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Seoyun Yum, Minghao Li, Yan Fang, Zhijian J. Chen
The induction of type I interferons through the transcription factor interferon regulatory factor 3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation that drives immune responses against DNA viruses and tumors. However, STING activation can also trigger other downstream pathways such as nuclear factor κB (NF-κB) signaling and autophagy, and the roles of interferon (IFN)-independent functions of STING in infectious diseases or cancer are not well understood. Here, we generated a STING mouse strain with a mutation (S365A) that disrupts IRF3 binding and therefore type I interferon induction but not NF-κB activation or autophagy induction. We also generated STING mice with mutations that disrupt the recruitment of TANK-binding kinase 1 (TBK1), which is important for both IRF3 and NF-κB activation but not autophagy induction (L373A or ∆CTT, which lacks the C-terminal tail). The STING-S365A mutant mice, but not L373A or ∆CTT mice, were still resistant to herpes simplex virus 1 (HSV-1) infections and mounted an antitumor response after cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) treatment despite the absence of STING-induced interferons. These results demonstrate that STING can function independently of type I interferons and autophagy, and that TBK1 recruitment to STING is essential for antiviral and antitumor immunity.
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Yum, S., Li, M., Fang, Y., & Chen, Z. J. (2021). TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections. Proceedings of the National Academy of Sciences, 118(14). https://doi.org/10.1073/pnas.2100225118
Yum, Seoyun, et al. "TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections." Proceedings of the National Academy of Sciences, vol. 118, no. 14, 2021, https://doi.org/10.1073/pnas.2100225118.
Yum, Seoyun, Minghao Li, Yan Fang, and Zhijian J. Chen. "TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections." Proceedings of the National Academy of Sciences 118, no. 14 (2021). https://doi.org/10.1073/pnas.2100225118.
Yum S., Li M., Fang Y. [и др.] TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections // Proceedings of the National Academy of Sciences. — 2021. — Vol. 118, № 14. — URL: https://doi.org/10.1073/pnas.2100225118
@article{yum2021recruitment,
title = {{TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections}},
author = {Seoyun Yum and Minghao Li and Yan Fang and Zhijian J. Chen},
journal = {Proceedings of the National Academy of Sciences},
year = {2021},
volume = {118},
number = {14},
doi = {10.1073/pnas.2100225118},
url = {https://doi.org/10.1073/pnas.2100225118}
}TY - JOUR AU - Yum, Seoyun AU - Li, Minghao AU - Fang, Yan AU - Chen, Zhijian J. TI - TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections JO - Proceedings of the National Academy of Sciences VL - 118 IS - 14 PY - 2021 DA - 2021/03/30 DO - 10.1073/pnas.2100225118 UR - https://doi.org/10.1073/pnas.2100225118 ER -
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