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Gabriel D. Victora, Michel C. Nussenzweig
Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification and affinity-driven selection of immunoglobulins that produces the high-affinity antibodies essential for effective humoral immunity. Here, we review recent developments in the field of GC biology, primarily as it pertains to GCs induced by infection or immunization. First, we summarize the phenotype and function of the different cell types that compose the GC, focusing on GC B cells. Then, we review the cellular and molecular bases of affinity-dependent selection within the GC and the export of memory and plasma cells. Finally, we present an overview of the emerging field of GC clonal dynamics, focusing on how GC and post-GC selection shapes the diversity of antibodies secreted into serum.
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Victora, G. D., & Nussenzweig, M. C. (2022). Germinal Centers. Annual Review of Immunology, 40(1), 413–442. https://doi.org/10.1146/annurev-immunol-120419-022408
Victora, Gabriel D., and Michel C. Nussenzweig. "Germinal Centers." Annual Review of Immunology, vol. 40, no. 1, 2022, pp. 413–442, https://doi.org/10.1146/annurev-immunol-120419-022408.
Victora, Gabriel D., and Michel C. Nussenzweig. "Germinal Centers." Annual Review of Immunology 40, no. 1 (2022): 413–442. https://doi.org/10.1146/annurev-immunol-120419-022408.
Victora G. D., Nussenzweig M. C. Germinal Centers // Annual Review of Immunology. — 2022. — Vol. 40, № 1. — P. 413–442. — URL: https://doi.org/10.1146/annurev-immunol-120419-022408
@article{victora2022germinal,
title = {{Germinal Centers}},
author = {Gabriel D. Victora and Michel C. Nussenzweig},
journal = {Annual Review of Immunology},
year = {2022},
volume = {40},
number = {1},
pages = {413--442},
doi = {10.1146/annurev-immunol-120419-022408},
url = {https://doi.org/10.1146/annurev-immunol-120419-022408}
}TY - JOUR AU - Victora, Gabriel D. AU - Nussenzweig, Michel C. TI - Germinal Centers JO - Annual Review of Immunology VL - 40 IS - 1 SP - 413 EP - 442 PY - 2022 DA - 2022/02/03 DO - 10.1146/annurev-immunol-120419-022408 UR - https://doi.org/10.1146/annurev-immunol-120419-022408 ER -
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