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Jolanda van der Velden, Folkert Wouter Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R. Bezzina, Ilze Bot, Bianca J.J.M. Brundel, Lucie Carrier, Steven A. J. Chamuleau and 51 more
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies, all of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task, in particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and comorbidities. This difficulty might lead some individuals to question the value of animal research, citing the translational 'valley of death', which largely reflects the fact that studies in rodents are difficult to translate to humans. This is also influenced by the fact that new, human-derived in vitro models can recapitulate aspects of disease processes. However, it would be a mistake to think that animal models do not represent a vital step in the translational pathway as they do provide important pathophysiological insights into disease mechanisms particularly on an organ and systemic level. While stem cell-derived human models have the potential to become key in testing toxicity and effectiveness of new drugs, we need to be realistic, and carefully validate all new human-like disease models. In this position paper, we highlight recent advances in trying to reduce the number of animals for cardiovascular research ranging from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and state-of-the-art animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. We aim to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction, and refinement (3R) as a guiding concept.
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Velden, J. V. D., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B. J., Carrier, L., Chamuleau, S. A. J., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., A, T. E., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., … Thum, T. (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 118(15), 3016–3051. https://doi.org/10.1093/cvr/cvab370
Velden, Jolanda van der, et al. "Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart." Cardiovascular Research, vol. 118, no. 15, 2022, pp. 3016–3051, https://doi.org/10.1093/cvr/cvab370.
Velden, Jolanda van der, Folkert Wouter Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R. Bezzina, Ilze Bot, et al. "Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart." Cardiovascular Research 118, no. 15 (2022): 3016–3051. https://doi.org/10.1093/cvr/cvab370.
Velden J. V. D., Asselbergs F. W., Bakkers J. [и др.] Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart // Cardiovascular Research. — 2022. — Vol. 118, № 15. — P. 3016–3051. — URL: https://doi.org/10.1093/cvr/cvab370
@article{velden2022animal,
title = {{Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart}},
author = {Jolanda van der Velden and Folkert Wouter Asselbergs and Jeroen Bakkers and Sandor Batkai and Luc Bertrand and Connie R. Bezzina and Ilze Bot and Bianca J.J.M. Brundel and Lucie Carrier and Steven A. J. Chamuleau and Michele Ciccarelli and Dana Dawson and Sean M. Davidson and Andreas Dendorfer and Dirk J Duncker and Thomas Eschenhagen A and Larissa Fabritz and Ines Falcão-Pires and Péter Ferdinandy and Mauro Giacca and Henrique Girao and Can Gollmann-Tepeköylü and Mariann Gyöngyösi and Tomasz J Guzik and Nazha Hamdani and Stephane R B Heymans and Andres Hilfiker and Denise Hilfiker-Kleiner and Alfons G. Hoekstra and Jean‐Sébastien Hulot and Diederik W.D. Kuster and Linda Wilhelmina Van Laake and Sandrine Lecour and Tim Leiner and Wolfgang Albrecht Linke and Joost Lumens and Esther Lutgens and Rosalinda Madonna and Lars Mäegdefessel and Manuel Mayr and Peter van der Meer and R. C. Passier and Filippo Perbellini and Cinzia Perrino and Maurizio Pesce and Silvia Giuliana Priori and Carol Ann Remme and Bodo Rosenhahn B and Ulrich Schotten and Rainer Schulz and Karin R. Sipido and Joost P. G. Sluijter and Frank G. van Steenbeek and Sabine Steffens and Cesare M Terracciano and Carlo Gabriele Tocchetti and Patricia Vlasman and Kak Khee Yeung and Serena Zacchigna and Dayenne Zwaagman and Thomas Thum},
journal = {Cardiovascular Research},
year = {2022},
volume = {118},
number = {15},
pages = {3016--3051},
doi = {10.1093/cvr/cvab370},
url = {https://doi.org/10.1093/cvr/cvab370}
}TY - JOUR AU - Velden, Jolanda van der AU - Asselbergs, Folkert Wouter AU - Bakkers, Jeroen AU - Batkai, Sandor AU - Bertrand, Luc AU - Bezzina, Connie R. AU - Bot, Ilze AU - Brundel, Bianca J.J.M. AU - Carrier, Lucie AU - Chamuleau, Steven A. J. AU - Ciccarelli, Michele AU - Dawson, Dana AU - Davidson, Sean M. AU - Dendorfer, Andreas AU - Duncker, Dirk J AU - A, Thomas Eschenhagen AU - Fabritz, Larissa AU - Falcão-Pires, Ines AU - Ferdinandy, Péter AU - Giacca, Mauro AU - Girao, Henrique AU - Gollmann-Tepeköylü, Can AU - Gyöngyösi, Mariann AU - Guzik, Tomasz J AU - Hamdani, Nazha AU - Heymans, Stephane R B AU - Hilfiker, Andres AU - Hilfiker-Kleiner, Denise AU - Hoekstra, Alfons G. AU - Hulot, Jean‐Sébastien AU - Kuster, Diederik W.D. AU - Laake, Linda Wilhelmina Van AU - Lecour, Sandrine AU - Leiner, Tim AU - Linke, Wolfgang Albrecht AU - Lumens, Joost AU - Lutgens, Esther AU - Madonna, Rosalinda AU - Mäegdefessel, Lars AU - Mayr, Manuel AU - Meer, Peter van der AU - Passier, R. C. AU - Perbellini, Filippo AU - Perrino, Cinzia AU - Pesce, Maurizio AU - Priori, Silvia Giuliana AU - Remme, Carol Ann AU - B, Bodo Rosenhahn AU - Schotten, Ulrich AU - Schulz, Rainer AU - Sipido, Karin R. AU - Sluijter, Joost P. G. AU - Steenbeek, Frank G. van AU - Steffens, Sabine AU - Terracciano, Cesare M AU - Tocchetti, Carlo Gabriele AU - Vlasman, Patricia AU - Yeung, Kak Khee AU - Zacchigna, Serena AU - Zwaagman, Dayenne AU - Thum, Thomas TI - Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart JO - Cardiovascular Research VL - 118 IS - 15 SP - 3016 EP - 3051 PY - 2022 DA - 2022/01/05 DO - 10.1093/cvr/cvab370 UR - https://doi.org/10.1093/cvr/cvab370 ER -
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