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Xueya Zhou, Pamela Feliciano, Chang Shu, Tianyun Wang, Irina Astrovskaya, Jacob B. Hall, Joseph U. Obiajulu, Jessica R. Wright, Shwetha Canchi Murali, Simon Xu and 412 more
Despite the known heritable nature of autism spectrum disorder (ASD), studies have primarily identified risk genes with de novo variants (DNVs). To capture the full spectrum of ASD genetic risk, we performed a two-stage analysis of rare de novo and inherited coding variants in 42,607 ASD cases, including 35,130 new cases recruited online by SPARK. In the first stage, we analyzed 19,843 cases with one or both biological parents and found that known ASD or neurodevelopmental disorder (NDD) risk genes explain nearly 70% of the genetic burden conferred by DNVs. In contrast, less than 20% of genetic risk conferred by rare inherited loss-of-function (LoF) variants are explained by known ASD/NDD genes. We selected 404 genes based on the first stage of analysis and performed a meta-analysis with an additional 22,764 cases and 236,000 population controls. We identified 60 genes with exome-wide significance (p < 2.5e-6), including five new risk genes ( NAV3, ITSN1, MARK2, SCAF1 , and HNRNPUL2) . The association of NAV3 with ASD risk is entirely driven by rare inherited LoFs variants, with an average relative risk of 4, consistent with moderate effect. ASD individuals with LoF variants in the four moderate risk genes (NAV3, ITSN1, SCAF1, and HNRNPUL2 , n = 95) have less cognitive impairment compared to 129 ASD individuals with LoF variants in well-established, highly penetrant ASD risk genes ( CHD8, SCN2A, ADNP, FOXP1, SHANK3) (59% vs. 88%, p= 1.9e-06). These findings will guide future gene discovery efforts and suggest that much larger numbers of ASD cases and controls are needed to identify additional genes that confer moderate risk of ASD through rare, inherited variants.
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Zhou, X., Feliciano, P., Shu, C., Wang, T., Astrovskaya, I., Hall, J. B., Obiajulu, J. U., Wright, J. R., Murali, S. C., Xu, S., Brueggeman, L., Thomas, T., Marchenko, O., Fleisch, C., Barns, S. D., Snyder, L. G., Han, B., Chang, T. S., Turner, T. N., … Chung, W. K. (2022). Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes. Nature Genetics, 54(9), 1305–1319. https://doi.org/10.1038/s41588-022-01148-2
Zhou, Xueya, et al. "Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes." Nature Genetics, vol. 54, no. 9, 2022, pp. 1305–1319, https://doi.org/10.1038/s41588-022-01148-2.
Zhou, Xueya, Pamela Feliciano, Chang Shu, Tianyun Wang, Irina Astrovskaya, Jacob B. Hall, Joseph U. Obiajulu, et al. "Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes." Nature Genetics 54, no. 9 (2022): 1305–1319. https://doi.org/10.1038/s41588-022-01148-2.
Zhou X., Feliciano P., Shu C. [и др.] Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes // Nature Genetics. — 2022. — Vol. 54, № 9. — P. 1305–1319. — URL: https://doi.org/10.1038/s41588-022-01148-2
@article{zhou2022integrating,
title = {{Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes}},
author = {Xueya Zhou and Pamela Feliciano and Chang Shu and Tianyun Wang and Irina Astrovskaya and Jacob B. Hall and Joseph U. Obiajulu and Jessica R. Wright and Shwetha Canchi Murali and Simon Xu and Leo Brueggeman and Taylor Thomas and Olena Marchenko and Christopher Fleisch and Sarah D. Barns and LeeAnne Green Snyder and Bing Han and Timothy S. Chang and Tychele N. Turner and William T. Harvey and Andrew Nishida and Brian J. O’Roak and Daniel H. Geschwind and Adrienne L. Adams and Alpha Amatya and Alicia Andrus and Asif Bashar and Anna F. Berman and Alison Brown and Alexies Camba and Amanda C. Gulsrud and Anthony D. Krentz and Amanda D. Shocklee and Amy Esler and Alex Lash and Anne Fanta and Ali S. Fatemi and Angela M. Fish and Alexandra Goler and Antonio Gonzalez and Anibal Gutierrez and Antonio Y. Hardan and Amy Hess and Anna Hirshman and Alison Holbrook and Andrea J. Ace and Anthony J. Griswold and Angela J. Gruber and A Jarratt and Anna Jelinek and Alissa B. Jorgenson and Aline Olimpia Ramírez Juárez and Annes Kim and Alex Kitaygorodsky and Addie Luo and Angela L. Rachubinski and Allison Wainer and Amy M. Daniels and Anup Mankar and Andrew Mason and Alexandra Miceli and Anna L. Milliken and Amy Morales-Lara and Alexandra N. Stephens and Ai Nhu Nguyen and Amy Nicholson and Anna Marie Paolicelli and Alexander P. McKenzie and Abha R. Gupta and A Raven and Anna Rhea and Andrea Simon and Aubrie Soucy and Amy R. Swanson and Anthony Sziklay and Amber Tallbull and Angela Tesng and Audrey Ward and Allyson Zick and Brittani A. Hilscher and Brandi Bell and Barbara Enright and Beverly E. Robertson and Brenda Hauf and Bill Jensen and Brandon Lobisi and Brianna M. Vernoia and Brady Schwind and Bonnie VanMetre and Craig A. Erickson and Catherine A.W. Sullivan and Charles Albright and Claudine Anglo and Cate Buescher and Catherine C. Bradley and Claudia Campo-Soria and Cheryl Cohen and Costanza Colombi and Chris Diggins and Catherine A. Edmonson and Catherine E. Rice and Carrie Fassler and Catherine Gray and Chris Gunter and Corrie H. Walston and Cheryl Klaiman and Caroline Leonczyk and Christa Lese Martin and Catherine Lord and Cora M. Taylor and Caitlin McCarthy and Cesar Ochoa‐Lubinoff and Crissy Ortiz and Cynthia L. Pierre and Cordelia Robinson Rosenberg and Chris Rigby and Casey Roche and Clara Shrier and Christopher R. Smith and Candace Van Wade and Casey Lehman and Christopher Zaro and Cindy Zha and Dawn Bentley and Dahriana Correa and Dustin E. Sarver and Giancarla David and David G. Amaral and Dain Howes and Dalia Istephanous and Daniel Lee Coury and Deana Li and Danica L. Limon and Desi Limpoco and Diamond Phillips and Desiree Rambeck and Daniela Rojas and Diksha Srishyla and Danielle Stamps and Dennis Vasquez Montes and Daniel Cho and Dave Cho and Emily A. Fox and Ethan Bahl and Elizabeth Berry‐Kravis and Elizabeth Blank and Erin Bower and Elizabeth A. Brooks and Eric Courchesne and Emily F. Dillon and Erin Doyle and Erin Given and Ellen Grimes and Erica Jones and Eric J Fombonne and Elizabeth M. Kryszak and Ericka L. Wodka and Elena Lamarche and Erica Lampert and Eric M. Butter and Eirene O’Connor and Edith V. Ocampo and Elizabeth Orrick and Esmeralda Perez and Elizabeth K. Ruzzo and Emily R. Singer and Emily T. Matthews and Ernest V. Pedapati and Faris Fazal and Fiona K. Miller and Gabriella Aberbach and Gabriele K. Baraghoshi and Gabrielle F. Duhon and Gregory Hooks and Gregory J. Fischer and Gabriela Marzano and Gregory Schoonover and Gabriel S. Dichter and Gabrielle Tiede and Hannah Cottrell and Hannah E. Kaplan and Haidar Ghina and Hanna Hutter and Hope Koene and Hoa Lam Schneider and Holly Lechniak and Hai Li and Hadley Morotti and Hongjian Qi and Harper Richardson and Hana Zaydens and Haicang Zhang and Haoquan Zhao and Ivette Arriaga and Ivy Fei Tso and John Acampado and Jennifer A. Gerdts and Josh Beeson and Jennylyn Brown and Joaquin Comitre and Jeanette M Cordova and Jennifer Delaporte and Joseph F. Cubells and Jill F. Harris and Jared Gong and Jaclyn A. Gunderson and Jessica Hernandez and Jessyca A. Judge and Jane Jurayj and Kiely Law and Julie Manoharan and Jessie Montezuma and Jason Neely and Jéssica Orobio and Juhi Pandey and Joseph Piven and José Polanco and Jibrielle Polite and Jacob Rosewater and Jessica Scherr and James S. Sutcliffe and James T. McCracken and Jennifer Tjernagel and Jaimie Toroney and Jeremy M. Veenstra-VanderWeele and Jiayao Wang and Katie Ahlers and Kathryn A. Schweers and Kelli L. Baalman and Katie Beard and Kristen Callahan and Kendra Coleman and Kate D. Fitzgerald and Kate Dent and Katharine Diehl and Kelsey Gonring and Katherine G. Pawlowski and Kathy Hirst and Karen Pierce and Karla Murillo and Kailey Murray and Kerri P. Nowell and Kaela O’Brien and Katrina Pama and Kelli Real and Kaitlyn Singer and Kaitlin Smith and Kevin G. Stephenson and Katherine Tsai and Leonard Abbeduto and Lindsey A. Cartner and Landon Beeson and Laura Arnstein Carpenter and Lucas G. Casten and Leigh A. Coppola and Lisa Cordiero and Lindsey DeMarco and Lillian D. Pacheco and Lorena Ferreira Corzo and Lisa H. Shulman and Lauren Kasparson Walsh and Laurie L. Lesher and Lynette M. Herbert and Lisa M. Prock and Lacy Malloch and Lori Mann and Luke P. Grosvenor and Laura Simon and Latha Valluripalli Soorya and Lucy Wasserburg and Lisa C. Yeh and Lark Y. Huang-Storms and Michael Alessandri and Marc Popp and Melissa Baer and Anna Malia Beckwith and Myriam Casseus and Michelle Coughlin and Mary Hannah Currin and Michele Cutri and Malcolm D. Mallardi and Megan Catherine DuBois and Megan E. Dunlevy and Martin E. Butler and Margot Frayne and McLeod Frampton Gwynette and Mohammad Ghaziuddin and Monica Haley and Michelle Heyman and Margaret A. Hojlo and Michelle Jordy and Michael J. Morrier and Misia Kowanda and Melinda Koza and Marilyn Lopez and Megan McTaggart and Megan Norris and Melissa N. Hale and Molly O’Neil and Madison Printen and Madelyn Rayos and Mahfuza Sabiha and Mustafa Şahin and Marina Sarris and Mojeeb Shir and Matthew S. Siegel and Morgan Steele and Megan Sweeney and Maira Tafolla and Maria Valicenti-McDermott and Mary Verdi and Megan Y. Dennis and Nicolas Alvarez and Nicole Bardett and Natalie Berger and Norma Calderon and Nickelle Decius and Natalia González and Nina Harris and Noah Lawson and Natasha Lillie and Nathan Lo and Nancy Long and Nicole M. Russo‐Ponsaran and Natalie Madi and Nicole Amber McCoy and Natalie Nagpal and Nicki Rodriguez and Nicholas Russell and Neelay Shah and Nicole Takahashi and Nicole Targalia and Olivia Newman and Opal Ousley and Peter T Heydemann and Patricia Manning and Paul S. Carbone and Raphael Bernier and Rachel Gordon and Rebecca C. Shaffer and Robert D. Annett and Renee D. Clark and Roger J. Jou and Rebecca J. Landa and Rachel K. Earl and Robin A. Libove and Richard Marini and Ryan N. Doan and Robin P. Goin‐Kochel and Rishiraj Rana and Richard Remington and Roman Shikov and Robert T. Schultz and Shelley Aberle and Shelby Birdwell and Sarah Boland and Stephanie Booker and S. Carpenter and Sharmista Chintalapalli and Sarah Conyers and Sophia D’Ambrosi and Sara Eldred and Sunday M. Francis and Swami Ganesan and Susan Hepburn and Susannah Horner and Samantha Hunter and Stephanie J. Brewster and Soo J. Lee and Suma Jacob and Stanley Jean and So Hyun and Sydney Kramer and Sandra Friedman and Sarely Licona and Sandy Littlefield and Stephen M. Kanne and Sarah A. Mastel and Sheena Mathai and Sophia Melnyk and Sarah Michaels and Sarah S. Mohiuddin and Samiza Palmer and Samantha N. Plate and Shanping Qiu and Shelley Randall and Sophia Sandhu and Susan L. Santangelo and Swapnil Shah and Steven A. Skinner and Samantha Thompson and Sabrina White and Stormi Pulver White and Sabrina Xiao and Sidi Xu and Simon Xu and Tia Chen and Tunisia Greene and Theodore Ho and Teresa Ibanez and Tanner Koomar and Tiziano Pramparo and Tara M. Rutter and Tamim H. Shaikh and Thao Tran and Timothy W. Yu and Virginia Galbraith and Vahid Gazestani and Vincent J. Myers and Vaikunt Ranganathan and Vini Singh and W Curtis Weaver and Wenteng CaI and Wubin Chin and Wha S. Yang and Y. B. Choi and Zachary E. Warren and Jacob J. Michaelson and Natalia Volfovsky and Evan E. Eichler and Yufeng Shen and Wendy K. Chung},
journal = {Nature Genetics},
year = {2022},
volume = {54},
number = {9},
pages = {1305--1319},
doi = {10.1038/s41588-022-01148-2},
url = {https://doi.org/10.1038/s41588-022-01148-2}
}TY - JOUR AU - Zhou, Xueya AU - Feliciano, Pamela AU - Shu, Chang AU - Wang, Tianyun AU - Astrovskaya, Irina AU - Hall, Jacob B. AU - Obiajulu, Joseph U. AU - Wright, Jessica R. AU - Murali, Shwetha Canchi AU - Xu, Simon AU - Brueggeman, Leo AU - Thomas, Taylor AU - Marchenko, Olena AU - Fleisch, Christopher AU - Barns, Sarah D. AU - Snyder, LeeAnne Green AU - Han, Bing AU - Chang, Timothy S. AU - Turner, Tychele N. AU - Harvey, William T. AU - Nishida, Andrew AU - O’Roak, Brian J. AU - Geschwind, Daniel H. AU - Adams, Adrienne L. AU - Amatya, Alpha AU - Andrus, Alicia AU - Bashar, Asif AU - Berman, Anna F. AU - Brown, Alison AU - Camba, Alexies AU - Gulsrud, Amanda C. AU - Krentz, Anthony D. AU - Shocklee, Amanda D. AU - Esler, Amy AU - Lash, Alex AU - Fanta, Anne AU - Fatemi, Ali S. AU - Fish, Angela M. AU - Goler, Alexandra AU - Gonzalez, Antonio AU - Gutierrez, Anibal AU - Hardan, Antonio Y. AU - Hess, Amy AU - Hirshman, Anna AU - Holbrook, Alison AU - Ace, Andrea J. AU - Griswold, Anthony J. AU - Gruber, Angela J. AU - Jarratt, A AU - Jelinek, Anna AU - Jorgenson, Alissa B. AU - Juárez, Aline Olimpia Ramírez AU - Kim, Annes AU - Kitaygorodsky, Alex AU - Luo, Addie AU - Rachubinski, Angela L. AU - Wainer, Allison AU - Daniels, Amy M. AU - Mankar, Anup AU - Mason, Andrew AU - Miceli, Alexandra AU - Milliken, Anna L. AU - Morales-Lara, Amy AU - Stephens, Alexandra N. AU - Nguyen, Ai Nhu AU - Nicholson, Amy AU - Paolicelli, Anna Marie AU - McKenzie, Alexander P. AU - Gupta, Abha R. AU - Raven, A AU - Rhea, Anna AU - Simon, Andrea AU - Soucy, Aubrie AU - Swanson, Amy R. AU - Sziklay, Anthony AU - Tallbull, Amber AU - Tesng, Angela AU - Ward, Audrey AU - Zick, Allyson AU - Hilscher, Brittani A. AU - Bell, Brandi AU - Enright, Barbara AU - Robertson, Beverly E. AU - Hauf, Brenda AU - Jensen, Bill AU - Lobisi, Brandon AU - Vernoia, Brianna M. AU - Schwind, Brady AU - VanMetre, Bonnie AU - Erickson, Craig A. AU - Sullivan, Catherine A.W. AU - Albright, Charles AU - Anglo, Claudine AU - Buescher, Cate AU - Bradley, Catherine C. AU - Campo-Soria, Claudia AU - Cohen, Cheryl AU - Colombi, Costanza AU - Diggins, Chris AU - Edmonson, Catherine A. AU - Rice, Catherine E. AU - Fassler, Carrie AU - Gray, Catherine AU - Gunter, Chris AU - Walston, Corrie H. AU - Klaiman, Cheryl AU - Leonczyk, Caroline AU - Martin, Christa Lese AU - Lord, Catherine AU - Taylor, Cora M. AU - McCarthy, Caitlin AU - Ochoa‐Lubinoff, Cesar AU - Ortiz, Crissy AU - Pierre, Cynthia L. AU - Rosenberg, Cordelia Robinson AU - Rigby, Chris AU - Roche, Casey AU - Shrier, Clara AU - Smith, Christopher R. AU - Wade, Candace Van AU - Lehman, Casey AU - Zaro, Christopher AU - Zha, Cindy AU - Bentley, Dawn AU - Correa, Dahriana AU - Sarver, Dustin E. AU - David, Giancarla AU - Amaral, David G. AU - Howes, Dain AU - Istephanous, Dalia AU - Coury, Daniel Lee AU - Li, Deana AU - Limon, Danica L. AU - Limpoco, Desi AU - Phillips, Diamond AU - Rambeck, Desiree AU - Rojas, Daniela AU - Srishyla, Diksha AU - Stamps, Danielle AU - Montes, Dennis Vasquez AU - Cho, Daniel AU - Cho, Dave AU - Fox, Emily A. AU - Bahl, Ethan AU - Berry‐Kravis, Elizabeth AU - Blank, Elizabeth AU - Bower, Erin AU - Brooks, Elizabeth A. AU - Courchesne, Eric AU - Dillon, Emily F. AU - Doyle, Erin AU - Given, Erin AU - Grimes, Ellen AU - Jones, Erica AU - Fombonne, Eric J AU - Kryszak, Elizabeth M. AU - Wodka, Ericka L. AU - Lamarche, Elena AU - Lampert, Erica AU - Butter, Eric M. AU - O’Connor, Eirene AU - Ocampo, Edith V. AU - Orrick, Elizabeth AU - Perez, Esmeralda AU - Ruzzo, Elizabeth K. AU - Singer, Emily R. AU - Matthews, Emily T. AU - Pedapati, Ernest V. AU - Fazal, Faris AU - Miller, Fiona K. AU - Aberbach, Gabriella AU - Baraghoshi, Gabriele K. AU - Duhon, Gabrielle F. AU - Hooks, Gregory AU - Fischer, Gregory J. AU - Marzano, Gabriela AU - Schoonover, Gregory AU - Dichter, Gabriel S. AU - Tiede, Gabrielle AU - Cottrell, Hannah AU - Kaplan, Hannah E. AU - Ghina, Haidar AU - Hutter, Hanna AU - Koene, Hope AU - Schneider, Hoa Lam AU - Lechniak, Holly AU - Li, Hai AU - Morotti, Hadley AU - Qi, Hongjian AU - Richardson, Harper AU - Zaydens, Hana AU - Zhang, Haicang AU - Zhao, Haoquan AU - Arriaga, Ivette AU - Tso, Ivy Fei AU - Acampado, John AU - Gerdts, Jennifer A. AU - Beeson, Josh AU - Brown, Jennylyn AU - Comitre, Joaquin AU - Cordova, Jeanette M AU - Delaporte, Jennifer AU - Cubells, Joseph F. AU - Harris, Jill F. AU - Gong, Jared AU - Gunderson, Jaclyn A. AU - Hernandez, Jessica AU - Judge, Jessyca A. AU - Jurayj, Jane AU - Law, Kiely AU - Manoharan, Julie AU - Montezuma, Jessie AU - Neely, Jason AU - Orobio, Jéssica AU - Pandey, Juhi AU - Piven, Joseph AU - Polanco, José AU - Polite, Jibrielle AU - Rosewater, Jacob AU - Scherr, Jessica AU - Sutcliffe, James S. AU - McCracken, James T. AU - Tjernagel, Jennifer AU - Toroney, Jaimie AU - Veenstra-VanderWeele, Jeremy M. AU - Wang, Jiayao AU - Ahlers, Katie AU - Schweers, Kathryn A. AU - Baalman, Kelli L. AU - Beard, Katie AU - Callahan, Kristen AU - Coleman, Kendra AU - Fitzgerald, Kate D. AU - Dent, Kate AU - Diehl, Katharine AU - Gonring, Kelsey AU - Pawlowski, Katherine G. AU - Hirst, Kathy AU - Pierce, Karen AU - Murillo, Karla AU - Murray, Kailey AU - Nowell, Kerri P. AU - O’Brien, Kaela AU - Pama, Katrina AU - Real, Kelli AU - Singer, Kaitlyn AU - Smith, Kaitlin AU - Stephenson, Kevin G. AU - Tsai, Katherine AU - Abbeduto, Leonard AU - Cartner, Lindsey A. AU - Beeson, Landon AU - Carpenter, Laura Arnstein AU - Casten, Lucas G. AU - Coppola, Leigh A. AU - Cordiero, Lisa AU - DeMarco, Lindsey AU - Pacheco, Lillian D. AU - Corzo, Lorena Ferreira AU - Shulman, Lisa H. AU - Walsh, Lauren Kasparson AU - Lesher, Laurie L. AU - Herbert, Lynette M. AU - Prock, Lisa M. AU - Malloch, Lacy AU - Mann, Lori AU - Grosvenor, Luke P. AU - Simon, Laura AU - Soorya, Latha Valluripalli AU - Wasserburg, Lucy AU - Yeh, Lisa C. AU - Huang-Storms, Lark Y. AU - Alessandri, Michael AU - Popp, Marc AU - Baer, Melissa AU - Beckwith, Anna Malia AU - Casseus, Myriam AU - Coughlin, Michelle AU - Currin, Mary Hannah AU - Cutri, Michele AU - Mallardi, Malcolm D. AU - DuBois, Megan Catherine AU - Dunlevy, Megan E. AU - Butler, Martin E. AU - Frayne, Margot AU - Gwynette, McLeod Frampton AU - Ghaziuddin, Mohammad AU - Haley, Monica AU - Heyman, Michelle AU - Hojlo, Margaret A. AU - Jordy, Michelle AU - Morrier, Michael J. AU - Kowanda, Misia AU - Koza, Melinda AU - Lopez, Marilyn AU - McTaggart, Megan AU - Norris, Megan AU - Hale, Melissa N. AU - O’Neil, Molly AU - Printen, Madison AU - Rayos, Madelyn AU - Sabiha, Mahfuza AU - Şahin, Mustafa AU - Sarris, Marina AU - Shir, Mojeeb AU - Siegel, Matthew S. AU - Steele, Morgan AU - Sweeney, Megan AU - Tafolla, Maira AU - Valicenti-McDermott, Maria AU - Verdi, Mary AU - Dennis, Megan Y. AU - Alvarez, Nicolas AU - Bardett, Nicole AU - Berger, Natalie AU - Calderon, Norma AU - Decius, Nickelle AU - González, Natalia AU - Harris, Nina AU - Lawson, Noah AU - Lillie, Natasha AU - Lo, Nathan AU - Long, Nancy AU - Russo‐Ponsaran, Nicole M. AU - Madi, Natalie AU - McCoy, Nicole Amber AU - Nagpal, Natalie AU - Rodriguez, Nicki AU - Russell, Nicholas AU - Shah, Neelay AU - Takahashi, Nicole AU - Targalia, Nicole AU - Newman, Olivia AU - Ousley, Opal AU - Heydemann, Peter T AU - Manning, Patricia AU - Carbone, Paul S. AU - Bernier, Raphael AU - Gordon, Rachel AU - Shaffer, Rebecca C. AU - Annett, Robert D. AU - Clark, Renee D. AU - Jou, Roger J. AU - Landa, Rebecca J. AU - Earl, Rachel K. AU - Libove, Robin A. AU - Marini, Richard AU - Doan, Ryan N. AU - Goin‐Kochel, Robin P. AU - Rana, Rishiraj AU - Remington, Richard AU - Shikov, Roman AU - Schultz, Robert T. AU - Aberle, Shelley AU - Birdwell, Shelby AU - Boland, Sarah AU - Booker, Stephanie AU - Carpenter, S. AU - Chintalapalli, Sharmista AU - Conyers, Sarah AU - D’Ambrosi, Sophia AU - Eldred, Sara AU - Francis, Sunday M. AU - Ganesan, Swami AU - Hepburn, Susan AU - Horner, Susannah AU - Hunter, Samantha AU - Brewster, Stephanie J. AU - Lee, Soo J. AU - Jacob, Suma AU - Jean, Stanley AU - Hyun, So AU - Kramer, Sydney AU - Friedman, Sandra AU - Licona, Sarely AU - Littlefield, Sandy AU - Kanne, Stephen M. AU - Mastel, Sarah A. AU - Mathai, Sheena AU - Melnyk, Sophia AU - Michaels, Sarah AU - Mohiuddin, Sarah S. AU - Palmer, Samiza AU - Plate, Samantha N. AU - Qiu, Shanping AU - Randall, Shelley AU - Sandhu, Sophia AU - Santangelo, Susan L. AU - Shah, Swapnil AU - Skinner, Steven A. AU - Thompson, Samantha AU - White, Sabrina AU - White, Stormi Pulver AU - Xiao, Sabrina AU - Xu, Sidi AU - Xu, Simon AU - Chen, Tia AU - Greene, Tunisia AU - Ho, Theodore AU - Ibanez, Teresa AU - Koomar, Tanner AU - Pramparo, Tiziano AU - Rutter, Tara M. AU - Shaikh, Tamim H. AU - Tran, Thao AU - Yu, Timothy W. AU - Galbraith, Virginia AU - Gazestani, Vahid AU - Myers, Vincent J. AU - Ranganathan, Vaikunt AU - Singh, Vini AU - Weaver, W Curtis AU - CaI, Wenteng AU - Chin, Wubin AU - Yang, Wha S. AU - Choi, Y. B. AU - Warren, Zachary E. AU - Michaelson, Jacob J. AU - Volfovsky, Natalia AU - Eichler, Evan E. AU - Shen, Yufeng AU - Chung, Wendy K. TI - Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes JO - Nature Genetics VL - 54 IS - 9 SP - 1305 EP - 1319 PY - 2022 DA - 2022/08/18 DO - 10.1038/s41588-022-01148-2 UR - https://doi.org/10.1038/s41588-022-01148-2 ER -
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