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François Lamontagne, Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Ruxandra L Pinto, Daren Keith Heyland, Deborah J Cook, Marie‐Claude Battista, Andrew G. Day, Gordon Henry Guyatt and 40 more
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction. METHODS: In this randomized, placebo-controlled trial, we assigned adults who had been in the ICU for no longer than 24 hours, who had proven or suspected infection as the main diagnosis, and who were receiving a vasopressor to receive an infusion of either vitamin C (at a dose of 50 mg per kilogram of body weight) or matched placebo administered every 6 hours for up to 96 hours. The primary outcome was a composite of death or persistent organ dysfunction (defined by the use of vasopressors, invasive mechanical ventilation, or new renal-replacement therapy) on day 28. RESULTS: A total of 872 patients underwent randomization (435 to the vitamin C group and 437 to the control group). The primary outcome occurred in 191 of 429 patients (44.5%) in the vitamin C group and in 167 of 434 patients (38.5%) in the control group (risk ratio, 1.21; 95% confidence interval [CI], 1.04 to 1.40; P = 0.01). At 28 days, death had occurred in 152 of 429 patients (35.4%) in the vitamin C group and in 137 of 434 patients (31.6%) in the placebo group (risk ratio, 1.17; 95% CI, 0.98 to 1.40) and persistent organ dysfunction in 39 of 429 patients (9.1%) and 30 of 434 patients (6.9%), respectively (risk ratio, 1.30; 95% CI, 0.83 to 2.05). Findings were similar in the two groups regarding organ-dysfunction scores, biomarkers, 6-month survival, health-related quality of life, stage 3 acute kidney injury, and hypoglycemic episodes. In the vitamin C group, one patient had a severe hypoglycemic episode and another had a serious anaphylaxis event. CONCLUSIONS: In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. (Funded by the Lotte and John Hecht Memorial Foundation; LOVIT ClinicalTrials.gov number, NCT03680274.).
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Lamontagne, F., Masse, M.-H., Ménard, J., Sprague, S., Pinto, R. L., Heyland, D. K., Cook, D. J., Battista, M., Day, A. G., Guyatt, G. H., Kanji, S., Parke, R. L., McGuinness, S., Vijayaraghavan, B. K. T., Annane, D., Cohen, D., Arabi, Y. M., Bolduc, B., Marinoff, N., … Adhikari, N. K. J. (2022). Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. New England Journal of Medicine, 386(25), 2387–2398. https://doi.org/10.1056/nejmoa2200644
Lamontagne, François, et al. "Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit." New England Journal of Medicine, vol. 386, no. 25, 2022, pp. 2387–2398, https://doi.org/10.1056/nejmoa2200644.
Lamontagne, François, Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Ruxandra L Pinto, Daren Keith Heyland, Deborah J Cook, et al. "Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit." New England Journal of Medicine 386, no. 25 (2022): 2387–2398. https://doi.org/10.1056/nejmoa2200644.
Lamontagne F., Masse M.-H., Ménard J. [и др.] Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit // New England Journal of Medicine. — 2022. — Vol. 386, № 25. — P. 2387–2398. — URL: https://doi.org/10.1056/nejmoa2200644
@article{lamontagne2022intravenous,
title = {{Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit}},
author = {François Lamontagne and Marie-Hélène Masse and Julie Ménard and Sheila Sprague and Ruxandra L Pinto and Daren Keith Heyland and Deborah J Cook and Marie‐Claude Battista and Andrew G. Day and Gordon Henry Guyatt and Salmaan Kanji and Rachael L. Parke and Shay McGuinness and Bharath Kumar Tirupakuzhi Vijayaraghavan and Djillali Annane and Dian Cohen and Yaseen M. Arabi and Brigitte Bolduc and Nicole Marinoff and Bram N. Rochwerg and Tina Millen and Maureen O. Meade and Lori E. Hand and Irene Watpool and Rebecca Porteous and Paul Jeffrey Young and Frédérick D’Aragon and Emilie P. Belley‐Côté and Élaine Carbonneau and France J. Clarke and David M. Maslove and Miranda Hunt and Michaël Chassé and Martine Lebrasseur and François Lauzier and Sangeeta Mehta and Hector Quiroz-Martinez and Oleksa Gregory Rewa and Emmanuel Charbonney and ANDREW J. E. SEELY and Demetrios James Kutsogiannis and Rémi Leblanc and Armand Mekontso Dessap and Tina S. Mele and Alexis F. Turgeon and Gordon Wood and Sandeep S. Kohli and Jason Shahin and Paweł Twardowski and Neill K. J. Adhikari},
journal = {New England Journal of Medicine},
year = {2022},
volume = {386},
number = {25},
pages = {2387--2398},
doi = {10.1056/nejmoa2200644},
url = {https://doi.org/10.1056/nejmoa2200644}
}TY - JOUR AU - Lamontagne, François AU - Masse, Marie-Hélène AU - Ménard, Julie AU - Sprague, Sheila AU - Pinto, Ruxandra L AU - Heyland, Daren Keith AU - Cook, Deborah J AU - Battista, Marie‐Claude AU - Day, Andrew G. AU - Guyatt, Gordon Henry AU - Kanji, Salmaan AU - Parke, Rachael L. AU - McGuinness, Shay AU - Vijayaraghavan, Bharath Kumar Tirupakuzhi AU - Annane, Djillali AU - Cohen, Dian AU - Arabi, Yaseen M. AU - Bolduc, Brigitte AU - Marinoff, Nicole AU - Rochwerg, Bram N. AU - Millen, Tina AU - Meade, Maureen O. AU - Hand, Lori E. AU - Watpool, Irene AU - Porteous, Rebecca AU - Young, Paul Jeffrey AU - D’Aragon, Frédérick AU - Belley‐Côté, Emilie P. AU - Carbonneau, Élaine AU - Clarke, France J. AU - Maslove, David M. AU - Hunt, Miranda AU - Chassé, Michaël AU - Lebrasseur, Martine AU - Lauzier, François AU - Mehta, Sangeeta AU - Quiroz-Martinez, Hector AU - Rewa, Oleksa Gregory AU - Charbonney, Emmanuel AU - SEELY, ANDREW J. E. AU - Kutsogiannis, Demetrios James AU - Leblanc, Rémi AU - Dessap, Armand Mekontso AU - Mele, Tina S. AU - Turgeon, Alexis F. AU - Wood, Gordon AU - Kohli, Sandeep S. AU - Shahin, Jason AU - Twardowski, Paweł AU - Adhikari, Neill K. J. TI - Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit JO - New England Journal of Medicine VL - 386 IS - 25 SP - 2387 EP - 2398 PY - 2022 DA - 2022/06/15 DO - 10.1056/nejmoa2200644 UR - https://doi.org/10.1056/nejmoa2200644 ER -
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