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Yongwang Lin, Jiamin Chen, Xuedong Zhou, Yuqing Li
Dental caries is one of the most prevalent and costly biofilm-associated infectious diseases affecting most of the world’s population. In particular, dental caries is driven by dysbiosis of the dental biofilm adherent to the enamel surface. Specific types of acid-producing bacteria, especially Streptococcus mutans, colonize the dental surface and cause damage to the hard tooth structure in the presence of fermentable carbohydrates. Streptococcus mutans has been established as the major cariogenic pathogen responsible for human dental caries, with a high ability to form biofilms. The exopolysaccharide (EPS) matrix, mainly contributed by S. mutans, has been considered as a virulence determinant of cariogenic biofilm. As EPS is an important virulence factor, targeting EPS metabolism could be useful in preventing cariogenic biofilm formation. This review summarizes plausible strategies targeting S. mutans biofilms by degrading EPS structure, inhibiting EPS production, and disturbing the EPS metabolism-related gene expression and regulatory systems.
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Lin, Y., Chen, J., Zhou, X., & Li, Y. (2021). Inhibition ofStreptococcus mutansbiofilm formation by strategies targeting the metabolism of exopolysaccharides. Critical Reviews in Microbiology, 47(5), 667–677. https://doi.org/10.1080/1040841x.2021.1915959
Lin, Yongwang, et al. "Inhibition ofStreptococcus mutansbiofilm formation by strategies targeting the metabolism of exopolysaccharides." Critical Reviews in Microbiology, vol. 47, no. 5, 2021, pp. 667–677, https://doi.org/10.1080/1040841x.2021.1915959.
Lin, Yongwang, Jiamin Chen, Xuedong Zhou, and Yuqing Li. "Inhibition ofStreptococcus mutansbiofilm formation by strategies targeting the metabolism of exopolysaccharides." Critical Reviews in Microbiology 47, no. 5 (2021): 667–677. https://doi.org/10.1080/1040841x.2021.1915959.
Lin Y., Chen J., Zhou X. [и др.] Inhibition ofStreptococcus mutansbiofilm formation by strategies targeting the metabolism of exopolysaccharides // Critical Reviews in Microbiology. — 2021. — Vol. 47, № 5. — P. 667–677. — URL: https://doi.org/10.1080/1040841x.2021.1915959
@article{lin2021inhibition,
title = {{Inhibition ofStreptococcus mutansbiofilm formation by strategies targeting the metabolism of exopolysaccharides}},
author = {Yongwang Lin and Jiamin Chen and Xuedong Zhou and Yuqing Li},
journal = {Critical Reviews in Microbiology},
year = {2021},
volume = {47},
number = {5},
pages = {667--677},
doi = {10.1080/1040841x.2021.1915959},
url = {https://doi.org/10.1080/1040841x.2021.1915959}
}TY - JOUR AU - Lin, Yongwang AU - Chen, Jiamin AU - Zhou, Xuedong AU - Li, Yuqing TI - Inhibition ofStreptococcus mutansbiofilm formation by strategies targeting the metabolism of exopolysaccharides JO - Critical Reviews in Microbiology VL - 47 IS - 5 SP - 667 EP - 677 PY - 2021 DA - 2021/05/03 DO - 10.1080/1040841x.2021.1915959 UR - https://doi.org/10.1080/1040841x.2021.1915959 ER -
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