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Guilherme Dias de Melo, Françoise Lazarini, Sylvain Levallois, Charlotte Hautefort, Vincent Michel, Florence Larrous, Benjamin Vérillaud, Caroline Aparicio, Sébastien Wagner, Gilles Gheusi and 11 more
Whereas recent investigations have revealed viral, inflammatory, and vascular factors involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung pathogenesis, the pathophysiology of neurological disorders in coronavirus disease 2019 (COVID-19) remains poorly understood. Olfactory and taste dysfunction are common in COVID-19, especially in mildly symptomatic patients. Here, we conducted a virologic, molecular, and cellular study of the olfactory neuroepithelium of seven patients with COVID-19 presenting with acute loss of smell. We report evidence that the olfactory neuroepithelium is a major site of SARS-CoV2 infection with multiple cell types, including olfactory sensory neurons, support cells, and immune cells, becoming infected. SARS-CoV-2 replication in the olfactory neuroepithelium was associated with local inflammation. Furthermore, we showed that SARS-CoV-2 induced acute anosmia and ageusia in golden Syrian hamsters, lasting as long as the virus remained in the olfactory epithelium and the olfactory bulb. Last, olfactory mucosa sampling from patients showing long-term persistence of COVID-19-associated anosmia revealed the presence of virus transcripts and of SARS-CoV-2-infected cells, together with protracted inflammation. SARS-CoV-2 persistence and associated inflammation in the olfactory neuroepithelium may account for prolonged or relapsing symptoms of COVID-19, such as loss of smell, which should be considered for optimal medical management of this disease.
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Melo, G. D. D., Lazarini, F., Levallois, S., Hautefort, C., Michel, V., Larrous, F., Vérillaud, B., Aparicio, C., Wagner, S., Gheusi, G., Kergoat, L., Kornobis, É., Donati, F., Cokelaer, T., Hervochon, R., Madec, Y., Roze, E. F., Salmon, D., Bourhy, H., … Lledo, P. (2021). COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Science Translational Medicine, 13(596). https://doi.org/10.1126/scitranslmed.abf8396
Melo, Guilherme Dias de, et al. "COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters." Science Translational Medicine, vol. 13, no. 596, 2021, https://doi.org/10.1126/scitranslmed.abf8396.
Melo, Guilherme Dias de, Françoise Lazarini, Sylvain Levallois, Charlotte Hautefort, Vincent Michel, Florence Larrous, Benjamin Vérillaud, et al. "COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters." Science Translational Medicine 13, no. 596 (2021). https://doi.org/10.1126/scitranslmed.abf8396.
Melo G. D. D., Lazarini F., Levallois S. [и др.] COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters // Science Translational Medicine. — 2021. — Vol. 13, № 596. — URL: https://doi.org/10.1126/scitranslmed.abf8396
@article{melo2021covidrelated,
title = {{COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters}},
author = {Guilherme Dias de Melo and Françoise Lazarini and Sylvain Levallois and Charlotte Hautefort and Vincent Michel and Florence Larrous and Benjamin Vérillaud and Caroline Aparicio and Sébastien Wagner and Gilles Gheusi and Lauriane Kergoat and Étienne Kornobis and Flora Donati and Thomas Cokelaer and Rémi Hervochon and Yoann Madec and Emmanuel Flamand Roze and Dominique Salmon and Hervé Bourhy and Marc Lecuit and Pierre‐Marie Lledo},
journal = {Science Translational Medicine},
year = {2021},
volume = {13},
number = {596},
doi = {10.1126/scitranslmed.abf8396},
url = {https://doi.org/10.1126/scitranslmed.abf8396}
}TY - JOUR AU - Melo, Guilherme Dias de AU - Lazarini, Françoise AU - Levallois, Sylvain AU - Hautefort, Charlotte AU - Michel, Vincent AU - Larrous, Florence AU - Vérillaud, Benjamin AU - Aparicio, Caroline AU - Wagner, Sébastien AU - Gheusi, Gilles AU - Kergoat, Lauriane AU - Kornobis, Étienne AU - Donati, Flora AU - Cokelaer, Thomas AU - Hervochon, Rémi AU - Madec, Yoann AU - Roze, Emmanuel Flamand AU - Salmon, Dominique AU - Bourhy, Hervé AU - Lecuit, Marc AU - Lledo, Pierre‐Marie TI - COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters JO - Science Translational Medicine VL - 13 IS - 596 PY - 2021 DA - 2021/05/03 DO - 10.1126/scitranslmed.abf8396 UR - https://doi.org/10.1126/scitranslmed.abf8396 ER -
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