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Joana Isidro, Vítor Borges, Miguel Pinto, Daniel Sobral, João Dourado Santos, Alexandra Nunes, Verónica Mixão, Rita Ferreira, Daniela Santos, Sílvia Duarte and 7 more
The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 2022. Here, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first genome sequences of the MPXV outbreak variant. We observed that this MPXV belongs to the West African clade and that the ongoing outbreak most likely has a single origin. Although 2022 MPXV clustered with 2018–2019 cases epidemiologically linked to an endemic country, it segregates in a highly divergent phylogenetic branch (~ 50SNPs), likely representing a recent evolutionary jump. This hypermutation signature suggests the potential action of host APOBEC in viral evolution. We also detected ongoing microevolution (e.g., SNPs, minor variants and gene loss) during the human-to-human outbreak transmission, highlighting potential targets of adaptation. This study sheds light on MPXV adaptive evolution and indicates that genome sequencing might provide resolution to track the spread and transmission of this presumably slow-evolving dsDNA virus.
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Isidro, J., Borges, V., Pinto, M., Sobral, D., Santos, J. D., Nunes, A., Mixão, V., Ferreira, R., Santos, D., Duarte, S., Vieira, L., Borrego, M. J., Núncio, M. S., Carvalho, I. L. D., Pelerito, A., Cordeiro, R., & Gomes, J. P. (2022). Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus. Nature Medicine, 28(8), 1569–1572. https://doi.org/10.1038/s41591-022-01907-y
Isidro, Joana, et al. "Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus." Nature Medicine, vol. 28, no. 8, 2022, pp. 1569–1572, https://doi.org/10.1038/s41591-022-01907-y.
Isidro, Joana, Vítor Borges, Miguel Pinto, Daniel Sobral, João Dourado Santos, Alexandra Nunes, Verónica Mixão, et al. "Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus." Nature Medicine 28, no. 8 (2022): 1569–1572. https://doi.org/10.1038/s41591-022-01907-y.
Isidro J., Borges V., Pinto M. [и др.] Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus // Nature Medicine. — 2022. — Vol. 28, № 8. — P. 1569–1572. — URL: https://doi.org/10.1038/s41591-022-01907-y
@article{isidro2022phylogenomic,
title = {{Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus}},
author = {Joana Isidro and Vítor Borges and Miguel Pinto and Daniel Sobral and João Dourado Santos and Alexandra Nunes and Verónica Mixão and Rita Ferreira and Daniela Santos and Sílvia Duarte and Luı́s Vieira and Maria José Borrego and Maria Sofia Núncio and Isabel Lopes de Carvalho and Ana Pelerito and Rita Cordeiro and João Paulo Gomes},
journal = {Nature Medicine},
year = {2022},
volume = {28},
number = {8},
pages = {1569--1572},
doi = {10.1038/s41591-022-01907-y},
url = {https://doi.org/10.1038/s41591-022-01907-y}
}TY - JOUR AU - Isidro, Joana AU - Borges, Vítor AU - Pinto, Miguel AU - Sobral, Daniel AU - Santos, João Dourado AU - Nunes, Alexandra AU - Mixão, Verónica AU - Ferreira, Rita AU - Santos, Daniela AU - Duarte, Sílvia AU - Vieira, Luı́s AU - Borrego, Maria José AU - Núncio, Maria Sofia AU - Carvalho, Isabel Lopes de AU - Pelerito, Ana AU - Cordeiro, Rita AU - Gomes, João Paulo TI - Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus JO - Nature Medicine VL - 28 IS - 8 SP - 1569 EP - 1572 PY - 2022 DA - 2022/06/24 DO - 10.1038/s41591-022-01907-y UR - https://doi.org/10.1038/s41591-022-01907-y ER -
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