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Bo Han, Xiang‐Hong He, Yanqing Liu, Gu He, Cheng Yun Peng, Jun‐Long Li
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed enormously to the field of organic synthesis since the early 2000s. As asymmetric organocatalytic methods mature, they have extended beyond the academia and undergone scale-up for the production of chiral drugs, natural products, and enantiomerically enriched bioactive molecules. This review provides a comprehensive overview of the applications of asymmetric organocatalysis in medicinal chemistry. A general picture of asymmetric organocatalytic strategies in medicinal chemistry is firstly presented, and the specific applications of these strategies in pharmaceutical synthesis are systematically described, with a focus on the preparation of antiviral, anticancer, neuroprotective, cardiovascular, antibacterial, and antiparasitic agents, as well as several miscellaneous bioactive agents. The review concludes with a discussion of the challenges, limitations and future prospects for organocatalytic asymmetric synthesis of medicinally valuable compounds.
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Han, B., He, X., Liu, Y., He, G., Peng, C. Y., & Li, J. (2021). Asymmetric organocatalysis: an enabling technology for medicinal chemistry. Chemical Society Reviews, 50(3), 1522–1586. https://doi.org/10.1039/d0cs00196a
Han, Bo, et al. "Asymmetric organocatalysis: an enabling technology for medicinal chemistry." Chemical Society Reviews, vol. 50, no. 3, 2021, pp. 1522–1586, https://doi.org/10.1039/d0cs00196a.
Han, Bo, Xiang‐Hong He, Yanqing Liu, Gu He, Cheng Yun Peng, and Jun‐Long Li. "Asymmetric organocatalysis: an enabling technology for medicinal chemistry." Chemical Society Reviews 50, no. 3 (2021): 1522–1586. https://doi.org/10.1039/d0cs00196a.
Han B., He X., Liu Y. [и др.] Asymmetric organocatalysis: an enabling technology for medicinal chemistry // Chemical Society Reviews. — 2021. — Vol. 50, № 3. — P. 1522–1586. — URL: https://doi.org/10.1039/d0cs00196a
@article{han2021asymmetric,
title = {{Asymmetric organocatalysis: an enabling technology for medicinal chemistry}},
author = {Bo Han and Xiang‐Hong He and Yanqing Liu and Gu He and Cheng Yun Peng and Jun‐Long Li},
journal = {Chemical Society Reviews},
year = {2021},
volume = {50},
number = {3},
pages = {1522--1586},
doi = {10.1039/d0cs00196a},
url = {https://doi.org/10.1039/d0cs00196a}
}TY - JOUR AU - Han, Bo AU - He, Xiang‐Hong AU - Liu, Yanqing AU - He, Gu AU - Peng, Cheng Yun AU - Li, Jun‐Long TI - Asymmetric organocatalysis: an enabling technology for medicinal chemistry JO - Chemical Society Reviews VL - 50 IS - 3 SP - 1522 EP - 1586 PY - 2021 DA - 2021/01/01 DO - 10.1039/d0cs00196a UR - https://doi.org/10.1039/d0cs00196a ER -
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