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Ruben Bill, Pratyaksha Wirapati, Marius Messemaker, Whijae Roh, Béatrice Zitti, Florent Duval, Máté Kiss, Jong Chul Park, Talia M. Saal, Jan Hoelzl and 23 more
Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and neck squamous cell carcinomas. We found that macrophage polarity—defined by CXCL9 and SPP1 (CS) expression but not by conventional M1 and M2 markers—had a noticeably strong prognostic association. CS macrophage polarity also identified a highly coordinated network of either pro- or antitumor variables, which involved each tumor-associated cell type and was spatially organized. We extended these findings to other cancer indications. Overall, these results suggest that, despite their complexity, TMEs coordinate coherent responses that control human cancers and for which CS macrophage polarity is a relevant yet simple variable.
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Bill, R., Wirapati, P., Messemaker, M., Roh, W., Zitti, B., Duval, F., Kiss, M., Park, J. C., Saal, T. M., Hoelzl, J., Tarussio, D., Benedetti, F., Tissot, S. R., Kandalaft, L. E., Varrone, M., Ciriello, G., McKee, T., Monnier, Y., Mermod, M., … Pittet, M. J. (2023). CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science, 381(6657), 515–524. https://doi.org/10.1126/science.ade2292
Bill, Ruben, et al. "CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers." Science, vol. 381, no. 6657, 2023, pp. 515–524, https://doi.org/10.1126/science.ade2292.
Bill, Ruben, Pratyaksha Wirapati, Marius Messemaker, Whijae Roh, Béatrice Zitti, Florent Duval, Máté Kiss, et al. "CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers." Science 381, no. 6657 (2023): 515–524. https://doi.org/10.1126/science.ade2292.
Bill R., Wirapati P., Messemaker M. [и др.] CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers // Science. — 2023. — Vol. 381, № 6657. — P. 515–524. — URL: https://doi.org/10.1126/science.ade2292
@article{bill2023cxclspp,
title = {{CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers}},
author = {Ruben Bill and Pratyaksha Wirapati and Marius Messemaker and Whijae Roh and Béatrice Zitti and Florent Duval and Máté Kiss and Jong Chul Park and Talia M. Saal and Jan Hoelzl and David Tarussio and Fabrizio Benedetti and Stéphanie R. Tissot and Lana Elias Kandalaft and Marco Varrone and Giovanni Ciriello and Thomas McKee and Yan Monnier and Maxime Mermod and Emily M. Blaum and Irena Gushterova and Anna L. K. Gonye and Nir Hacohen and Gad A. Getz and Thorsten R. Mempel and Allon Moshe Klein and Ralph Weissleder and William C. Faquin and Peter M. Sadow and Derrick T. Lin and Sara Isabel Pai and Moshe Sade-Feldman and Mikaël J. Pittet},
journal = {Science},
year = {2023},
volume = {381},
number = {6657},
pages = {515--524},
doi = {10.1126/science.ade2292},
url = {https://doi.org/10.1126/science.ade2292}
}TY - JOUR AU - Bill, Ruben AU - Wirapati, Pratyaksha AU - Messemaker, Marius AU - Roh, Whijae AU - Zitti, Béatrice AU - Duval, Florent AU - Kiss, Máté AU - Park, Jong Chul AU - Saal, Talia M. AU - Hoelzl, Jan AU - Tarussio, David AU - Benedetti, Fabrizio AU - Tissot, Stéphanie R. AU - Kandalaft, Lana Elias AU - Varrone, Marco AU - Ciriello, Giovanni AU - McKee, Thomas AU - Monnier, Yan AU - Mermod, Maxime AU - Blaum, Emily M. AU - Gushterova, Irena AU - Gonye, Anna L. K. AU - Hacohen, Nir AU - Getz, Gad A. AU - Mempel, Thorsten R. AU - Klein, Allon Moshe AU - Weissleder, Ralph AU - Faquin, William C. AU - Sadow, Peter M. AU - Lin, Derrick T. AU - Pai, Sara Isabel AU - Sade-Feldman, Moshe AU - Pittet, Mikaël J. TI - CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers JO - Science VL - 381 IS - 6657 SP - 515 EP - 524 PY - 2023 DA - 2023/08/03 DO - 10.1126/science.ade2292 UR - https://doi.org/10.1126/science.ade2292 ER -
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