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Robert Yuzen Chen, Ishita Mostafa, Matthew Charles Hibberd, Subhasish Das, Mustafa Mahfuz, Nurun Nahar Naila, M Munirul Islam, Sayeeda Huq, Md Ashraful Alam, Mahabub Uz Zaman and 9 more
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHODS: In this study, we provided a microbiota-directed complementary food prototype (MDCF-2) or a ready-to-use supplementary food (RUSF) to 123 slum-dwelling Bangladeshi children with moderate acute malnutrition between the ages of 12 months and 18 months. The supplementation was given twice daily for 3 months, followed by 1 month of monitoring. We obtained weight-for-length, weight-for-age, and length-for-age z scores and mid-upper-arm circumference values at baseline and every 2 weeks during the intervention period and at 4 months. We compared the rate of change of these related phenotypes between baseline and 3 months and between baseline and 4 months. We also measured levels of 4977 proteins in plasma and 209 bacterial taxa in fecal samples. RESULTS: A total of 118 children (59 in each study group) completed the intervention. The rates of change in the weight-for-length and weight-for-age z scores are consistent with a benefit of MDCF-2 on growth over the course of the study, including the 1-month follow-up. Receipt of MDCF-2 was linked to the magnitude of change in levels of 70 plasma proteins and of 21 associated bacterial taxa that were positively correlated with the weight-for-length z score (P<0.001 for comparisons of both protein and bacterial taxa). These proteins included mediators of bone growth and neurodevelopment. CONCLUSIONS: These findings provide support for MDCF-2 as a dietary supplement for young children with moderate acute malnutrition and provide insight into mechanisms by which this targeted manipulation of microbiota components may be linked to growth. (Supported by the Bill and Melinda Gates Foundation and the National Institutes of Health; ClinicalTrials.gov number, NCT04015999.).
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Chen, R. Y., Mostafa, I., Hibberd, M. C., Das, S., Mahfuz, M., Naila, N. N., Islam, M. M., Huq, S., Alam, M. A., Zaman, M. U., Raman, A. S., Webber, D. M., Zhou, C., Sundaresan, V. M., Ahsan, K., Meier, M. F., Barratt, M. J., Ahmed, T., & Gordon, J. I. (2021). A Microbiota-Directed Food Intervention for Undernourished Children. New England Journal of Medicine, 384(16), 1517–1528. https://doi.org/10.1056/nejmoa2023294
Chen, Robert Yuzen, et al. "A Microbiota-Directed Food Intervention for Undernourished Children." New England Journal of Medicine, vol. 384, no. 16, 2021, pp. 1517–1528, https://doi.org/10.1056/nejmoa2023294.
Chen, Robert Yuzen, Ishita Mostafa, Matthew Charles Hibberd, Subhasish Das, Mustafa Mahfuz, Nurun Nahar Naila, M Munirul Islam, et al. "A Microbiota-Directed Food Intervention for Undernourished Children." New England Journal of Medicine 384, no. 16 (2021): 1517–1528. https://doi.org/10.1056/nejmoa2023294.
Chen R. Y., Mostafa I., Hibberd M. C. [и др.] A Microbiota-Directed Food Intervention for Undernourished Children // New England Journal of Medicine. — 2021. — Vol. 384, № 16. — P. 1517–1528. — URL: https://doi.org/10.1056/nejmoa2023294
@article{chen2021microbiotadirected,
title = {{A Microbiota-Directed Food Intervention for Undernourished Children}},
author = {Robert Yuzen Chen and Ishita Mostafa and Matthew Charles Hibberd and Subhasish Das and Mustafa Mahfuz and Nurun Nahar Naila and M Munirul Islam and Sayeeda Huq and Md Ashraful Alam and Mahabub Uz Zaman and Arjun S. Raman and Daniel M. Webber and Cyrus Zhou and Vinaik Mootha Sundaresan and Kazi Ahsan and Martin F. Meier and Michael J. Barratt and Tahmeed Ahmed and Jeffrey I. Gordon},
journal = {New England Journal of Medicine},
year = {2021},
volume = {384},
number = {16},
pages = {1517--1528},
doi = {10.1056/nejmoa2023294},
url = {https://doi.org/10.1056/nejmoa2023294}
}TY - JOUR AU - Chen, Robert Yuzen AU - Mostafa, Ishita AU - Hibberd, Matthew Charles AU - Das, Subhasish AU - Mahfuz, Mustafa AU - Naila, Nurun Nahar AU - Islam, M Munirul AU - Huq, Sayeeda AU - Alam, Md Ashraful AU - Zaman, Mahabub Uz AU - Raman, Arjun S. AU - Webber, Daniel M. AU - Zhou, Cyrus AU - Sundaresan, Vinaik Mootha AU - Ahsan, Kazi AU - Meier, Martin F. AU - Barratt, Michael J. AU - Ahmed, Tahmeed AU - Gordon, Jeffrey I. TI - A Microbiota-Directed Food Intervention for Undernourished Children JO - New England Journal of Medicine VL - 384 IS - 16 SP - 1517 EP - 1528 PY - 2021 DA - 2021/04/07 DO - 10.1056/nejmoa2023294 UR - https://doi.org/10.1056/nejmoa2023294 ER -
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