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Visar Berisha, Chelsea Krantsevich, P. Richard Hahn, Shira Hahn, Gautam Dasarathy, Pavan K. Turaga, Julie Liss
Digital health data are multimodal and high-dimensional. A patient's health state can be characterized by a multitude of signals including medical imaging, clinical variables, genome sequencing, conversations between clinicians and patients, and continuous signals from wearables, among others. This high volume, personalized data stream aggregated over patients' lives has spurred interest in developing new artificial intelligence (AI) models for higher-precision diagnosis, prognosis, and tracking. While the promise of these algorithms is undeniable, their dissemination and adoption have been slow, owing partially to unpredictable AI model performance once deployed in the real world. We posit that one of the rate-limiting factors in developing algorithms that generalize to real-world scenarios is the very attribute that makes the data exciting-their high-dimensional nature. This paper considers how the large number of features in vast digital health data can challenge the development of robust AI models-a phenomenon known as "the curse of dimensionality" in statistical learning theory. We provide an overview of the curse of dimensionality in the context of digital health, demonstrate how it can negatively impact out-of-sample performance, and highlight important considerations for researchers and algorithm designers.
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Berisha, V., Krantsevich, C., Hahn, P. R., Hahn, S., Dasarathy, G., Turaga, P. K., & Liss, J. (2021). Digital medicine and the curse of dimensionality. npj Digital Medicine, 4(1), 153. https://doi.org/10.1038/s41746-021-00521-5
Berisha, Visar, et al. "Digital medicine and the curse of dimensionality." npj Digital Medicine, vol. 4, no. 1, 2021, pp. 153, https://doi.org/10.1038/s41746-021-00521-5.
Berisha, Visar, Chelsea Krantsevich, P. Richard Hahn, Shira Hahn, Gautam Dasarathy, Pavan K. Turaga, and Julie Liss. "Digital medicine and the curse of dimensionality." npj Digital Medicine 4, no. 1 (2021): 153. https://doi.org/10.1038/s41746-021-00521-5.
Berisha V., Krantsevich C., Hahn P. R. [и др.] Digital medicine and the curse of dimensionality // npj Digital Medicine. — 2021. — Vol. 4, № 1. — P. 153. — URL: https://doi.org/10.1038/s41746-021-00521-5
@article{berisha2021digital,
title = {{Digital medicine and the curse of dimensionality}},
author = {Visar Berisha and Chelsea Krantsevich and P. Richard Hahn and Shira Hahn and Gautam Dasarathy and Pavan K. Turaga and Julie Liss},
journal = {npj Digital Medicine},
year = {2021},
volume = {4},
number = {1},
pages = {153},
doi = {10.1038/s41746-021-00521-5},
url = {https://doi.org/10.1038/s41746-021-00521-5}
}TY - JOUR AU - Berisha, Visar AU - Krantsevich, Chelsea AU - Hahn, P. Richard AU - Hahn, Shira AU - Dasarathy, Gautam AU - Turaga, Pavan K. AU - Liss, Julie TI - Digital medicine and the curse of dimensionality JO - npj Digital Medicine VL - 4 IS - 1 SP - 153 PY - 2021 DA - 2021/10/28 DO - 10.1038/s41746-021-00521-5 UR - https://doi.org/10.1038/s41746-021-00521-5 ER -
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