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Jacob Eifer Møller, Thomas Engstrøm, Lisette Okkels Jensen, Hans Eiskjær, Norman Mangner, Amin Polzin, Paul Christian Schulze, Carsten Skurk, Peter Nordbeck, Peter Michael Clemmensen and 26 more
BACKGROUND: The effects of temporary mechanical circulatory support with a microaxial flow pump on mortality among patients with ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock remains unclear. METHODS: In an international, multicenter, randomized trial, we assigned patients with STEMI and cardiogenic shock to receive a microaxial flow pump (Impella CP) plus standard care or standard care alone. The primary end point was death from any cause at 180 days. A composite safety end point was severe bleeding, limb ischemia, hemolysis, device failure, or worsening aortic regurgitation. RESULTS: A total of 360 patients underwent randomization, of whom 355 were included in the final analysis (179 in the microaxial-flow-pump group and 176 in the standard-care group). The median age of the patients was 67 years, and 79.2% were men. Death from any cause occurred in 82 of 179 patients (45.8%) in the microaxial-flow-pump group and in 103 of 176 patients (58.5%) in the standard-care group (hazard ratio, 0.74; 95% confidence interval [CI], 0.55 to 0.99; P = 0.04). A composite safety end-point event occurred in 43 patients (24.0%) in the microaxial-flow-pump group and in 11 (6.2%) in the standard-care group (relative risk, 4.74; 95% CI, 2.36 to 9.55). Renal-replacement therapy was administered to 75 patients (41.9%) in the microaxial-flow-pump group and to 47 patients (26.7%) in the standard-care group (relative risk, 1.98; 95% CI, 1.27 to 3.09). CONCLUSIONS: The routine use of a microaxial flow pump with standard care in the treatment of patients with STEMI-related cardiogenic shock led to a lower risk of death from any cause at 180 days than standard care alone. The incidence of a composite of adverse events was higher with the use of the microaxial flow pump. (Funded by the Danish Heart Foundation and Abiomed; DanGer Shock ClinicalTrials.gov number, NCT01633502.).
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Møller, J. E., Engstrøm, T., Jensen, L. O., Eiskjær, H., Mangner, N., Polzin, A., Schulze, P. C., Skurk, C., Nordbeck, P., Clemmensen, P. M., Panoulas, V. F., Zimmer, S., Schäfer, A., Werner, N., Frydland, M. S., Holmvang, L., Kjærgaard, J., Sørensen, R., Lønborg, J., … Hassager, C. (2024). Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock. New England Journal of Medicine, 390(15), 1382–1393. https://doi.org/10.1056/nejmoa2312572
Møller, Jacob Eifer, et al. "Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock." New England Journal of Medicine, vol. 390, no. 15, 2024, pp. 1382–1393, https://doi.org/10.1056/nejmoa2312572.
Møller, Jacob Eifer, Thomas Engstrøm, Lisette Okkels Jensen, Hans Eiskjær, Norman Mangner, Amin Polzin, Paul Christian Schulze, et al. "Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock." New England Journal of Medicine 390, no. 15 (2024): 1382–1393. https://doi.org/10.1056/nejmoa2312572.
Møller J. E., Engstrøm T., Jensen L. O. [и др.] Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock // New England Journal of Medicine. — 2024. — Vol. 390, № 15. — P. 1382–1393. — URL: https://doi.org/10.1056/nejmoa2312572
@article{mller2024microaxial,
title = {{Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock}},
author = {Jacob Eifer Møller and Thomas Engstrøm and Lisette Okkels Jensen and Hans Eiskjær and Norman Mangner and Amin Polzin and Paul Christian Schulze and Carsten Skurk and Peter Nordbeck and Peter Michael Clemmensen and Vasileios F. Panoulas and Sebastian Zimmer and Andreas Schäfer and Nikos Werner and Martin Steen Frydland and Lene Holmvang and Jesper Kjærgaard and Rikke Sørensen and Jacob Lønborg and Matias Greve Lindholm and Nanna Louise Junker Udesen and Anders Junker and Henrik Schmidt and Christian Juhl Terkelsen and Steffen Christensen and Evald Høj Christiansen and Axel Hans-Peter Linke and Felix J. Woitek and Ralf Westenfeld and Sven Möbius‐Winkler and Kristian Wachtell and Hanne Berg Ravn and Jens Flensted Lassen and Søren Boesgaard and Oke Gerke and Christian Hassager},
journal = {New England Journal of Medicine},
year = {2024},
volume = {390},
number = {15},
pages = {1382--1393},
doi = {10.1056/nejmoa2312572},
url = {https://doi.org/10.1056/nejmoa2312572}
}TY - JOUR AU - Møller, Jacob Eifer AU - Engstrøm, Thomas AU - Jensen, Lisette Okkels AU - Eiskjær, Hans AU - Mangner, Norman AU - Polzin, Amin AU - Schulze, Paul Christian AU - Skurk, Carsten AU - Nordbeck, Peter AU - Clemmensen, Peter Michael AU - Panoulas, Vasileios F. AU - Zimmer, Sebastian AU - Schäfer, Andreas AU - Werner, Nikos AU - Frydland, Martin Steen AU - Holmvang, Lene AU - Kjærgaard, Jesper AU - Sørensen, Rikke AU - Lønborg, Jacob AU - Lindholm, Matias Greve AU - Udesen, Nanna Louise Junker AU - Junker, Anders AU - Schmidt, Henrik AU - Terkelsen, Christian Juhl AU - Christensen, Steffen AU - Christiansen, Evald Høj AU - Linke, Axel Hans-Peter AU - Woitek, Felix J. AU - Westenfeld, Ralf AU - Möbius‐Winkler, Sven AU - Wachtell, Kristian AU - Ravn, Hanne Berg AU - Lassen, Jens Flensted AU - Boesgaard, Søren AU - Gerke, Oke AU - Hassager, Christian TI - Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock JO - New England Journal of Medicine VL - 390 IS - 15 SP - 1382 EP - 1393 PY - 2024 DA - 2024/04/07 DO - 10.1056/nejmoa2312572 UR - https://doi.org/10.1056/nejmoa2312572 ER -
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