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David N. Louis, Arie Perry, Pieter Wesseling, Daniel Jay Brat, Ian A. Cree, Dominique F. Figarella-Branger, Cynthia E Hawkins, Ho‐Keung Ng, Stefan Michael Pfister, Guido Reifenberger and 3 more
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors. Building on the 2016 updated fourth edition and the work of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy, the 2021 fifth edition introduces major changes that advance the role of molecular diagnostics in CNS tumor classification. At the same time, it remains wedded to other established approaches to tumor diagnosis such as histology and immunohistochemistry. In doing so, the fifth edition establishes some different approaches to both CNS tumor nomenclature and grading and it emphasizes the importance of integrated diagnoses and layered reports. New tumor types and subtypes are introduced, some based on novel diagnostic technologies such as DNA methylome profiling. The present review summarizes the major general changes in the 2021 fifth edition classification and the specific changes in each taxonomic category. It is hoped that this summary provides an overview to facilitate more in-depth exploration of the entire fifth edition of the WHO Classification of Tumors of the Central Nervous System.
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Louis, D. N., Perry, A., Wesseling, P., Brat, D. J., Cree, I. A., Figarella-Branger, D. F., Hawkins, C. E., Ng, H., Pfister, S. M., Reifenberger, G., Soffietti, R., Deimling, A. V., & Ellison, D. W. (2021). The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology, 23(8), 1231–1251. https://doi.org/10.1093/neuonc/noab106
Louis, David N., et al. "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary." Neuro-Oncology, vol. 23, no. 8, 2021, pp. 1231–1251, https://doi.org/10.1093/neuonc/noab106.
Louis, David N., Arie Perry, Pieter Wesseling, Daniel Jay Brat, Ian A. Cree, Dominique F. Figarella-Branger, Cynthia E Hawkins, et al. "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary." Neuro-Oncology 23, no. 8 (2021): 1231–1251. https://doi.org/10.1093/neuonc/noab106.
Louis D. N., Perry A., Wesseling P. [и др.] The 2021 WHO Classification of Tumors of the Central Nervous System: a summary // Neuro-Oncology. — 2021. — Vol. 23, № 8. — P. 1231–1251. — URL: https://doi.org/10.1093/neuonc/noab106
@article{louis2021classification,
title = {{The 2021 WHO Classification of Tumors of the Central Nervous System: a summary}},
author = {David N. Louis and Arie Perry and Pieter Wesseling and Daniel Jay Brat and Ian A. Cree and Dominique F. Figarella-Branger and Cynthia E Hawkins and Ho‐Keung Ng and Stefan Michael Pfister and Guido Reifenberger and Riccardo Soffietti and Andreas von Deimling and David W. Ellison},
journal = {Neuro-Oncology},
year = {2021},
volume = {23},
number = {8},
pages = {1231--1251},
doi = {10.1093/neuonc/noab106},
url = {https://doi.org/10.1093/neuonc/noab106}
}TY - JOUR AU - Louis, David N. AU - Perry, Arie AU - Wesseling, Pieter AU - Brat, Daniel Jay AU - Cree, Ian A. AU - Figarella-Branger, Dominique F. AU - Hawkins, Cynthia E AU - Ng, Ho‐Keung AU - Pfister, Stefan Michael AU - Reifenberger, Guido AU - Soffietti, Riccardo AU - Deimling, Andreas von AU - Ellison, David W. TI - The 2021 WHO Classification of Tumors of the Central Nervous System: a summary JO - Neuro-Oncology VL - 23 IS - 8 SP - 1231 EP - 1251 PY - 2021 DA - 2021/05/03 DO - 10.1093/neuonc/noab106 UR - https://doi.org/10.1093/neuonc/noab106 ER -
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