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Sam Asher, Ruth Stephen, Päivi Mäntylä, Anna Liisa Suominen, Alina Solomon
Background Emerging evidence indicates that poor periodontal health adversely impacts cognition. This review examined the available longitudinal evidence concerning the effect of poor periodontal health on cognitive decline and dementia. Methods Comprehensive literature search was conducted on five electronic databases for relevant studies published until April 2022. Longitudinal studies having periodontal health as exposure and cognitive decline and/or dementia as outcomes were considered. Random effects pooled estimates and 95% confidence intervals were generated (pooled odds ratio for cognitive decline and hazards ratio for dementia) to assess whether poor periodontal health increases the risk of cognitive decline and dementia. Heterogeneity between studies was estimated by I 2 and the quality of available evidence was assessed through quality assessment criteria. Results Adopted search strategy produced 2132 studies for cognitive decline and 2023 for dementia, from which 47 studies (24 for cognitive decline and 23 for dementia) were included in this review. Poor periodontal health (reflected by having periodontitis, tooth loss, deep periodontal pockets, or alveolar bone loss) was associated with both cognitive decline (OR = 1.23; 1.05–1.44) and dementia (HR = 1.21; 1.07–1.38). Further analysis, based on measures of periodontal assessment, found tooth loss to independently increase the risk of both cognitive decline (OR = 1.23; 1.09–1.39) and dementia (HR = 1.13; 1.04–1.23). Stratified analysis based on the extent of tooth loss indicated partial tooth loss to be important for cognitive decline (OR = 1.50; 1.02–2.23) and complete tooth loss for dementia (HR = 1.23; 1.05–1.45). However, the overall quality of evidence was low, and associations were at least partly due to reverse causality. Conclusions Poor periodontal health and tooth loss appear to increase the risk of both cognitive decline and dementia. However, the available evidence is limited (e.g., highly heterogenous, lacking robust methodology) to draw firm conclusions. Further well‐designed studies involving standardized periodontal and cognitive health assessment and addressing reverse causality are highly warranted.
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Asher, S., Stephen, R., Mäntylä, P., Suominen, A. L., & Solomon, A. (2022). Periodontal health, cognitive decline, and dementia: A systematic review and meta‐analysis of longitudinal studies. Journal of the American Geriatrics Society, 70(9), 2695–2709. https://doi.org/10.1111/jgs.17978
Asher, Sam, et al. "Periodontal health, cognitive decline, and dementia: A systematic review and meta‐analysis of longitudinal studies." Journal of the American Geriatrics Society, vol. 70, no. 9, 2022, pp. 2695–2709, https://doi.org/10.1111/jgs.17978.
Asher, Sam, Ruth Stephen, Päivi Mäntylä, Anna Liisa Suominen, and Alina Solomon. "Periodontal health, cognitive decline, and dementia: A systematic review and meta‐analysis of longitudinal studies." Journal of the American Geriatrics Society 70, no. 9 (2022): 2695–2709. https://doi.org/10.1111/jgs.17978.
Asher S., Stephen R., Mäntylä P. [и др.] Periodontal health, cognitive decline, and dementia: A systematic review and meta‐analysis of longitudinal studies // Journal of the American Geriatrics Society. — 2022. — Vol. 70, № 9. — P. 2695–2709. — URL: https://doi.org/10.1111/jgs.17978
@article{asher2022periodontal,
title = {{Periodontal health, cognitive decline, and dementia: A systematic review and meta‐analysis of longitudinal studies}},
author = {Sam Asher and Ruth Stephen and Päivi Mäntylä and Anna Liisa Suominen and Alina Solomon},
journal = {Journal of the American Geriatrics Society},
year = {2022},
volume = {70},
number = {9},
pages = {2695--2709},
doi = {10.1111/jgs.17978},
url = {https://doi.org/10.1111/jgs.17978}
}TY - JOUR AU - Asher, Sam AU - Stephen, Ruth AU - Mäntylä, Päivi AU - Suominen, Anna Liisa AU - Solomon, Alina TI - Periodontal health, cognitive decline, and dementia: A systematic review and meta‐analysis of longitudinal studies JO - Journal of the American Geriatrics Society VL - 70 IS - 9 SP - 2695 EP - 2709 PY - 2022 DA - 2022/09/01 DO - 10.1111/jgs.17978 UR - https://doi.org/10.1111/jgs.17978 ER -
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