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Bee‐Ha Gan, Josephine S. Gaynord, Sam M. Rowe, Tomáš Deingruber, David R. Spring
Bacterial infections caused by 'superbugs' are increasing globally, and conventional antibiotics are becoming less effective against these bacteria, such that we risk entering a post-antibiotic era. In recent years, antimicrobial peptides (AMPs) have gained significant attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. In this review, we discuss several facets of AMPs including their diversity, physicochemical properties, mechanisms of action, and effects of environmental factors on these features. This review outlines various chemical synthetic strategies that have been applied to develop novel AMPs, including chemical modifications of existing peptides, semi-synthesis, and computer-aided design. We will also highlight novel AMP structures, including hybrids, antimicrobial dendrimers and polypeptides, peptidomimetics, and AMP-drug conjugates and consider recent developments in their chemical synthesis.
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Gan, B., Gaynord, J. S., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021). The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions. Chemical Society Reviews, 50(13), 7820–7880. https://doi.org/10.1039/d0cs00729c
Gan, Bee‐Ha, et al. "The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions." Chemical Society Reviews, vol. 50, no. 13, 2021, pp. 7820–7880, https://doi.org/10.1039/d0cs00729c.
Gan, Bee‐Ha, Josephine S. Gaynord, Sam M. Rowe, Tomáš Deingruber, and David R. Spring. "The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions." Chemical Society Reviews 50, no. 13 (2021): 7820–7880. https://doi.org/10.1039/d0cs00729c.
Gan B., Gaynord J. S., Rowe S. M. [и др.] The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions // Chemical Society Reviews. — 2021. — Vol. 50, № 13. — P. 7820–7880. — URL: https://doi.org/10.1039/d0cs00729c
@article{gan2021multifaceted,
title = {{The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions}},
author = {Bee‐Ha Gan and Josephine S. Gaynord and Sam M. Rowe and Tomáš Deingruber and David R. Spring},
journal = {Chemical Society Reviews},
year = {2021},
volume = {50},
number = {13},
pages = {7820--7880},
doi = {10.1039/d0cs00729c},
url = {https://doi.org/10.1039/d0cs00729c}
}TY - JOUR AU - Gan, Bee‐Ha AU - Gaynord, Josephine S. AU - Rowe, Sam M. AU - Deingruber, Tomáš AU - Spring, David R. TI - The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions JO - Chemical Society Reviews VL - 50 IS - 13 SP - 7820 EP - 7880 PY - 2021 DA - 2021/01/01 DO - 10.1039/d0cs00729c UR - https://doi.org/10.1039/d0cs00729c ER -
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