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Hongyue Zhang, Ze‐sheng Li, Changyong Gao, Xinjian Fan, Yuxin Pang, Tianlong Li, Zhiguang Wu, Hui Xie, Qiang Zhi He
membrane camouflaging enhances the efficiency of phagocytosis and also prevents drug leakage inside the neutrophils. With controllable intravascular movement upon exposure to a rotating magnetic field, the neutrobots could autonomously aggregate in the brain and subsequently cross the blood-brain barrier through the positive chemotactic motion of neutrobots along the gradient of inflammatory factors. The use of such dual-responsive neutrobots for targeted drug delivery substantially inhibits the proliferation of tumor cells compared with traditional drug injection. Inheriting the biological characteristics and functions of natural neutrophils that current artificial microrobots cannot match, the neutrobots developed in this study provide a promising pathway to precision biomedicine in the future.
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Zhang, H., Li, Z., Gao, C., Fan, X., Pang, Y., Li, T., Wu, Z., Xie, H., & He, Q. Z. (2021). Dual-responsive biohybrid neutrobots for active target delivery. Science Robotics, 6(52). https://doi.org/10.1126/scirobotics.aaz9519
Zhang, Hongyue, et al. "Dual-responsive biohybrid neutrobots for active target delivery." Science Robotics, vol. 6, no. 52, 2021, https://doi.org/10.1126/scirobotics.aaz9519.
Zhang, Hongyue, Ze‐sheng Li, Changyong Gao, Xinjian Fan, Yuxin Pang, Tianlong Li, Zhiguang Wu, Hui Xie, and Qiang Zhi He. "Dual-responsive biohybrid neutrobots for active target delivery." Science Robotics 6, no. 52 (2021). https://doi.org/10.1126/scirobotics.aaz9519.
Zhang H., Li Z., Gao C. [и др.] Dual-responsive biohybrid neutrobots for active target delivery // Science Robotics. — 2021. — Vol. 6, № 52. — URL: https://doi.org/10.1126/scirobotics.aaz9519
@article{zhang2021dualresponsive,
title = {{Dual-responsive biohybrid neutrobots for active target delivery}},
author = {Hongyue Zhang and Ze‐sheng Li and Changyong Gao and Xinjian Fan and Yuxin Pang and Tianlong Li and Zhiguang Wu and Hui Xie and Qiang Zhi He},
journal = {Science Robotics},
year = {2021},
volume = {6},
number = {52},
doi = {10.1126/scirobotics.aaz9519},
url = {https://doi.org/10.1126/scirobotics.aaz9519}
}TY - JOUR AU - Zhang, Hongyue AU - Li, Ze‐sheng AU - Gao, Changyong AU - Fan, Xinjian AU - Pang, Yuxin AU - Li, Tianlong AU - Wu, Zhiguang AU - Xie, Hui AU - He, Qiang Zhi TI - Dual-responsive biohybrid neutrobots for active target delivery JO - Science Robotics VL - 6 IS - 52 PY - 2021 DA - 2021/03/17 DO - 10.1126/scirobotics.aaz9519 UR - https://doi.org/10.1126/scirobotics.aaz9519 ER -
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