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Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, Hannah N. Saeger and 4 more
Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics. Activation of 5-hydroxytryptamine (serotonin) 2A receptors (5-HT2ARs) is essential for psychedelic-induced cortical plasticity, but it is currently unclear why some 5-HT2AR agonists promote neuroplasticity, whereas others do not. We used molecular and genetic tools to demonstrate that intracellular 5-HT2ARs mediate the plasticity-promoting properties of psychedelics; these results explain why serotonin does not engage similar plasticity mechanisms. This work emphasizes the role of location bias in 5-HT2AR signaling, identifies intracellular 5-HT2ARs as a therapeutic target, and raises the intriguing possibility that serotonin might not be the endogenous ligand for intracellular 5-HT2ARs in the cortex.
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Vargas, M. V., Dunlap, L. E., Dong, C., Carter, S. J., Tombari, R. J., Jami, S. A., Cameron, L. P., Patel, S. D., Hennessey, J. J., Saeger, H. N., McCorvy, J. D., Gray, J. A., Tian, L., & Olson, D. E. (2023). Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science, 379(6633), 700–706. https://doi.org/10.1126/science.adf0435
Vargas, Maxemiliano V., et al. "Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors." Science, vol. 379, no. 6633, 2023, pp. 700–706, https://doi.org/10.1126/science.adf0435.
Vargas, Maxemiliano V., Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, et al. "Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors." Science 379, no. 6633 (2023): 700–706. https://doi.org/10.1126/science.adf0435.
Vargas M. V., Dunlap L. E., Dong C. [и др.] Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors // Science. — 2023. — Vol. 379, № 6633. — P. 700–706. — URL: https://doi.org/10.1126/science.adf0435
@article{vargas2023psychedelics,
title = {{Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors}},
author = {Maxemiliano V. Vargas and Lee E. Dunlap and Chunyang Dong and Samuel J. Carter and Robert J. Tombari and Shekib A. Jami and Lindsay P. Cameron and Seona D. Patel and Joseph J. Hennessey and Hannah N. Saeger and John D. McCorvy and John A. Gray and Lin Tian and David E. Olson},
journal = {Science},
year = {2023},
volume = {379},
number = {6633},
pages = {700--706},
doi = {10.1126/science.adf0435},
url = {https://doi.org/10.1126/science.adf0435}
}TY - JOUR AU - Vargas, Maxemiliano V. AU - Dunlap, Lee E. AU - Dong, Chunyang AU - Carter, Samuel J. AU - Tombari, Robert J. AU - Jami, Shekib A. AU - Cameron, Lindsay P. AU - Patel, Seona D. AU - Hennessey, Joseph J. AU - Saeger, Hannah N. AU - McCorvy, John D. AU - Gray, John A. AU - Tian, Lin AU - Olson, David E. TI - Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors JO - Science VL - 379 IS - 6633 SP - 700 EP - 706 PY - 2023 DA - 2023/02/16 DO - 10.1126/science.adf0435 UR - https://doi.org/10.1126/science.adf0435 ER -
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