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Raffaele Marfella, Francesco Prattichizzo, Celestino Sardu, Gianluca Fulgenzi, Laura Graciotti, Tatiana Spadoni, Nunzia D’Onofrio, Lucia Scisciola, Rosalba La Grotta, Chiara Frigé and 33 more
BACKGROUND: Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this risk extends to humans is lacking. METHODS: We conducted a prospective, multicenter, observational study involving patients who were undergoing carotid endarterectomy for asymptomatic carotid artery disease. The excised carotid plaque specimens were analyzed for the presence of MNPs with the use of pyrolysis-gas chromatography-mass spectrometry, stable isotope analysis, and electron microscopy. Inflammatory biomarkers were assessed with enzyme-linked immunosorbent assay and immunohistochemical assay. The primary end point was a composite of myocardial infarction, stroke, or death from any cause among patients who had evidence of MNPs in plaque as compared with patients with plaque that showed no evidence of MNPs. RESULTS: A total of 304 patients were enrolled in the study, and 257 completed a mean (±SD) follow-up of 33.7±6.9 months. Polyethylene was detected in carotid artery plaque of 150 patients (58.4%), with a mean level of 21.7±24.5 μg per milligram of plaque; 31 patients (12.1%) also had measurable amounts of polyvinyl chloride, with a mean level of 5.2±2.4 μg per milligram of plaque. Electron microscopy revealed visible, jagged-edged foreign particles among plaque macrophages and scattered in the external debris. Radiographic examination showed that some of these particles included chlorine. Patients in whom MNPs were detected within the atheroma were at higher risk for a primary end-point event than those in whom these substances were not detected (hazard ratio, 4.53; 95% confidence interval, 2.00 to 10.27; P<0.001). CONCLUSIONS: In this study, patients with carotid artery plaque in which MNPs were detected had a higher risk of a composite of myocardial infarction, stroke, or death from any cause at 34 months of follow-up than those in whom MNPs were not detected. (Funded by Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale and others; ClinicalTrials.gov number, NCT05900947.).
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Marfella, R., Prattichizzo, F., Sardu, C., Fulgenzi, G., Graciotti, L., Spadoni, T., D’Onofrio, N., Scisciola, L., Grotta, R. L., Frigé, C., Pellegrini, V., Municinò, M., Siniscalchi, M., Spinetti, F., Vigliotti, G., Vecchione, C., Carrizzo, A., Accarino, G., Squillante, A., … Paolisso, G. (2024). Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. New England Journal of Medicine, 390(10), 900–910. https://doi.org/10.1056/nejmoa2309822
Marfella, Raffaele, et al. "Microplastics and Nanoplastics in Atheromas and Cardiovascular Events." New England Journal of Medicine, vol. 390, no. 10, 2024, pp. 900–910, https://doi.org/10.1056/nejmoa2309822.
Marfella, Raffaele, Francesco Prattichizzo, Celestino Sardu, Gianluca Fulgenzi, Laura Graciotti, Tatiana Spadoni, Nunzia D’Onofrio, et al. "Microplastics and Nanoplastics in Atheromas and Cardiovascular Events." New England Journal of Medicine 390, no. 10 (2024): 900–910. https://doi.org/10.1056/nejmoa2309822.
Marfella R., Prattichizzo F., Sardu C. [и др.] Microplastics and Nanoplastics in Atheromas and Cardiovascular Events // New England Journal of Medicine. — 2024. — Vol. 390, № 10. — P. 900–910. — URL: https://doi.org/10.1056/nejmoa2309822
@article{marfella2024microplastics,
title = {{Microplastics and Nanoplastics in Atheromas and Cardiovascular Events}},
author = {Raffaele Marfella and Francesco Prattichizzo and Celestino Sardu and Gianluca Fulgenzi and Laura Graciotti and Tatiana Spadoni and Nunzia D’Onofrio and Lucia Scisciola and Rosalba La Grotta and Chiara Frigé and Valeria Pellegrini and Maurizio Municinò and Mario Siniscalchi and Fabio Spinetti and Gennaro Vigliotti and Carmine Vecchione and Albino Carrizzo and Giulio Accarino and Antonio Squillante and Giuseppe Spaziano and Davida Mirra and Renata Esposito and Simona Altieri and Giovanni Falco and Angelo Fenti and Simona Galoppo and Silvana Canzano and Ferdinando Carlo Sasso and Giulia Matacchione and Fabiola Olivieri and Franca Ferraraccio and Iacopo Panarese and Pasquale Paolisso and Emanuele Barbato and Carmine Lubritto and Maria Luisa Balestrieri and Ciro Mauro and Augusto Enrique Caballero and Sanjay Rajagopalan and Antonio Ceriello and Bruno D’Agostino and Pasquale Iovino and Giuseppe Paolisso},
journal = {New England Journal of Medicine},
year = {2024},
volume = {390},
number = {10},
pages = {900--910},
doi = {10.1056/nejmoa2309822},
url = {https://doi.org/10.1056/nejmoa2309822}
}TY - JOUR AU - Marfella, Raffaele AU - Prattichizzo, Francesco AU - Sardu, Celestino AU - Fulgenzi, Gianluca AU - Graciotti, Laura AU - Spadoni, Tatiana AU - D’Onofrio, Nunzia AU - Scisciola, Lucia AU - Grotta, Rosalba La AU - Frigé, Chiara AU - Pellegrini, Valeria AU - Municinò, Maurizio AU - Siniscalchi, Mario AU - Spinetti, Fabio AU - Vigliotti, Gennaro AU - Vecchione, Carmine AU - Carrizzo, Albino AU - Accarino, Giulio AU - Squillante, Antonio AU - Spaziano, Giuseppe AU - Mirra, Davida AU - Esposito, Renata AU - Altieri, Simona AU - Falco, Giovanni AU - Fenti, Angelo AU - Galoppo, Simona AU - Canzano, Silvana AU - Sasso, Ferdinando Carlo AU - Matacchione, Giulia AU - Olivieri, Fabiola AU - Ferraraccio, Franca AU - Panarese, Iacopo AU - Paolisso, Pasquale AU - Barbato, Emanuele AU - Lubritto, Carmine AU - Balestrieri, Maria Luisa AU - Mauro, Ciro AU - Caballero, Augusto Enrique AU - Rajagopalan, Sanjay AU - Ceriello, Antonio AU - D’Agostino, Bruno AU - Iovino, Pasquale AU - Paolisso, Giuseppe TI - Microplastics and Nanoplastics in Atheromas and Cardiovascular Events JO - New England Journal of Medicine VL - 390 IS - 10 SP - 900 EP - 910 PY - 2024 DA - 2024/03/06 DO - 10.1056/nejmoa2309822 UR - https://doi.org/10.1056/nejmoa2309822 ER -
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