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Fumito Endo, Atsushi Kasai, Joselyn S. Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, Baljit S. Khakh
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, and morphology across the mouse central nervous system (CNS). We identified shared and region-specific astrocytic genes and functions and explored the cellular origins of their regional diversity. We identified gene networks correlated with astrocyte morphology, several of which unexpectedly contained Alzheimer's disease (AD) risk genes. CRISPR/Cas9-mediated reduction of candidate genes reduced astrocyte morphological complexity and resulted in cognitive deficits. The same genes were down-regulated in human AD, in an AD mouse model that displayed reduced astrocyte morphology, and in other human brain disorders. We thus provide comprehensive molecular data on astrocyte diversity and mechanisms across the CNS and on the molecular basis of astrocyte morphology in health and disease.
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Endo, F., Kasai, A., Soto, J. S., Yu, X., Qu, Z., Hashimoto, H., Gradinaru, V., Kawaguchi, R., & Khakh, B. S. (2022). Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science, 378(6619), eadc9020. https://doi.org/10.1126/science.adc9020
Endo, Fumito, et al. "Molecular basis of astrocyte diversity and morphology across the CNS in health and disease." Science, vol. 378, no. 6619, 2022, pp. eadc9020, https://doi.org/10.1126/science.adc9020.
Endo, Fumito, Atsushi Kasai, Joselyn S. Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, and Baljit S. Khakh. "Molecular basis of astrocyte diversity and morphology across the CNS in health and disease." Science 378, no. 6619 (2022): eadc9020. https://doi.org/10.1126/science.adc9020.
Endo F., Kasai A., Soto J. S. [и др.] Molecular basis of astrocyte diversity and morphology across the CNS in health and disease // Science. — 2022. — Vol. 378, № 6619. — P. eadc9020. — URL: https://doi.org/10.1126/science.adc9020
@article{endo2022molecular,
title = {{Molecular basis of astrocyte diversity and morphology across the CNS in health and disease}},
author = {Fumito Endo and Atsushi Kasai and Joselyn S. Soto and Xinzhu Yu and Zhe Qu and Hitoshi Hashimoto and Viviana Gradinaru and Riki Kawaguchi and Baljit S. Khakh},
journal = {Science},
year = {2022},
volume = {378},
number = {6619},
pages = {eadc9020},
doi = {10.1126/science.adc9020},
url = {https://doi.org/10.1126/science.adc9020}
}TY - JOUR AU - Endo, Fumito AU - Kasai, Atsushi AU - Soto, Joselyn S. AU - Yu, Xinzhu AU - Qu, Zhe AU - Hashimoto, Hitoshi AU - Gradinaru, Viviana AU - Kawaguchi, Riki AU - Khakh, Baljit S. TI - Molecular basis of astrocyte diversity and morphology across the CNS in health and disease JO - Science VL - 378 IS - 6619 SP - eadc9020 PY - 2022 DA - 2022/11/03 DO - 10.1126/science.adc9020 UR - https://doi.org/10.1126/science.adc9020 ER -
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