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Yue Su, Bolun Zhang, Ruowei Sun, Wenfang Liu, Qubo Zhu, Xun Zhang, Rongrong Wang, Chuanpin Chen
Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocular-related diseases.
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Su, Y., Zhang, B., Sun, R., Liu, W., Zhu, Q., Zhang, X., Wang, R., & Chen, C. (2021). PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application. Drug Delivery, 28(1), 1397–1418. https://doi.org/10.1080/10717544.2021.1938756
Su, Yue, et al. "PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application." Drug Delivery, vol. 28, no. 1, 2021, pp. 1397–1418, https://doi.org/10.1080/10717544.2021.1938756.
Su, Yue, Bolun Zhang, Ruowei Sun, Wenfang Liu, Qubo Zhu, Xun Zhang, Rongrong Wang, and Chuanpin Chen. "PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application." Drug Delivery 28, no. 1 (2021): 1397–1418. https://doi.org/10.1080/10717544.2021.1938756.
Su Y., Zhang B., Sun R. [и др.] PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application // Drug Delivery. — 2021. — Vol. 28, № 1. — P. 1397–1418. — URL: https://doi.org/10.1080/10717544.2021.1938756
@article{su2021plgabased,
title = {{PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application}},
author = {Yue Su and Bolun Zhang and Ruowei Sun and Wenfang Liu and Qubo Zhu and Xun Zhang and Rongrong Wang and Chuanpin Chen},
journal = {Drug Delivery},
year = {2021},
volume = {28},
number = {1},
pages = {1397--1418},
doi = {10.1080/10717544.2021.1938756},
url = {https://doi.org/10.1080/10717544.2021.1938756}
}TY - JOUR AU - Su, Yue AU - Zhang, Bolun AU - Sun, Ruowei AU - Liu, Wenfang AU - Zhu, Qubo AU - Zhang, Xun AU - Wang, Rongrong AU - Chen, Chuanpin TI - PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application JO - Drug Delivery VL - 28 IS - 1 SP - 1397 EP - 1418 PY - 2021 DA - 2021/01/01 DO - 10.1080/10717544.2021.1938756 UR - https://doi.org/10.1080/10717544.2021.1938756 ER -
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