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Xi Wang, Yiqun Jia, Liling Wen, Wenxin Mu, Xianrui Wu, Tao Liu, Xiangqi Liu, Juan Fang, Yizhao Luan, Ping Chen and 8 more
Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with various digestive cancers. However, whether P. gingivalis can promote colorectal cancer and the underlying mechanism associated with such promotion remains unclear. In this study, we found that P. gingivalis was enriched in human feces and tissue samples from patients with colorectal cancer compared with those from patients with colorectal adenoma or healthy subjects. Cohort studies demonstrated that P. gingivalis infection was associated with poor prognosis in colorectal cancer. P. gingivalis increased tumor counts and tumor volume in the ApcMin/+ mouse model and increased tumor growth in orthotopic rectal and subcutaneous carcinoma models. Furthermore, orthotopic tumors from mice exposed to P. gingivalis exhibited tumor-infiltrating myeloid cell recruitment and a proinflammatory signature. P. gingivalis promoted colorectal cancer via NLRP3 inflammasome activation in vitro and in vivo. NLRP3 chimeric mice harboring orthotopic tumors showed that the effect of NLRP3 on P. gingivalis pathogenesis was mediated by hematopoietic sources. Collectively, these data suggest that P. gingivalis contributes to colorectal cancer neoplasia progression by activating the hematopoietic NLRP3 inflammasome. Significance: This study demonstrates that the periodontal pathogen P. gingivalis can promote colorectal tumorigenesis by recruiting myeloid cells and creating a proinflammatory tumor microenvironment.
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Wang, X., Jia, Y., Wen, L., Mu, W., Wu, X., Liu, T., Liu, X., Fang, J., Luan, Y., Chen, P., Gao, J., Nguyen, K.-A. T., Cui, J., Zeng, G., Lan, P., Chen, Q., Cheng, B., & Wang, Z. (2021). Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome. Cancer Research, 81(10), 2745–2759. https://doi.org/10.1158/0008-5472.can-20-3827
Wang, Xi, et al. "Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome." Cancer Research, vol. 81, no. 10, 2021, pp. 2745–2759, https://doi.org/10.1158/0008-5472.can-20-3827.
Wang, Xi, Yiqun Jia, Liling Wen, Wenxin Mu, Xianrui Wu, Tao Liu, Xiangqi Liu, et al. "Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome." Cancer Research 81, no. 10 (2021): 2745–2759. https://doi.org/10.1158/0008-5472.can-20-3827.
Wang X., Jia Y., Wen L. [и др.] Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome // Cancer Research. — 2021. — Vol. 81, № 10. — P. 2745–2759. — URL: https://doi.org/10.1158/0008-5472.can-20-3827
@article{wang2021porphyromonas,
title = {{Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome}},
author = {Xi Wang and Yiqun Jia and Liling Wen and Wenxin Mu and Xianrui Wu and Tao Liu and Xiangqi Liu and Juan Fang and Yizhao Luan and Ping Chen and Jinlong Gao and Ky-Anh T. Nguyen and Jun Cui and Gucheng Zeng and Ping Lan and Qianming Chen and Bin Cheng and Zhi Wang},
journal = {Cancer Research},
year = {2021},
volume = {81},
number = {10},
pages = {2745--2759},
doi = {10.1158/0008-5472.can-20-3827},
url = {https://doi.org/10.1158/0008-5472.can-20-3827}
}TY - JOUR AU - Wang, Xi AU - Jia, Yiqun AU - Wen, Liling AU - Mu, Wenxin AU - Wu, Xianrui AU - Liu, Tao AU - Liu, Xiangqi AU - Fang, Juan AU - Luan, Yizhao AU - Chen, Ping AU - Gao, Jinlong AU - Nguyen, Ky-Anh T. AU - Cui, Jun AU - Zeng, Gucheng AU - Lan, Ping AU - Chen, Qianming AU - Cheng, Bin AU - Wang, Zhi TI - Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome JO - Cancer Research VL - 81 IS - 10 SP - 2745 EP - 2759 PY - 2021 DA - 2021/03/18 DO - 10.1158/0008-5472.can-20-3827 UR - https://doi.org/10.1158/0008-5472.can-20-3827 ER -
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