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Tanzeela Fazal, Bibi Nazia Murtaza, Mazloom Shah, Shahid Iqbal, Mujaddad-ur Rehman, Fadi T. Jaber, Ayed A. Dera, Nasser S. Awwad, Hala A. Ibrahium
Targeted delivery of drug molecules to diseased sites is a great challenge in pharmaceutical and biomedical sciences. Fabrication of drug delivery systems (DDS) to target and/or diagnose sick cells is an effective means to achieve good therapeutic results along with a minimal toxicological impact on healthy cells. Biopolymers are becoming an important class of materials owing to their biodegradability, good compatibility, non-toxicity, non-immunogenicity, and long blood circulation time and high drug loading ratio for both macros as well as micro-sized drug molecules. This review summarizes the recent trends in biopolymer-based DDS, forecasting their broad future clinical applications. Cellulose chitosan, starch, silk fibroins, collagen, albumin, gelatin, alginate, agar, proteins and peptides have shown potential applications in DDS. A range of synthetic techniques have been reported to design the DDS and are discussed in the current study which is being successfully employed in ocular, dental, transdermal and intranasal delivery systems. Different formulations of DDS are also overviewed in this review article along with synthesis techniques employed for designing the DDS. The possibility of these biopolymer applications points to a new route for creating unique DDS with enhanced therapeutic qualities for scaling up creative formulations up to the clinical level.
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Fazal, T., Murtaza, B. N., Shah, M., Iqbal, S., Rehman, M.-U., Jaber, F. T., Dera, A. A., Awwad, N. S., & Ibrahium, H. A. (2023). Recent developments in natural biopolymer based drug delivery systems. RSC Advances, 13(33), 23087–23121. https://doi.org/10.1039/d3ra03369d
Fazal, Tanzeela, et al. "Recent developments in natural biopolymer based drug delivery systems." RSC Advances, vol. 13, no. 33, 2023, pp. 23087–23121, https://doi.org/10.1039/d3ra03369d.
Fazal, Tanzeela, Bibi Nazia Murtaza, Mazloom Shah, Shahid Iqbal, Mujaddad-ur Rehman, Fadi T. Jaber, Ayed A. Dera, Nasser S. Awwad, and Hala A. Ibrahium. "Recent developments in natural biopolymer based drug delivery systems." RSC Advances 13, no. 33 (2023): 23087–23121. https://doi.org/10.1039/d3ra03369d.
Fazal T., Murtaza B. N., Shah M. [и др.] Recent developments in natural biopolymer based drug delivery systems // RSC Advances. — 2023. — Vol. 13, № 33. — P. 23087–23121. — URL: https://doi.org/10.1039/d3ra03369d
@article{fazal2023recent,
title = {{Recent developments in natural biopolymer based drug delivery systems}},
author = {Tanzeela Fazal and Bibi Nazia Murtaza and Mazloom Shah and Shahid Iqbal and Mujaddad-ur Rehman and Fadi T. Jaber and Ayed A. Dera and Nasser S. Awwad and Hala A. Ibrahium},
journal = {RSC Advances},
year = {2023},
volume = {13},
number = {33},
pages = {23087--23121},
doi = {10.1039/d3ra03369d},
url = {https://doi.org/10.1039/d3ra03369d}
}TY - JOUR AU - Fazal, Tanzeela AU - Murtaza, Bibi Nazia AU - Shah, Mazloom AU - Iqbal, Shahid AU - Rehman, Mujaddad-ur AU - Jaber, Fadi T. AU - Dera, Ayed A. AU - Awwad, Nasser S. AU - Ibrahium, Hala A. TI - Recent developments in natural biopolymer based drug delivery systems JO - RSC Advances VL - 13 IS - 33 SP - 23087 EP - 23121 PY - 2023 DA - 2023/01/01 DO - 10.1039/d3ra03369d UR - https://doi.org/10.1039/d3ra03369d ER -
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