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Yingcheng Wu, Shuaixi Yang, Jiaqiang Ma, Zechuan Chen, Guohe Song, Dongning Rao, Yifei Cheng, Siyuan Huang, Yifei Liu, Shan Jiang and 11 more
Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 matched samples by using single-cell RNA sequencing and spatial transcriptomics. Strikingly, the metastatic microenvironment underwent remarkable spatial reprogramming of immunosuppressive cells such as MRC1+ CCL18+ M2-like macrophages. We further developed scMetabolism, a computational pipeline for quantifying single-cell metabolism, and observed that those macrophages harbored enhanced metabolic activity. Interestingly, neoadjuvant chemotherapy could block this status and restore the antitumor immune balance in responsive patients, whereas the nonresponsive patients deteriorated into a more suppressive one. Our work described the immune evolution of metastasis and uncovered the black box of how tumors respond to neoadjuvant chemotherapy. Significance: We present a single-cell and spatial atlas of colorectal liver metastasis and found the highly metabolically activated MRC1+ CCL18+ M2-like macrophages in metastatic sites. Efficient neoadjuvant chemotherapy can slow down such metabolic activation, raising the possibility to target metabolism pathways in metastasis. This article is highlighted in the In This Issue feature, p. 1
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Wu, Y., Yang, S., Ma, J., Chen, Z., Song, G., Rao, D., Cheng, Y., Huang, S., Liu, Y., Jiang, S., Liu, J., Huang, X., Wang, X., Qiu, S., Xu, J., Xi, R., Bai, F., Zhou, J., Fan, J., … Gao, Q. (2021). Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. Cancer Discovery, 12(1), 134–153. https://doi.org/10.1158/2159-8290.cd-21-0316
Wu, Yingcheng, et al. "Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level." Cancer Discovery, vol. 12, no. 1, 2021, pp. 134–153, https://doi.org/10.1158/2159-8290.cd-21-0316.
Wu, Yingcheng, Shuaixi Yang, Jiaqiang Ma, Zechuan Chen, Guohe Song, Dongning Rao, Yifei Cheng, et al. "Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level." Cancer Discovery 12, no. 1 (2021): 134–153. https://doi.org/10.1158/2159-8290.cd-21-0316.
Wu Y., Yang S., Ma J. [и др.] Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level // Cancer Discovery. — 2021. — Vol. 12, № 1. — P. 134–153. — URL: https://doi.org/10.1158/2159-8290.cd-21-0316
@article{wu2021spatiotemporal,
title = {{Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level}},
author = {Yingcheng Wu and Shuaixi Yang and Jiaqiang Ma and Zechuan Chen and Guohe Song and Dongning Rao and Yifei Cheng and Siyuan Huang and Yifei Liu and Shan Jiang and Jinxia Liu and Xiaowu Huang and Xiaoying Wang and Shuangjian Qiu and Jianmin Xu and Ruibin Xi and Fan Bai and Jian Zhou and Jia Fan and Xiaoming Zhang and Qiang Gao},
journal = {Cancer Discovery},
year = {2021},
volume = {12},
number = {1},
pages = {134--153},
doi = {10.1158/2159-8290.cd-21-0316},
url = {https://doi.org/10.1158/2159-8290.cd-21-0316}
}TY - JOUR AU - Wu, Yingcheng AU - Yang, Shuaixi AU - Ma, Jiaqiang AU - Chen, Zechuan AU - Song, Guohe AU - Rao, Dongning AU - Cheng, Yifei AU - Huang, Siyuan AU - Liu, Yifei AU - Jiang, Shan AU - Liu, Jinxia AU - Huang, Xiaowu AU - Wang, Xiaoying AU - Qiu, Shuangjian AU - Xu, Jianmin AU - Xi, Ruibin AU - Bai, Fan AU - Zhou, Jian AU - Fan, Jia AU - Zhang, Xiaoming AU - Gao, Qiang TI - Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level JO - Cancer Discovery VL - 12 IS - 1 SP - 134 EP - 153 PY - 2021 DA - 2021/08/20 DO - 10.1158/2159-8290.cd-21-0316 UR - https://doi.org/10.1158/2159-8290.cd-21-0316 ER -
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