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Kaela Navarro, Monika K Huss, Jennifer C Smith, Patrick Sharp, James O. Marx, Cholawat Pacharinsak
There is an art and science to performing mouse anesthesia, which is a significant component to animal research. Frequently, anesthesia is one vital step of many over the course of a research project spanning weeks, months, or beyond. It is critical to perform anesthesia according to the approved research protocol using appropriately handled and administered pharmaceutical-grade compounds whenever possible. Sufficient documentation of the anesthetic event and procedure should also be performed to meet the legal, ethical, and research reproducibility obligations. However, this regulatory and documentation process may lead to the use of a few possibly oversimplified anesthetic protocols used for mouse procedures and anesthesia. Although a frequently used anesthetic protocol may work perfectly for each mouse anesthetized, sometimes unexpected complications will arise, and quick adjustments to the anesthetic depth and support provided will be required. As an old saying goes, anesthesia is 99% boredom and 1% sheer terror. The purpose of this review article is to discuss the science of mouse anesthesia together with the art of applying these anesthetic techniques to provide readers with the knowledge needed for successful anesthetic procedures. The authors include experiences in mouse inhalant and injectable anesthesia, peri-anesthetic monitoring, specific procedures, and treating common complications. This article utilizes key points for easy access of important messages and authors' recommendation based on the authors' clinical experiences.
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Navarro, K., Huss, M. K., Smith, J. C., Sharp, P., Marx, J. O., & Pacharinsak, C. (2021). Mouse Anesthesia: The Art and Science. ILAR Journal, 62(1-2), 238–273. https://doi.org/10.1093/ilar/ilab016
Navarro, Kaela, et al. "Mouse Anesthesia: The Art and Science." ILAR Journal, vol. 62, no. 1-2, 2021, pp. 238–273, https://doi.org/10.1093/ilar/ilab016.
Navarro, Kaela, Monika K Huss, Jennifer C Smith, Patrick Sharp, James O. Marx, and Cholawat Pacharinsak. "Mouse Anesthesia: The Art and Science." ILAR Journal 62, no. 1-2 (2021): 238–273. https://doi.org/10.1093/ilar/ilab016.
Navarro K., Huss M. K., Smith J. C. [и др.] Mouse Anesthesia: The Art and Science // ILAR Journal. — 2021. — Vol. 62, № 1-2. — P. 238–273. — URL: https://doi.org/10.1093/ilar/ilab016
@article{navarro2021mouse,
title = {{Mouse Anesthesia: The Art and Science}},
author = {Kaela Navarro and Monika K Huss and Jennifer C Smith and Patrick Sharp and James O. Marx and Cholawat Pacharinsak},
journal = {ILAR Journal},
year = {2021},
volume = {62},
number = {1-2},
pages = {238--273},
doi = {10.1093/ilar/ilab016},
url = {https://doi.org/10.1093/ilar/ilab016}
}TY - JOUR AU - Navarro, Kaela AU - Huss, Monika K AU - Smith, Jennifer C AU - Sharp, Patrick AU - Marx, James O. AU - Pacharinsak, Cholawat TI - Mouse Anesthesia: The Art and Science JO - ILAR Journal VL - 62 IS - 1-2 SP - 238 EP - 273 PY - 2021 DA - 2021/01/01 DO - 10.1093/ilar/ilab016 UR - https://doi.org/10.1093/ilar/ilab016 ER -
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