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Kai Blin, Simon Shaw, Alexander Kloosterman, Zachary Charlop–Powers, Gilles P. van Wezel, Marnix H. Medema, Tilmann Weber
Many microorganisms produce natural products that form the basis of antimicrobials, antivirals, and other drugs. Genome mining is routinely used to complement screening-based workflows to discover novel natural products. Since 2011, the "antibiotics and secondary metabolite analysis shell-antiSMASH" (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free-to-use web server and as a standalone tool under an OSI-approved open-source license. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in bacteria and fungi. Here, we present the updated version 6 of antiSMASH. antiSMASH 6 increases the number of supported cluster types from 58 to 71, displays the modular structure of multi-modular BGCs, adds a new BGC comparison algorithm, allows for the integration of results from other prediction tools, and more effectively detects tailoring enzymes in RiPP clusters.
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Blin, K., Shaw, S., Kloosterman, A., Charlop–Powers, Z., Wezel, G. P. V., Medema, M. H., & Weber, T. (2021). antiSMASH 6.0: improving cluster detection and comparison capabilities. Nucleic Acids Research, 49(W1), W29–W35. https://doi.org/10.1093/nar/gkab335
Blin, Kai, et al. "antiSMASH 6.0: improving cluster detection and comparison capabilities." Nucleic Acids Research, vol. 49, no. W1, 2021, pp. W29–W35, https://doi.org/10.1093/nar/gkab335.
Blin, Kai, Simon Shaw, Alexander Kloosterman, Zachary Charlop–Powers, Gilles P. van Wezel, Marnix H. Medema, and Tilmann Weber. "antiSMASH 6.0: improving cluster detection and comparison capabilities." Nucleic Acids Research 49, no. W1 (2021): W29–W35. https://doi.org/10.1093/nar/gkab335.
Blin K., Shaw S., Kloosterman A. [и др.] antiSMASH 6.0: improving cluster detection and comparison capabilities // Nucleic Acids Research. — 2021. — Vol. 49, № W1. — P. W29–W35. — URL: https://doi.org/10.1093/nar/gkab335
@article{blin2021antismash,
title = {{antiSMASH 6.0: improving cluster detection and comparison capabilities}},
author = {Kai Blin and Simon Shaw and Alexander Kloosterman and Zachary Charlop–Powers and Gilles P. van Wezel and Marnix H. Medema and Tilmann Weber},
journal = {Nucleic Acids Research},
year = {2021},
volume = {49},
number = {W1},
pages = {W29--W35},
doi = {10.1093/nar/gkab335},
url = {https://doi.org/10.1093/nar/gkab335}
}TY - JOUR AU - Blin, Kai AU - Shaw, Simon AU - Kloosterman, Alexander AU - Charlop–Powers, Zachary AU - Wezel, Gilles P. van AU - Medema, Marnix H. AU - Weber, Tilmann TI - antiSMASH 6.0: improving cluster detection and comparison capabilities JO - Nucleic Acids Research VL - 49 IS - W1 SP - W29 EP - W35 PY - 2021 DA - 2021/04/19 DO - 10.1093/nar/gkab335 UR - https://doi.org/10.1093/nar/gkab335 ER -
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