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Wenyi Li, Frances Separovic, Neil Martin O’brien-simpson, John D. Wade
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacterial infections than cancer. New antimicrobial agents, both broad-spectrum and selective, that do not induce AMR are urgently required. Antimicrobial peptides (AMPs) are a novel class of alternatives that possess potent activity against a wide range of Gram-negative and positive bacteria with little or no capacity to induce AMR. This has stimulated substantial chemical development of novel peptide-based antibiotics possessing improved therapeutic index. This review summarises recent synthetic efforts and their impact on analogue design as well as their various applications in AMP development. It includes modifications that have been reported to enhance antimicrobial activity including lipidation, glycosylation and multimerization through to the broad application of novel bio-orthogonal chemistry, as well as perspectives on the direction of future research. The subject area is primarily the development of next-generation antimicrobial agents through selective, rational chemical modification of AMPs. The review further serves as a guide toward the most promising directions in this field to stimulate broad scientific attention, and will lead to new, effective and selective solutions for the several biomedical challenges to which antimicrobial peptidomimetics are being applied.
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Li, W., Separovic, F., O’brien-simpson, N. M., & Wade, J. D. (2021). Chemically modified and conjugated antimicrobial peptides against superbugs. Chemical Society Reviews, 50(8), 4932–4973. https://doi.org/10.1039/d0cs01026j
Li, Wenyi, et al. "Chemically modified and conjugated antimicrobial peptides against superbugs." Chemical Society Reviews, vol. 50, no. 8, 2021, pp. 4932–4973, https://doi.org/10.1039/d0cs01026j.
Li, Wenyi, Frances Separovic, Neil Martin O’brien-simpson, and John D. Wade. "Chemically modified and conjugated antimicrobial peptides against superbugs." Chemical Society Reviews 50, no. 8 (2021): 4932–4973. https://doi.org/10.1039/d0cs01026j.
Li W., Separovic F., O’brien-simpson N. M. [и др.] Chemically modified and conjugated antimicrobial peptides against superbugs // Chemical Society Reviews. — 2021. — Vol. 50, № 8. — P. 4932–4973. — URL: https://doi.org/10.1039/d0cs01026j
@article{li2021chemically,
title = {{Chemically modified and conjugated antimicrobial peptides against superbugs}},
author = {Wenyi Li and Frances Separovic and Neil Martin O’brien-simpson and John D. Wade},
journal = {Chemical Society Reviews},
year = {2021},
volume = {50},
number = {8},
pages = {4932--4973},
doi = {10.1039/d0cs01026j},
url = {https://doi.org/10.1039/d0cs01026j}
}TY - JOUR AU - Li, Wenyi AU - Separovic, Frances AU - O’brien-simpson, Neil Martin AU - Wade, John D. TI - Chemically modified and conjugated antimicrobial peptides against superbugs JO - Chemical Society Reviews VL - 50 IS - 8 SP - 4932 EP - 4973 PY - 2021 DA - 2021/01/01 DO - 10.1039/d0cs01026j UR - https://doi.org/10.1039/d0cs01026j ER -
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