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Qin Tan, Xiao Ma, Bing Yang, Ye Liu, Yibin Xie, Xijun Wang, Wei Yuan, Jie Ma
Intratumor microbiome shapes the immune system and influences the outcome of various tumors. Porphyromonas gingivalis (P. gingivalis), the keystone periodontal pathogen, is highly epidemically connected with pancreatic cancer (PC). However, its causative role and the underlining mechanism in promoting PC oncogenesis remain unclear. Here, we illustrated the landscape of intratumor microbiome and its bacterial correlation with oral cavity in PC patients, where P. gingivalis presented both in the oral cavity and tumor tissues. When exposed to P. gingivalis, tumor development was accelerated in orthotopic and subcutaneous PC mouse model, and the cancerous pancreas exhibited a neutrophils-dominated proinflammatory tumor microenvironment. Mechanistically, the intratumoral P. gingivalis promoted PC progression via elevating the secretion of neutrophilic chemokines and neutrophil elastase (NE). Collectively, our study disclosed the bacterial link between periodontitis and PC, and revealed a previously unrecognized mechanism of P. gingivalis in PC pathophysiology, hinting at therapeutic implications.
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Tan, Q., Ma, X., Yang, B., Liu, Y., Xie, Y., Wang, X., Yuan, W., & Ma, J. (2022). Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils. Gut Microbes, 14(1), 2073785. https://doi.org/10.1080/19490976.2022.2073785
Tan, Qin, et al. "Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils." Gut Microbes, vol. 14, no. 1, 2022, pp. 2073785, https://doi.org/10.1080/19490976.2022.2073785.
Tan, Qin, Xiao Ma, Bing Yang, Ye Liu, Yibin Xie, Xijun Wang, Wei Yuan, and Jie Ma. "Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils." Gut Microbes 14, no. 1 (2022): 2073785. https://doi.org/10.1080/19490976.2022.2073785.
Tan Q., Ma X., Yang B. [и др.] Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils // Gut Microbes. — 2022. — Vol. 14, № 1. — P. 2073785. — URL: https://doi.org/10.1080/19490976.2022.2073785
@article{tan2022periodontitis,
title = {{Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils}},
author = {Qin Tan and Xiao Ma and Bing Yang and Ye Liu and Yibin Xie and Xijun Wang and Wei Yuan and Jie Ma},
journal = {Gut Microbes},
year = {2022},
volume = {14},
number = {1},
pages = {2073785},
doi = {10.1080/19490976.2022.2073785},
url = {https://doi.org/10.1080/19490976.2022.2073785}
}TY - JOUR AU - Tan, Qin AU - Ma, Xiao AU - Yang, Bing AU - Liu, Ye AU - Xie, Yibin AU - Wang, Xijun AU - Yuan, Wei AU - Ma, Jie TI - Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils JO - Gut Microbes VL - 14 IS - 1 SP - 2073785 PY - 2022 DA - 2022/05/12 DO - 10.1080/19490976.2022.2073785 UR - https://doi.org/10.1080/19490976.2022.2073785 ER -
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