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Richard Lalor, Krystyna Cwiklinski, Nichola Eliza Davies Calvani, Amber Dorey, Siobhán Hamon, Jesús López Corrales, John P. Dalton, Carolina De Marco Veríssimo
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the most important neglected parasitic diseases of humans and animals. The ability of the parasites to infect and multiply in their intermediate snail hosts, and their adaptation to a wide variety of mammalian definitive hosts contribute to their high transmissibility and distribution. Within the mammalian host, the trauma caused by the immature flukes burrowing through the liver parenchyma is associated with most of the pathogenesis. Similarly, the feeding activity and the physical presence of large flukes in the bile ducts can lead to anemia, inflammation, obstruction and cholangitis. The high frequency of non-synonymous polymorphisms found in Fasciola spp. genes allows for adaptation and invasion of a broad range of hosts. This is also facilitated by parasite’s excretory-secretory (ES) molecules that mediate physiological changes that allows their establishment within the host. ES contains cathepsin peptidases that aid parasite invasion by degrading collagen and fibronectin. In the bile ducts, cathepsin-L is critical to hemoglobin digestion during feeding activities. Other molecules (peroxiredoxin, cathepsin-L and Kunitz-type inhibitor) stimulate a strong immune response polarized toward a Treg/Th2 phenotype that favors fluke’s survival. Helminth defense molecule, fatty acid binding proteins, Fasciola-specific glycans and miRNAs modulate host pro-inflammatory responses, while antioxidant scavenger enzymes work in an orchestrated way to deter host oxidant-mediated damage. Combining these strategies Fasciola spp. survive for decades within their mammalian host, where they reproduce and spread to become one of the most widespread zoonotic worm parasites in the world.
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Lalor, R., Cwiklinski, K., Calvani, N. E. D., Dorey, A., Hamon, S., Corrales, J. L., Dalton, J. P., & Veríssimo, C. D. M. (2021). Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis. Virulence, 12(1), 2839–2867. https://doi.org/10.1080/21505594.2021.1996520
Lalor, Richard, et al. "Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis." Virulence, vol. 12, no. 1, 2021, pp. 2839–2867, https://doi.org/10.1080/21505594.2021.1996520.
Lalor, Richard, Krystyna Cwiklinski, Nichola Eliza Davies Calvani, Amber Dorey, Siobhán Hamon, Jesús López Corrales, John P. Dalton, and Carolina De Marco Veríssimo. "Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis." Virulence 12, no. 1 (2021): 2839–2867. https://doi.org/10.1080/21505594.2021.1996520.
Lalor R., Cwiklinski K., Calvani N. E. D. [и др.] Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis // Virulence. — 2021. — Vol. 12, № 1. — P. 2839–2867. — URL: https://doi.org/10.1080/21505594.2021.1996520
@article{lalor2021pathogenicity,
title = {{Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis}},
author = {Richard Lalor and Krystyna Cwiklinski and Nichola Eliza Davies Calvani and Amber Dorey and Siobhán Hamon and Jesús López Corrales and John P. Dalton and Carolina De Marco Veríssimo},
journal = {Virulence},
year = {2021},
volume = {12},
number = {1},
pages = {2839--2867},
doi = {10.1080/21505594.2021.1996520},
url = {https://doi.org/10.1080/21505594.2021.1996520}
}TY - JOUR AU - Lalor, Richard AU - Cwiklinski, Krystyna AU - Calvani, Nichola Eliza Davies AU - Dorey, Amber AU - Hamon, Siobhán AU - Corrales, Jesús López AU - Dalton, John P. AU - Veríssimo, Carolina De Marco TI - Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis JO - Virulence VL - 12 IS - 1 SP - 2839 EP - 2867 PY - 2021 DA - 2021/10/26 DO - 10.1080/21505594.2021.1996520 UR - https://doi.org/10.1080/21505594.2021.1996520 ER -
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