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Hana Štorkánová, Sabína Oreská, Maja Špiritović, Barbora Heřmánková, Kristýna Bubová, Martin Komarc, Karel Pavelká, Jiří Vencovský, Jörg H. W. Distler, Ladislav Šenolt, Radim Bečvář, Michal Tomčík
Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.
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Štorkánová, H., Oreská, S., Špiritović, M., Heřmánková, B., Bubová, K., Komarc, M., Pavelká, K., Vencovský, J., Distler, J. H. W., Šenolt, L., Bečvář, R., & Tomčík, M. (2021). Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study. Scientific Reports, 11(1), 1. https://doi.org/10.1038/s41598-020-79139-8
Štorkánová, Hana, et al. "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study." Scientific Reports, vol. 11, no. 1, 2021, pp. 1, https://doi.org/10.1038/s41598-020-79139-8.
Štorkánová, Hana, Sabína Oreská, Maja Špiritović, Barbora Heřmánková, Kristýna Bubová, Martin Komarc, Karel Pavelká, et al. "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study." Scientific Reports 11, no. 1 (2021): 1. https://doi.org/10.1038/s41598-020-79139-8.
Štorkánová H., Oreská S., Špiritović M. [и др.] Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study // Scientific Reports. — 2021. — Vol. 11, № 1. — P. 1. — URL: https://doi.org/10.1038/s41598-020-79139-8
@article{storkanova2021plasma,
title = {{Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study}},
author = {Hana Štorkánová and Sabína Oreská and Maja Špiritović and Barbora Heřmánková and Kristýna Bubová and Martin Komarc and Karel Pavelká and Jiří Vencovský and Jörg H. W. Distler and Ladislav Šenolt and Radim Bečvář and Michal Tomčík},
journal = {Scientific Reports},
year = {2021},
volume = {11},
number = {1},
pages = {1},
doi = {10.1038/s41598-020-79139-8},
url = {https://doi.org/10.1038/s41598-020-79139-8}
}TY - JOUR AU - Štorkánová, Hana AU - Oreská, Sabína AU - Špiritović, Maja AU - Heřmánková, Barbora AU - Bubová, Kristýna AU - Komarc, Martin AU - Pavelká, Karel AU - Vencovský, Jiří AU - Distler, Jörg H. W. AU - Šenolt, Ladislav AU - Bečvář, Radim AU - Tomčík, Michal TI - Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study JO - Scientific Reports VL - 11 IS - 1 SP - 1 PY - 2021 DA - 2021/01/07 DO - 10.1038/s41598-020-79139-8 UR - https://doi.org/10.1038/s41598-020-79139-8 ER -
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