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Liwang Shi, Jinqiu Zhang, Man Zhao, Shukun Tang, Cheng Xu, Wenyuan Zhang, Wenhua Li, Xiaoying Liu, Haisheng Peng, Qun Wang
The rapid development of drug nanocarriers has benefited from the surface hydrophilic polymers of particles, which has improved the pharmacokinetics of the drugs. Polyethylene glycol (PEG) is a kind of polymeric material with unique hydrophilicity and electrical neutrality. PEG coating is a crucial factor to improve the biophysical and chemical properties of nanoparticles and is widely studied. Protein adherence and macrophage removal are effectively relieved due to the existence of PEG on the particles. This review discusses the PEGylation methods of nanoparticles and related techniques that have been used to detect the PEG coverage density and thickness on the surface of the nanoparticles in recent years. The molecular weight (MW) and coverage density of the PEG coating on the surface of nanoparticles are then described to explain the effects on the biophysical and chemical properties of nanoparticles.
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Shi, L., Zhang, J., Zhao, M., Tang, S., Xu, C., Zhang, W., Li, W., Liu, X., Peng, H., & Wang, Q. (2021). Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale, 13(24), 10748–10764. https://doi.org/10.1039/d1nr02065j
Shi, Liwang, et al. "Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery." Nanoscale, vol. 13, no. 24, 2021, pp. 10748–10764, https://doi.org/10.1039/d1nr02065j.
Shi, Liwang, Jinqiu Zhang, Man Zhao, Shukun Tang, Cheng Xu, Wenyuan Zhang, Wenhua Li, Xiaoying Liu, Haisheng Peng, and Qun Wang. "Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery." Nanoscale 13, no. 24 (2021): 10748–10764. https://doi.org/10.1039/d1nr02065j.
Shi L., Zhang J., Zhao M. [и др.] Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery // Nanoscale. — 2021. — Vol. 13, № 24. — P. 10748–10764. — URL: https://doi.org/10.1039/d1nr02065j
@article{shi2021effects,
title = {{Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery}},
author = {Liwang Shi and Jinqiu Zhang and Man Zhao and Shukun Tang and Cheng Xu and Wenyuan Zhang and Wenhua Li and Xiaoying Liu and Haisheng Peng and Qun Wang},
journal = {Nanoscale},
year = {2021},
volume = {13},
number = {24},
pages = {10748--10764},
doi = {10.1039/d1nr02065j},
url = {https://doi.org/10.1039/d1nr02065j}
}TY - JOUR AU - Shi, Liwang AU - Zhang, Jinqiu AU - Zhao, Man AU - Tang, Shukun AU - Xu, Cheng AU - Zhang, Wenyuan AU - Li, Wenhua AU - Liu, Xiaoying AU - Peng, Haisheng AU - Wang, Qun TI - Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery JO - Nanoscale VL - 13 IS - 24 SP - 10748 EP - 10764 PY - 2021 DA - 2021/01/01 DO - 10.1039/d1nr02065j UR - https://doi.org/10.1039/d1nr02065j ER -
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