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Přemysl Mladěnka, Kateřina Macáková, Lenka Kujovská Krčmová, Lenka Javorská, Kristýna Mrštná, Alejandro Carazo, Michele Protti, Fernando Remião, Lucie Nováková, the OEMONOM researchers and collaborators
Vitamin K is traditionally connected with blood coagulation, since it is needed for the posttranslational modification of 7 proteins involved in this cascade. However, it is also involved in the maturation of another 11 or 12 proteins that play different roles, encompassing in particular the modulation of the calcification of connective tissues. Since this process is physiologically needed in bones, but is pathological in arteries, a great deal of research has been devoted to finding a possible link between vitamin K and the prevention of osteoporosis and cardiovascular diseases. Unfortunately, the current knowledge does not allow us to make a decisive conclusion about such a link. One possible explanation for this is the diversity of the biological activity of vitamin K, which is not a single compound but a general term covering natural plant and animal forms of vitamin K (K1 and K2) as well as their synthetic congeners (K3 and K4). Vitamin K1 (phylloquinone) is found in several vegetables. Menaquinones (MK4-MK13, a series of compounds known as vitamin K2) are mostly of a bacterial origin and are introduced into the human diet mainly through fermented cheeses. Current knowledge about the kinetics of different forms of vitamin K, their detection, and their toxicity are discussed in this review.
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Mladěnka, P., Macáková, K., Krčmová, L. K., Javorská, L., Mrštná, K., Carazo, A., Protti, M., Remião, F., Nováková, L., & collaborators, T. O. R. A. (2021). Vitamin K – sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity. Nutrition Reviews, 80(4), 677–698. https://doi.org/10.1093/nutrit/nuab061
Mladěnka, Přemysl, et al. "Vitamin K – sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity." Nutrition Reviews, vol. 80, no. 4, 2021, pp. 677–698, https://doi.org/10.1093/nutrit/nuab061.
Mladěnka, Přemysl, Kateřina Macáková, Lenka Kujovská Krčmová, Lenka Javorská, Kristýna Mrštná, Alejandro Carazo, Michele Protti, Fernando Remião, Lucie Nováková, and the OEMONOM researchers and collaborators. "Vitamin K – sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity." Nutrition Reviews 80, no. 4 (2021): 677–698. https://doi.org/10.1093/nutrit/nuab061.
Mladěnka P., Macáková K., Krčmová L. K. [и др.] Vitamin K – sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity // Nutrition Reviews. — 2021. — Vol. 80, № 4. — P. 677–698. — URL: https://doi.org/10.1093/nutrit/nuab061
@article{mladenka2021vitamin,
title = {{Vitamin K – sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity}},
author = {Přemysl Mladěnka and Kateřina Macáková and Lenka Kujovská Krčmová and Lenka Javorská and Kristýna Mrštná and Alejandro Carazo and Michele Protti and Fernando Remião and Lucie Nováková and the OEMONOM researchers and collaborators},
journal = {Nutrition Reviews},
year = {2021},
volume = {80},
number = {4},
pages = {677--698},
doi = {10.1093/nutrit/nuab061},
url = {https://doi.org/10.1093/nutrit/nuab061}
}TY - JOUR AU - Mladěnka, Přemysl AU - Macáková, Kateřina AU - Krčmová, Lenka Kujovská AU - Javorská, Lenka AU - Mrštná, Kristýna AU - Carazo, Alejandro AU - Protti, Michele AU - Remião, Fernando AU - Nováková, Lucie AU - collaborators, the OEMONOM researchers and TI - Vitamin K – sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity JO - Nutrition Reviews VL - 80 IS - 4 SP - 677 EP - 698 PY - 2021 DA - 2021/07/09 DO - 10.1093/nutrit/nuab061 UR - https://doi.org/10.1093/nutrit/nuab061 ER -
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