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George Hajishengallis
Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause-and-effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis-systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis-linked comorbidities.
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Hajishengallis, G. (2022). Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications. Periodontology 2000, 89(1), 9–18. https://doi.org/10.1111/prd.12430
Hajishengallis, George. "Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications." Periodontology 2000, vol. 89, no. 1, 2022, pp. 9–18, https://doi.org/10.1111/prd.12430.
Hajishengallis, George. "Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications." Periodontology 2000 89, no. 1 (2022): 9–18. https://doi.org/10.1111/prd.12430.
Hajishengallis G. Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications // Periodontology 2000. — 2022. — Vol. 89, № 1. — P. 9–18. — URL: https://doi.org/10.1111/prd.12430
@article{hajishengallis2022interconnection,
title = {{Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications}},
author = {George Hajishengallis},
journal = {Periodontology 2000},
year = {2022},
volume = {89},
number = {1},
pages = {9--18},
doi = {10.1111/prd.12430},
url = {https://doi.org/10.1111/prd.12430}
}TY - JOUR AU - Hajishengallis, George TI - Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications JO - Periodontology 2000 VL - 89 IS - 1 SP - 9 EP - 18 PY - 2022 DA - 2022/03/04 DO - 10.1111/prd.12430 UR - https://doi.org/10.1111/prd.12430 ER -
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