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Anna B. Fishbein, Kristen L. Knutson, Phyllis C. Zee
Biomarkers of circadian rhythm and circadian disruptionAlthough the SCN rhythm cannot be directly measured in humans, the timing of melatonin onset and amplitude measured in plasma or saliva, or the melatonin metabolite 6-sulfatoxymelatonin in urine, are gold standard biomarkers of circadian rhythms.The collection of 24-hour urine samples is particularly useful to assess circadian amplitude of melatonin in special populations, such as pediatric patients in whom blood or salivary samples might be difficult to obtain (8), and has been shown to be a useful treatment-responsive biomarker of circadian disruption in neurologic diseases, such as Alzheimer's disease (AD) (9) and pediatric epilepsy (10).Although less direct, other commonly used measures include rest/ activity cycles derived from actigraphy, and other hormonal, metabolic, and cardiovascular rhythms (7).Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes at individual and population levels.Evidence points to a bidirectional relationship, in that circadian disruption increases disease severity and many diseases can disrupt circadian rhythms.Importantly, circadian disruption can increase the risk for the expression and development of neurologic, psychiatric, cardiometabolic, and immune disorders.Thus, harnessing the rich findings from preclinical and translational research in circadian biology to enhance health via circadian-based approaches represents a unique opportunity for personalized/precision medicine and overall societal well-being.In this Review, we discuss the implications of circadian disruption for human health using a bench-to-bedside approach.Evidence from preclinical and translational science is applied to a clinical and population-based approach.Given the broad implications of circadian regulation for human health, this Review focuses its discussion on selected examples in neurologic, psychiatric, metabolic, cardiovascular, allergic, and immunologic disorders that highlight the interrelatedness between circadian disruption and human disease and the potential of circadian-based interventions, such as bright light therapy and exogenous melatonin, as well as chronotherapy to improve and/or modify disease outcomes.
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Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021). Circadian disruption and human health. Journal of Clinical Investigation, 131(19). https://doi.org/10.1172/jci148286
Fishbein, Anna B., et al. "Circadian disruption and human health." Journal of Clinical Investigation, vol. 131, no. 19, 2021, https://doi.org/10.1172/jci148286.
Fishbein, Anna B., Kristen L. Knutson, and Phyllis C. Zee. "Circadian disruption and human health." Journal of Clinical Investigation 131, no. 19 (2021). https://doi.org/10.1172/jci148286.
Fishbein A. B., Knutson K. L., Zee P. C. Circadian disruption and human health // Journal of Clinical Investigation. — 2021. — Vol. 131, № 19. — URL: https://doi.org/10.1172/jci148286
@article{fishbein2021circadian,
title = {{Circadian disruption and human health}},
author = {Anna B. Fishbein and Kristen L. Knutson and Phyllis C. Zee},
journal = {Journal of Clinical Investigation},
year = {2021},
volume = {131},
number = {19},
doi = {10.1172/jci148286},
url = {https://doi.org/10.1172/jci148286}
}TY - JOUR AU - Fishbein, Anna B. AU - Knutson, Kristen L. AU - Zee, Phyllis C. TI - Circadian disruption and human health JO - Journal of Clinical Investigation VL - 131 IS - 19 PY - 2021 DA - 2021/09/30 DO - 10.1172/jci148286 UR - https://doi.org/10.1172/jci148286 ER -
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