan Bonder and Tue H. Hansen and Fabian Frost and Malte Christoph Rühlemann and Williams Turpin and Jee‐Young Moon and Han‐Na Kim and Kreete Lüll and Elad Barkan and Shiraz Ali Shah and Myriam Fornage and Joanna Szopinska-Tokov and Zachary D. Wallen and Dmitrii Borisevich and Lars Agréus and Anna Andréasson and Corinna Bang and Larbi Bedrani and Jordana T. Bell and Hans Flinker Bisgaard and Michael Boehnke and Dorret Irene Boomsma and Robert David Burk and Annique Claringbould and Kenneth Croitoru and Gareth E. Davies and Cornelia M. van Duijn and Liesbeth Duijts and Gwen Falony and Jingyuan Fu and Adriaan van der Graaf and Torben F. Hansen and Georg Homuth and David A. Hughes and Richard G. IJzerman and Matthew A Jackson and Vincent W. V. Jaddoe and Marie Joossens and Torben Jørgensen and Dániel Keszthelyi and Rob D. Knight and Markku Laakso and Matthias Laudes and Lenore J. Launer and Wolfgang Lieb and Aldons Jake Lusis and Ad Masclee and Henriëtte A. Moll and Zlatan Mujagic and Qibin Qi and Daphna Rothschild and Hocheol Shin and Søren Johannes Sørensen and Claire Joanne Steves and Jonathan Thorsen and Nicholas John Timpson and Raul Yhossef Tito and Sara Vieira‐Silva and Uwe Völker and Henry Völzke and Urmo Võsa and Kaitlin Hazel Wade and Susanna Walter and Kyoko Watanabe and Stefan Weiß and Frank Ulrich Weiß and Omer Weissbrod and Harm-Jan Westra and Gonneke A. H. M. Willemsen and Haydeh Payami and Daisy M.A.E. Jonkers and Alejandro Arias Vásquez and Eco J. C. de Geus and Katie A. Meyer and Jakob Stokholm and Eran Segal and Elin Org and Cisca Wijmenga and Hyung‐Lae Kim and Robert C. Kaplan and Tim D. Spector and André Gerardus Uitterlinden and Fernando Rivadeneira and André Franke and Markus M. Lerch and Lude Franke and Serena Sanna and Mauro D’Amato and Oluf Borbye Pedersen and Andrew D. Paterson and Robert Kraaij and Jeroen Raes and Alexandra Zhernakova},
journal = {Nature Genetics},
year = {2021},
volume = {53},
number = {2},
pages = {156--165},
doi = {10.1038/s41588-020-00763-1},
url = {https://doi.org/10.1038/s41588-020-00763-1}
}TY - JOUR AU - Kurilshikov, Alexander AU - Medina‐Gómez, Carolina AU - Bacigalupe, Rodrigo AU - Radjabzadeh, Djawad AU - Wang, Jun AU - Demirkan, Ayşe AU - Roy, Caroline Ivanne Le AU - Garay, Juan A. Raygoza AU - Finnicum, Casey T. AU - Liu, Xingrong AU - Zhernakova, Daria V. AU - Bonder, Marc Jan AU - Hansen, Tue H. AU - Frost, Fabian AU - Rühlemann, Malte Christoph AU - Turpin, Williams AU - Moon, Jee‐Young AU - Kim, Han‐Na AU - Lüll, Kreete AU - Barkan, Elad AU - Shah, Shiraz Ali AU - Fornage, Myriam AU - Szopinska-Tokov, Joanna AU - Wallen, Zachary D. AU - Borisevich, Dmitrii AU - Agréus, Lars AU - Andréasson, Anna AU - Bang, Corinna AU - Bedrani, Larbi AU - Bell, Jordana T. AU - Bisgaard, Hans Flinker AU - Boehnke, Michael AU - Boomsma, Dorret Irene AU - Burk, Robert David AU - Claringbould, Annique AU - Croitoru, Kenneth AU - Davies, Gareth E. AU - Duijn, Cornelia M. van AU - Duijts, Liesbeth AU - Falony, Gwen AU - Fu, Jingyuan AU - Graaf, Adriaan van der AU - Hansen, Torben F. AU - Homuth, Georg AU - Hughes, David A. AU - IJzerman, Richard G. AU - Jackson, Matthew A AU - Jaddoe, Vincent W. V. AU - Joossens, Marie AU - Jørgensen, Torben AU - Keszthelyi, Dániel AU - Knight, Rob D. AU - Laakso, Markku AU - Laudes, Matthias AU - Launer, Lenore J. AU - Lieb, Wolfgang AU - Lusis, Aldons Jake AU - Masclee, Ad AU - Moll, Henriëtte A. AU - Mujagic, Zlatan AU - Qi, Qibin AU - Rothschild, Daphna AU - Shin, Hocheol AU - Sørensen, Søren Johannes AU - Steves, Claire Joanne AU - Thorsen, Jonathan AU - Timpson, Nicholas John AU - Tito, Raul Yhossef AU - Vieira‐Silva, Sara AU - Völker, Uwe AU - Völzke, Henry AU - Võsa, Urmo AU - Wade, Kaitlin Hazel AU - Walter, Susanna AU - Watanabe, Kyoko AU - Weiß, Stefan AU - Weiß, Frank Ulrich AU - Weissbrod, Omer AU - Westra, Harm-Jan AU - Willemsen, Gonneke A. H. M. AU - Payami, Haydeh AU - Jonkers, Daisy M.A.E. AU - Vásquez, Alejandro Arias AU - Geus, Eco J. C. de AU - Meyer, Katie A. AU - Stokholm, Jakob AU - Segal, Eran AU - Org, Elin AU - Wijmenga, Cisca AU - Kim, Hyung‐Lae AU - Kaplan, Robert C. AU - Spector, Tim D. AU - Uitterlinden, André Gerardus AU - Rivadeneira, Fernando AU - Franke, André AU - Lerch, Markus M. AU - Franke, Lude AU - Sanna, Serena AU - D’Amato, Mauro AU - Pedersen, Oluf Borbye AU - Paterson, Andrew D. AU - Kraaij, Robert AU - Raes, Jeroen AU - Zhernakova, Alexandra TI - Large-scale association analyses identify host factors influencing human gut microbiome composition JO - Nature Genetics VL - 53 IS - 2 SP - 156 EP - 165 PY - 2021 DA - 2021/01/18 DO - 10.1038/s41588-020-00763-1 UR - https://doi.org/10.1038/s41588-020-00763-1 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.