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Marc E. Gillespie, Bijay Jassal, Ralf Stephan, Marija Orlic-Milacic, Karen Rothfels, Andrea Senff‐Ribeiro, Johannes Griss, Cristoffer Sevilla, Lisa R. Matthews, Chuqiao Gong and 25 more
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.
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Gillespie, M. E., Jassal, B., Stephan, R., Orlic-Milacic, M., Rothfels, K., Senff‐Ribeiro, A., Griss, J., Sevilla, C., Matthews, L. R., Gong, C., Deng, C., Varusai, T., Ragueneau, E., Haider, Y., May, B., Shamovsky, V., Weiser, J., Brunson, T., Sanati, N., … D’Eustachio, P. (2021). The reactome pathway knowledgebase 2022. Nucleic Acids Research, 50(D1), D687–D692. https://doi.org/10.1093/nar/gkab1028
Gillespie, Marc E., et al. "The reactome pathway knowledgebase 2022." Nucleic Acids Research, vol. 50, no. D1, 2021, pp. D687–D692, https://doi.org/10.1093/nar/gkab1028.
Gillespie, Marc E., Bijay Jassal, Ralf Stephan, Marija Orlic-Milacic, Karen Rothfels, Andrea Senff‐Ribeiro, Johannes Griss, et al. "The reactome pathway knowledgebase 2022." Nucleic Acids Research 50, no. D1 (2021): D687–D692. https://doi.org/10.1093/nar/gkab1028.
Gillespie M. E., Jassal B., Stephan R. [и др.] The reactome pathway knowledgebase 2022 // Nucleic Acids Research. — 2021. — Vol. 50, № D1. — P. D687–D692. — URL: https://doi.org/10.1093/nar/gkab1028
@article{gillespie2021reactome,
title = {{The reactome pathway knowledgebase 2022}},
author = {Marc E. Gillespie and Bijay Jassal and Ralf Stephan and Marija Orlic-Milacic and Karen Rothfels and Andrea Senff‐Ribeiro and Johannes Griss and Cristoffer Sevilla and Lisa R. Matthews and Chuqiao Gong and Chuan Deng and Thawfeek Varusai and Eliot Ragueneau and Yusra Haider and Bruce May and Veronica Shamovsky and Joel Weiser and Timothy Brunson and Nasim Sanati and Liam Beckman and Xiang Shao and Antonio Fabregat and Konstantinos Sidiropoulos and Julieth Murillo and Guilherme Viteri and Justin Cook and Solomon I. Shorser and Gary D. Bader and Emek Demir and Chris Sander and Robin Haw and Guanming Wu and Lincoln David Stein and Henning Hermjakob and Peter D’Eustachio},
journal = {Nucleic Acids Research},
year = {2021},
volume = {50},
number = {D1},
pages = {D687--D692},
doi = {10.1093/nar/gkab1028},
url = {https://doi.org/10.1093/nar/gkab1028}
}TY - JOUR AU - Gillespie, Marc E. AU - Jassal, Bijay AU - Stephan, Ralf AU - Orlic-Milacic, Marija AU - Rothfels, Karen AU - Senff‐Ribeiro, Andrea AU - Griss, Johannes AU - Sevilla, Cristoffer AU - Matthews, Lisa R. AU - Gong, Chuqiao AU - Deng, Chuan AU - Varusai, Thawfeek AU - Ragueneau, Eliot AU - Haider, Yusra AU - May, Bruce AU - Shamovsky, Veronica AU - Weiser, Joel AU - Brunson, Timothy AU - Sanati, Nasim AU - Beckman, Liam AU - Shao, Xiang AU - Fabregat, Antonio AU - Sidiropoulos, Konstantinos AU - Murillo, Julieth AU - Viteri, Guilherme AU - Cook, Justin AU - Shorser, Solomon I. AU - Bader, Gary D. AU - Demir, Emek AU - Sander, Chris AU - Haw, Robin AU - Wu, Guanming AU - Stein, Lincoln David AU - Hermjakob, Henning AU - D’Eustachio, Peter TI - The reactome pathway knowledgebase 2022 JO - Nucleic Acids Research VL - 50 IS - D1 SP - D687 EP - D692 PY - 2021 DA - 2021/10/13 DO - 10.1093/nar/gkab1028 UR - https://doi.org/10.1093/nar/gkab1028 ER -
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