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Justine Y. Hansen, Golia Shafiei, Ross D. Markello, Kelly A. Smart, Sylvia M. L. Cox, Martin Nørgaard, Vincent Beliveau, Yanjun Wu, Jean‐Dominique Gallezot, Étienne Aumont and 32 more
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
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Hansen, J. Y., Shafiei, G., Markello, R. D., Smart, K. A., Cox, S. M. L., Nørgaard, M., Beliveau, V., Wu, Y., Gallezot, J., Aumont, É., Servaes, S., Scala, S. G., DuBois, J. M., Wainstein, G., Bezgin, G., Funck, T., Schmitz, T. W., Spreng, R. N., Galovic, M., … Mišić, B. (2022). Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. Nature Neuroscience, 25(11), 1569–1581. https://doi.org/10.1038/s41593-022-01186-3
Hansen, Justine Y., et al. "Mapping neurotransmitter systems to the structural and functional organization of the human neocortex." Nature Neuroscience, vol. 25, no. 11, 2022, pp. 1569–1581, https://doi.org/10.1038/s41593-022-01186-3.
Hansen, Justine Y., Golia Shafiei, Ross D. Markello, Kelly A. Smart, Sylvia M. L. Cox, Martin Nørgaard, Vincent Beliveau, et al. "Mapping neurotransmitter systems to the structural and functional organization of the human neocortex." Nature Neuroscience 25, no. 11 (2022): 1569–1581. https://doi.org/10.1038/s41593-022-01186-3.
Hansen J. Y., Shafiei G., Markello R. D. [и др.] Mapping neurotransmitter systems to the structural and functional organization of the human neocortex // Nature Neuroscience. — 2022. — Vol. 25, № 11. — P. 1569–1581. — URL: https://doi.org/10.1038/s41593-022-01186-3
@article{hansen2022mapping,
title = {{Mapping neurotransmitter systems to the structural and functional organization of the human neocortex}},
author = {Justine Y. Hansen and Golia Shafiei and Ross D. Markello and Kelly A. Smart and Sylvia M. L. Cox and Martin Nørgaard and Vincent Beliveau and Yanjun Wu and Jean‐Dominique Gallezot and Étienne Aumont and Stijn Servaes and Stephanie G. Scala and Jonathan M. DuBois and Gabriel Wainstein and Gleb Bezgin and Thomas Funck and Taylor W. Schmitz and R. Nathan Spreng and Marian Galovic and Matthias J. Koepp and John Sidney Duncan and Jonathan Coles and Tim D. Fryer and Franklin I. Aigbirhio and Colm J. McGinnity and Alexander Hammers and Jean‐Paul Soucy and Sylvain Baillet and Synthia Guimond and Jarmo A. Hietala and Marc‐André Bédard and Marco Leyton and Eliane Kobayashi and Pedro Rosa‐Neto and Melanie Ganz and Gitte M. Knudsen and Nicola Palomero‐Gallagher and James M. Shine and Richard E. Carson and Lauri J. Tuominen and Alain Dagher and Bratislav Mišić},
journal = {Nature Neuroscience},
year = {2022},
volume = {25},
number = {11},
pages = {1569--1581},
doi = {10.1038/s41593-022-01186-3},
url = {https://doi.org/10.1038/s41593-022-01186-3}
}TY - JOUR AU - Hansen, Justine Y. AU - Shafiei, Golia AU - Markello, Ross D. AU - Smart, Kelly A. AU - Cox, Sylvia M. L. AU - Nørgaard, Martin AU - Beliveau, Vincent AU - Wu, Yanjun AU - Gallezot, Jean‐Dominique AU - Aumont, Étienne AU - Servaes, Stijn AU - Scala, Stephanie G. AU - DuBois, Jonathan M. AU - Wainstein, Gabriel AU - Bezgin, Gleb AU - Funck, Thomas AU - Schmitz, Taylor W. AU - Spreng, R. Nathan AU - Galovic, Marian AU - Koepp, Matthias J. AU - Duncan, John Sidney AU - Coles, Jonathan AU - Fryer, Tim D. AU - Aigbirhio, Franklin I. AU - McGinnity, Colm J. AU - Hammers, Alexander AU - Soucy, Jean‐Paul AU - Baillet, Sylvain AU - Guimond, Synthia AU - Hietala, Jarmo A. AU - Bédard, Marc‐André AU - Leyton, Marco AU - Kobayashi, Eliane AU - Rosa‐Neto, Pedro AU - Ganz, Melanie AU - Knudsen, Gitte M. AU - Palomero‐Gallagher, Nicola AU - Shine, James M. AU - Carson, Richard E. AU - Tuominen, Lauri J. AU - Dagher, Alain AU - Mišić, Bratislav TI - Mapping neurotransmitter systems to the structural and functional organization of the human neocortex JO - Nature Neuroscience VL - 25 IS - 11 SP - 1569 EP - 1581 PY - 2022 DA - 2022/10/27 DO - 10.1038/s41593-022-01186-3 UR - https://doi.org/10.1038/s41593-022-01186-3 ER -
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